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Gastric cancer represents one of the most frequent and lethal tumors worldwide today, finding itself in the fifth place in incidence and the third in mortality. Surgery remains the only curative treatment for localized tumors, but only 20% of patients are suitable for surgery due to the lack of specific symptoms and the late diagnosis, especially in Western countries. Additionally, even in patients who receive curative treatment, rates of locoregional relapse and distant metastasis remain high. Palliative chemotherapy is the principal treatment in cases of metastatic disease even if the prognosis of patients receiving chemotherapy is still poor. Therefore, a multidisciplinary evaluation is important in order to improve the efficacy of active treatments. In this context, there is an unmet need for a better understanding of genetic alterations and prognostic and predictive factors in order to choose the best tailored therapy for each patient. The aim of this Special Issue is to focus on the results and problems of multimodality treatment in metastatic gastric cancer, the search for prognostic and predictive factors, and the evaluation of novel strategies for individualized treatment. We are inviting relevant original research, systematic reviews, meta-analyses, and short communications covering the above-mentioned topics.

Medicine --- advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial-mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring --- advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial-mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring

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Tumor markers --- Diagnostic use. --- Molecular diagnosis --- Neoplastic Cells, Circulating. --- Liquid Biopsy. --- Cytodiagnosis. --- Cytodiagnoses --- Cytological Techniques --- Liquid Biopsies --- Biopsies, Liquid --- Biopsy, Liquid --- Cell-Free Nucleic Acids --- Blood Specimen Collection --- Cells, Neoplasm Circulating --- Circulating Cells, Neoplasm --- Circulating Tumor Cells --- Circulating Neoplastic Cells --- Embolic Tumor Cells --- Embolism, Tumor --- Neoplasm Circulating Cells --- Tumor Cells, Embolic --- Cell, Circulating Neoplastic --- Cell, Circulating Tumor --- Cell, Embolic Tumor --- Cell, Neoplasm Circulating --- Cells, Circulating Neoplastic --- Cells, Circulating Tumor --- Cells, Embolic Tumor --- Circulating Neoplastic Cell --- Circulating Tumor Cell --- Embolic Tumor Cell --- Embolisms, Tumor --- Neoplasm Circulating Cell --- Neoplastic Cell, Circulating --- Tumor Cell, Circulating --- Tumor Cell, Embolic --- Tumor Cells, Circulating --- Tumor Embolism --- Tumor Embolisms --- Biòpsia --- Citodiagnòstic. --- Cèl·lules canceroses --- Citologia clínica --- Diagnòstic cel·lular --- Diagnòstic citològic --- Diagnòstic citopatòlogic --- Diagnòstic citoquímic --- Diagnòstic histocitològic --- Diagnostic històlogic --- Diagnòstic de laboratori --- Biòpsia per aspiració --- Histopatologia --- Patologia cel·lular --- Cirurgia operatòria --- Cèl·lules --- Metàstasi --- Càncer

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This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Cancer research. --- Molecular biology. --- Biomedical engineering. --- Stem cells. --- Cancer Research. --- Molecular Medicine. --- Biomedical Engineering/Biotechnology. --- Stem Cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Cancer research --- Breast --- Breast Neoplasms. --- Neoplasm Metastasis. --- Neoplastic Cells, Circulating. --- Cancer --- Molecular aspects. --- Cells, Neoplasm Circulating --- Circulating Cells, Neoplasm --- Circulating Tumor Cells --- Circulating Neoplastic Cells --- Embolic Tumor Cells --- Embolism, Tumor --- Neoplasm Circulating Cells --- Tumor Cells, Embolic --- Cell, Circulating Neoplastic --- Cell, Circulating Tumor --- Cell, Embolic Tumor --- Cell, Neoplasm Circulating --- Cells, Circulating Neoplastic --- Cells, Circulating Tumor --- Cells, Embolic Tumor --- Circulating Neoplastic Cell --- Circulating Tumor Cell --- Embolic Tumor Cell --- Embolisms, Tumor --- Neoplasm Circulating Cell --- Neoplastic Cell, Circulating --- Tumor Cell, Circulating --- Tumor Cell, Embolic --- Tumor Cells, Circulating --- Tumor Embolism --- Tumor Embolisms --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastasis --- Metastases --- Neoplasms --- Breast Carcinoma --- Cancer of the Breast --- Human Mammary Carcinoma --- Malignant Neoplasm of Breast --- Malignant Tumor of Breast --- Mammary Cancer --- Mammary Carcinoma, Human --- Mammary Neoplasm, Human --- Mammary Neoplasms, Human --- Neoplasms, Breast --- Tumors, Breast --- Breast Cancer --- Breast Tumors --- Cancer of Breast --- Breast Carcinomas --- Breast Malignant Neoplasm --- Breast Malignant Neoplasms --- Breast Malignant Tumor --- Breast Malignant Tumors --- Breast Neoplasm --- Breast Tumor --- Cancer, Breast --- Cancer, Mammary --- Cancers, Mammary --- Carcinoma, Breast --- Carcinoma, Human Mammary --- Carcinomas, Breast --- Carcinomas, Human Mammary --- Human Mammary Carcinomas --- Human Mammary Neoplasm --- Human Mammary Neoplasms --- Mammary Cancers --- Mammary Carcinomas, Human --- Neoplasm, Breast --- Neoplasm, Human Mammary --- Neoplasms, Human Mammary --- Tumor, Breast --- Breast Cancer Lymphedema --- secondary --- Càncer de mama --- Cèl·lules canceroses --- Monitoratge de pacients --- Monitoratge fisiològic --- Supervisió electrònica dels malalts --- Supervisió electrònica dels pacients --- Diagnòstic --- Medicina intensiva --- Monitoratge fetal --- Cèl·lules --- Patologia cel·lular --- Metàstasi --- Càncer --- Càncer de pit --- Malalties de la mama --- Càncer ginecològic