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Carprofen inhibits certain pro-inflammatory genes and stimulates the in vitro 
production of glycosaminoglycans. However, it has chondrotoxicity that depends on 
its intra-articular concentration. Hyaluronic acid increases intra-articular viscosity and 
has anti-inflammatory and immunomodulatory effects. It preserves arthritic 
chondrocytes without affecting healthy ones.
Intra-articular injection of hyaluronic acid is more effective at reducing pain and 
lameness than carprofen, although guidelines on viscosupplementation are unclear. 
Nonetheless, carprofen remains preferred for treating osteoarthritis due to its rare 
side effects and analgesic efficacy. The administration of intra-articular hyaluronic 
acid requires anesthesia for each injection and is not commercially available for dogs 
in Belgium, although the therapeutic cascade can be applied.
In conclusion, while both treatments alleviate osteoarthritis pain, it is important to 
consider their respective advantages and disadvantages.

Carprofen --- osteoarthritis --- pharmacodynamic --- analgesic --- cartilage --- chondrocyte --- chondrotoxicity --- mechanism --- pain --- lameness --- hyaluronic --- acid --- carprofène --- arthrose --- pharmacodynamie --- analgésie --- cartilage --- chondrocyte --- chondrotoxicité --- mécanisme --- douleur --- boiterie --- hyaluronique --- acide --- Sciences du vivant > Médecine vétérinaire & santé animale