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Fruits --- Fruits --- Vegetables --- Vegetables --- Keeping quality --- Keeping quality --- Gas packaging --- Gas packaging --- carbon dioxide --- carbon dioxide --- Oxygen --- Oxygen --- Biodegradation. --- Biodegradation --- Models --- Models --- Pseudomonas fluorescens --- Pseudomonas fluorescens --- Listeria --- Listeria --- Enzyme activity --- Enzyme activity --- Enzyme inhibitors --- Enzyme inhibitors --- Chlorogenic acid --- Chlorogenic acid --- Listeria innocua --- Listeria innocua

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Phytochemicals from natural products are now widely used as food additives (antioxidants, pigments), food supplements, cosmetic ingredients, etc. Currently, the majority of the extraction processes implemented on an industrial scale for the production of bioactive-enriched extracts are based on solvents of petroleum origin. However, contemporary trends in green extraction techniques dictate a minimization of solvent use, low-energy processes and novel eco-friendly materials that are environmentally benign. The search for liquids and/or extraction technologies that could meet such requirements is, therefore, an intriguing concept. This book addresses the concept of recovering natural bioactive substances from plant resources, using state-of-the-art extraction technologies, with prospects in the food, cosmetic and pharmaceutical industries.

Research & information: general --- cosmeceutical product --- long-lived trees --- simplex-centroid mixture design --- deep eutectic solvents --- bioactivity --- flavonoids --- extraction --- deep eutectic solvents (DES) --- natural deep eutectic solvents (NaDES) --- Moringa oleifera --- polyphenols --- ultrasonication pretreatment --- antioxidants --- hydroxypropyl β-cyclodextrin --- potato peels --- grape seed --- grape skin --- green extraction --- antioxidant activity --- chlorogenic acid --- caffeine --- β-cyclodextrin --- coffee pulp --- sensory analysis --- cold brew --- n/a

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Nutritional deficiencies, and different nutritional and dietary lifestyles, whether poor or absent of essential nutrients, aside from excess intake, can lead to inflammatory complications and loss of function. Bioactive compounds are non-nutritional components derived from plants, foods, and beverages with a multitude of biological effects. The improvement of analytical techniques has allowed scientific community to state that the regular consumption of bioactive phytochemicals is related to the prevention of numerous pathologies, through mechanisms that involve oxidative stress reduction, gene expression modulation, and even enzymatic activation inhibition.

quercetin --- nervous system --- molecular signals --- pharmacological potential --- cognitive impairment. --- micronuclei --- radioprotectors --- radiation effects --- melanoma --- PNT2 --- B16F10 cells --- Ulmus parvifolia --- wound healing --- matrix metalloproteinase --- transforming growth factor --- skin rejuvenation --- kaempferol --- naringin --- orientin --- rutin --- vitexin --- chlorogenic acid --- citric acid --- malic acid --- quinic acid --- rosmarinic acid --- curcumin --- nanocurcumin --- neurological disorders --- nanocarriers --- liposomes --- cancer --- diet --- flavonoids --- food supplements --- hormesis --- phytoestrogens --- sulforaphane --- resveratrol --- cardiovascular disease --- nanomedicine --- liposome --- nanoformulation --- RNA-dependent RNA polymerase --- remdesivir --- chloroquine --- SARS-CoV-2 --- COVID-19 --- spike glycoproteins --- Acorus calamus --- ethnomedicinal --- phytochemistry --- toxicity --- pharmacological action --- clinical trial --- neuroprotective --- neurological --- metabolic application --- kurarinone --- coronavirus --- HCoV-OC43 --- autophagy --- infection --- MRC-5 cell --- LC3 --- p62/SQSTM1 protein --- n/a

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Metal ions are fundamental elements for the maintenance of the lifespan of plants, animals and humans. Their substantial role in biological systems was recognized a long time ago. They are essential for the maintenance of life and their absence can cause growth disorders, severe malfunction, carcinogenesis or death. They are protagonists as macro- or microelements in several structural and functional roles, participating in many bio-chemical reactions, and arise in several forms. They participate in intra- and intercellular communications, in maintaining electrical charges and osmotic pressure, in photosynthesis and electron transfer processes, in the maintenance of pairing, stacking and the stability of nucleotide bases and also in the regulation of DNA transcription. They contribute to the proper functioning of nerve cells, muscle cells, the brain and the heart, the transport of oxygen and to many other biological processes up to the point that we cannot even imagine a life without metals. In this book, the papers published in the Special Issue “The Role of Metal Ions in Biology, Biochemistry and Medicine” are summarized, providing a picture of metal ion uses in biology, biochemistry and medicine, but also pointing out the toxicity impacts on plants, animals, humans and the environment.

Research & information: general --- aluminium --- chlorophyll fluorescence --- durum wheat --- excitation pressure --- non-photochemical quenching --- photosynthesis --- photoprotection --- photoinhibition --- reactive oxygen species --- triticale --- Cd toxicity --- detoxification mechanism --- photochemical quenching --- photosynthetic heterogeneity --- photoprotective mechanism --- phytoremediation --- plastoquinone pool --- redox state --- spatiotemporal variation --- mercury --- biosorption --- dead cells --- Lysinibacillus sphaericus --- dithizone --- GF-AAS --- EDS-SEM --- adaptive response --- hormetic response --- hydrogen peroxide --- marine angiosperms --- reactive oxygen species (ROS) --- zinc oxide nanoparticles --- titanium dioxide --- nanoparticles --- solubility --- toxicity --- skin --- safety --- bimetallic nanoparticles --- mature leaves --- spatiotemporal heterogeneity --- young leaves --- osteoblasts --- corrosion --- ions --- particles --- osteolysis --- inflammation --- bioimaging --- clary sage --- effective quantum yield (ΦPSΙΙ) --- non-photochemical quenching (NPQ) --- photochemical quenching (qp) --- singlet oxygen (1O2) --- aseptic loosening --- metal ions --- monocytes --- macrophages --- 5-caffeoylquinic acid --- chlorogenic acid --- zinc --- plant phenolic compounds --- oxidative stress --- aluminium --- chlorophyll fluorescence --- durum wheat --- excitation pressure --- non-photochemical quenching --- photosynthesis --- photoprotection --- photoinhibition --- reactive oxygen species --- triticale --- Cd toxicity --- detoxification mechanism --- photochemical quenching --- photosynthetic heterogeneity --- photoprotective mechanism --- phytoremediation --- plastoquinone pool --- redox state --- spatiotemporal variation --- mercury --- biosorption --- dead cells --- Lysinibacillus sphaericus --- dithizone --- GF-AAS --- EDS-SEM --- adaptive response --- hormetic response --- hydrogen peroxide --- marine angiosperms --- reactive oxygen species (ROS) --- zinc oxide nanoparticles --- titanium dioxide --- nanoparticles --- solubility --- toxicity --- skin --- safety --- bimetallic nanoparticles --- mature leaves --- spatiotemporal heterogeneity --- young leaves --- osteoblasts --- corrosion --- ions --- particles --- osteolysis --- inflammation --- bioimaging --- clary sage --- effective quantum yield (ΦPSΙΙ) --- non-photochemical quenching (NPQ) --- photochemical quenching (qp) --- singlet oxygen (1O2) --- aseptic loosening --- metal ions --- monocytes --- macrophages --- 5-caffeoylquinic acid --- chlorogenic acid --- zinc --- plant phenolic compounds --- oxidative stress

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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

human liver microsomes --- alcohol addiction --- UGT --- ultra-high-pressure liquid chromatography --- adalimumab --- procainamide --- LC-MS/MS --- DA-9805 --- paeonol --- LC-QTOF-MS/MS --- YRA-1909 --- chlorogenic acid --- immunoprecipitation --- Eurycoma longifolia --- CYP --- caffeic acid --- rat --- pharmaceutical excipient --- Korean red ginseng extract --- Stauntonia hexaphylla leaf extract --- bioanalysis --- HPLC-MS/MS --- B6 --- eurycomanone --- bioavailability --- drying technology --- GB3 --- diclofenac --- 129-Glatm1Kul/J --- aglycone --- caffeic acid O-glucuronides --- organic anion transporting polypeptide --- protein precipitation --- metabolic stability --- Fabry disease --- biopharmaceuticals --- imperatorin --- neochlorogenic acid --- gastric ulcer --- saikosaponin a --- hair --- anthraquinone --- acetyl tributyl citrate --- pharmacokinetics --- brain distribution --- mematine --- ethyl glucuronide --- pharmacokinetic --- loxoprofen --- liquid chromatography-quadrupole TOF MS --- glucuronidation --- esomeprazole --- metformin --- cytochrome P450 --- glycoside --- AUDIT score --- protein stability --- efficacy --- LC-HR/MS --- cryptochlorogenic acid --- aceclofenac --- drug interaction --- liquid chromatography-tandem mass spectrometry --- Osthenol --- plasma --- N-acetylprocainamide --- diabetes --- Drugs --- Metabolism. --- Drug metabolism --- Pharmacokinetics