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Evolution. Phylogeny --- Aging --- Human genetics --- Genetic aspects --- Cell Survival. --- Genetics, Medical. --- Human Genetics --- Medical Genetics --- Genetics, Human --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Cell Viability --- Cell Viabilities --- Survival, Cell --- Viabilities, Cell --- Viability, Cell --- Cell Growth Processes --- Human genetics. --- Dissertations --- Genetics --- Genetic aspects. --- Dissertations. --- Genetics. --- Cell Survival --- Genetics, Medical --- Aging - Genetic aspects

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This reprint highlights high-quality original research and review papers that include innovative colloidal drug delivery systems and cutting-edge characterization techniques that significantly contribute to the area of nanomedicine. The results presented are of high interest for specialists from a broad spectrum of fields, including biomedical, pharmaceutical, industrial, and biotechnological spheres.

Technology: general issues --- Chemical engineering --- synthetic antimicrobial polymers --- assembled nanostructures --- surfaces and coatings --- antimicrobial properties --- folate-targeted nanoparticles --- BSA/alginate nanocarriers --- paclitaxel --- cellular uptake --- cell viability --- ciprofibrate --- drug delivery --- Rietveld method --- crystallography --- nanotechnology --- neuropathy --- polymeric nanoparticles --- preclinical investigation --- pharmacokinetics of pregabalin --- antinociceptive effect --- induced sleep --- polymer nanoparticles --- glioma/glioblastoma --- blood–brain barrier (BBB)/blood brain tumour barrier (BBTB) --- nanodiagnostics --- drug delivery and imaging --- nanocrystals --- surface modification --- chemotherapy --- cancer --- cyclosporine A --- ethoxylated fatty acid --- block copolymer --- polymeric micelles --- ocular --- nanoparticles --- natural and synthetic polymers --- drug delivery systems --- biocompatibility --- in vivo tests --- nicarbazin --- DNC --- glycyrrhizic acid --- PVP --- micelles --- coccidiosis --- Pluronic --- F127 --- drug delivery system --- active pharmaceutical ingredient --- antimicrobial activity

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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.

Technology: general issues --- lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV—adeno-associated virus --- gene therapy --- dielectric spectroscopy --- n/a

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This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.

Research & information: general --- film nanocomposite --- essential oil --- supercritical CO2 --- long-term package --- hybrid nanoparticles --- biocompatible polymer --- antimicrobial amphiphiles --- dynamic light scattering --- scanning electron microscopy --- cell viability from counting of colony-forming unities --- antimicrobial activity of nanoparticles --- Escherichia coli --- Staphylococcus aureus --- Candida albicans --- hydrogel --- polyvinyl alcohol --- aliphatic dicarboxylic acids --- sustained release --- linezolid --- equilibrium swelling ratio --- accumulative release --- thermogravimetric analysis --- gram-negative bacteria --- multidrug resistance --- polymer therapeutics --- colistin --- polymyxin B --- nanoliposomes --- MDR-Bacteria --- chitosan --- nanotechnologies --- plant extracts --- agro-food-wastes --- antimicrobial agents --- polymeric nanocarriers --- mixed polymeric micelles --- drug delivery --- antibiotics --- Pluronic F127 --- antimicrobial agent --- polymeric nanomaterial --- self-assembly --- antimicrobial peptide --- silver nanoparticle --- anti-biofilm --- wound healing --- bromelain --- nisin --- bioactivity --- biomedicine --- carrier --- n/a

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ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging.

CTCL --- apoptosis --- cell viability --- c-FLIP --- XIAP --- artemisinin --- SH-SY5Y cells --- hippocampal neurons --- H2O2 --- AMPK pathway --- atherosclerosis --- sphingomyelin synthase 2 --- endothelial dysfunction --- endoplasmic reticulum stress --- β-catenin --- insulin resistance --- cancer --- cardiovascular disease --- neurodegenerative disorders --- exercise --- mitochondria --- oxidative stress --- PGC-1 --- Nrf2 --- UCPs --- ROS --- light --- DNA damage --- evolution --- D-box --- cavefish --- Spalax --- trimethylamine N-oxide --- cardiomyocytes --- cardiotoxicity --- mitochondrial membrane potential --- CORM-2 --- NADPH oxidase --- AP-1 --- HO-1 --- Renal cell carcinoma (RCC) --- reactive oxygen species (ROS) --- glutathione (GSH) metabolism --- cancer therapy --- clear cell RCC --- papillary RCC --- chromophobe RCC --- sarcopenia --- reactive oxygen species --- redox signaling --- antioxidant supplementation --- protein aggregation --- redox --- proteinopathy --- peroxiredoxins --- tumorigenesis --- ROS scavengers --- n/a