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Many research teams are working to demonstrate that microorganisms can be our daily partners, due to the great diversity of biochemical transformations and molecules they are able to produce. This Special Issue highlights several facets of the production of microbial metabolites of interest. From the discovery of new strains or new bioactive molecules issued from novel environments, to the increase in their synthesis by traditional or innovative methods, different levels of biotechnological processes are addressed. Combining the new dimensions of "Omics" sciences, such as genomics, transcriptomics or metabolomics, microbial biotechnologies are opening up incredible opportunities for discovering and improving microorganisms and their production.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- Docosahexaenoic acid (DHA) --- polyunsaturated fatty acids (PUFAs) --- mutant strain --- Aurantiochytrium sp. --- transcriptome --- Xanthomonas campestris pv. campestris --- 6-pentyl-α-pyrone --- antibiosis --- Trichoderma --- secondary metabolites --- antibiofilm --- Gram-negative bacterium --- antibiotic resistance --- natural products --- angucycline --- aquayamycin --- glycosyltransferase --- Lake Baikal --- Streptomyces --- Talaromyces albobiverticillius 30548 --- submerged fermentation --- pigments --- biomass --- optimization --- Box–Behnken experimental design --- response surface modeling --- carnosic acid --- propolis --- antifungal action --- synergy --- Candida albicans --- biofilms --- sponges --- actinomycetes --- cryptic --- Micromonospora --- Nocardia --- Gordonia --- mycolic acid --- LC-HRESIMS --- N-functionalized amines --- N-methylanthranilate --- Corynebacterium glutamicum --- metabolic engineering --- sustainable production of quinoline precursors --- acridone --- quinazoline alkaloid drugs --- SARS-CoV-2 --- Covid-19 --- Mpro --- microbial natural products --- docking --- molecular dynamic simulation --- Serratiochelin A --- Serratiochelin C --- Serratia sp. --- siderophore --- iron --- anticancer --- microbial biotechnology --- degradation --- antibacterial --- S. aureus --- sparkling wine --- second fermentation --- fermentation by-products --- Saccharomyces cerevisiae flor yeast --- proteins --- Scopalina hapalia --- Actinomycetes --- Bacillus --- Fungi --- elastase inhibition --- tyrosinase inhibition --- CDK7 inhibition --- Fyn kinase inhibition --- catalase activation --- sirtuin 1 activation --- Curvularia papendorfii --- endophytic fungi --- human coronavirus HCoV 229E --- Staphylococcus sp. --- MRSA --- antiproliferative activity --- polyhydroxyacid --- kheiric acid --- insect --- mealworm --- gut bacteria --- OSMAC --- cyclic peptides --- biosynthetic pathway --- autophagy inducer --- fermentation --- Lactococcus lactis --- bacteriocin --- culture conditions --- medium compositions --- lactic acid fermentation --- Pediococcus acidilactici PA204 --- simultaneous saccharification and fermentation --- corn stover --- pyocyanin --- maize industry wastewater --- Pseudomonas aeruginosa NEJ01R --- redox metabolite --- response surface analysis --- bioproduction --- valorization --- electrochemical analysis --- sugarcane --- distillery waste water --- molasses spent wash --- vinasse --- fungi --- yeasts --- bioremediation --- COD --- discoloration --- antimicrobial --- antioxidant --- GNPS --- textiles --- cation-exchange resin --- adsorption --- removal --- ammonium --- cell viability --- mutant gdhA P. multocida B:2 --- cyanobacteria --- photosynthesis --- synthetic biology --- systems biology --- genome-scale model --- protoplast fusion --- novel compound discovery --- cell wall-deficiency --- heteroploidy --- Talaromyces --- azaphilone --- marine fungi --- N-threonyl-rubropunctamin --- PP-R --- greener extraction --- red pigments --- fungal pigments --- antinematode compound --- anthelminthic drugs --- marine epiphytic bacteria --- marine biofilm --- marine environment --- parasitic nematode --- Caenorhabditis elegans --- natural colors --- bio-pigments --- quorum sensing --- marine bacteria --- biosynthesis --- biological activities --- industrial applications --- therapeutic insights --- global pigment market --- terpenoids --- sesquiterpene production --- Rhodobacter capsulatus --- β-caryophyllene --- bioactivity --- phytopathogens --- plant pathogenic fungi --- plant growth-promoting bacteria --- microorganisms --- biotechnology --- screening --- production --- extraction --- bioactive properties --- perspectives --- Docosahexaenoic acid (DHA) --- polyunsaturated fatty acids (PUFAs) --- mutant strain --- Aurantiochytrium sp. --- transcriptome --- Xanthomonas campestris pv. campestris --- 6-pentyl-α-pyrone --- antibiosis --- Trichoderma --- secondary metabolites --- antibiofilm --- Gram-negative bacterium --- antibiotic resistance --- natural products --- angucycline --- aquayamycin --- glycosyltransferase --- Lake Baikal --- Streptomyces --- Talaromyces albobiverticillius 30548 --- submerged fermentation --- pigments --- biomass --- optimization --- Box–Behnken experimental design --- response surface modeling --- carnosic acid --- propolis --- antifungal action --- synergy --- Candida albicans --- biofilms --- sponges --- actinomycetes --- cryptic --- Micromonospora --- Nocardia --- Gordonia --- mycolic acid --- LC-HRESIMS --- N-functionalized amines --- N-methylanthranilate --- Corynebacterium glutamicum --- metabolic engineering --- sustainable production of quinoline precursors --- acridone --- quinazoline alkaloid drugs --- SARS-CoV-2 --- Covid-19 --- Mpro --- microbial natural products --- docking --- molecular dynamic simulation --- Serratiochelin A --- Serratiochelin C --- Serratia sp. --- siderophore --- iron --- anticancer --- microbial biotechnology --- degradation --- antibacterial --- S. aureus --- sparkling wine --- second fermentation --- fermentation by-products --- Saccharomyces cerevisiae flor yeast --- proteins --- Scopalina hapalia --- Actinomycetes --- Bacillus --- Fungi --- elastase inhibition --- tyrosinase inhibition --- CDK7 inhibition --- Fyn kinase inhibition --- catalase activation --- sirtuin 1 activation --- Curvularia papendorfii --- endophytic fungi --- human coronavirus HCoV 229E --- Staphylococcus sp. --- MRSA --- antiproliferative activity --- polyhydroxyacid --- kheiric acid --- insect --- mealworm --- gut bacteria --- OSMAC --- cyclic peptides --- biosynthetic pathway --- autophagy inducer --- fermentation --- Lactococcus lactis --- bacteriocin --- culture conditions --- medium compositions --- lactic acid fermentation --- Pediococcus acidilactici PA204 --- simultaneous saccharification and fermentation --- corn stover --- pyocyanin --- maize industry wastewater --- Pseudomonas aeruginosa NEJ01R --- redox metabolite --- response surface analysis --- bioproduction --- valorization --- electrochemical analysis --- sugarcane --- distillery waste water --- molasses spent wash --- vinasse --- fungi --- yeasts --- bioremediation --- COD --- discoloration --- antimicrobial --- antioxidant --- GNPS --- textiles --- cation-exchange resin --- adsorption --- removal --- ammonium --- cell viability --- mutant gdhA P. multocida B:2 --- cyanobacteria --- photosynthesis --- synthetic biology --- systems biology --- genome-scale model --- protoplast fusion --- novel compound discovery --- cell wall-deficiency --- heteroploidy --- Talaromyces --- azaphilone --- marine fungi --- N-threonyl-rubropunctamin --- PP-R --- greener extraction --- red pigments --- fungal pigments --- antinematode compound --- anthelminthic drugs --- marine epiphytic bacteria --- marine biofilm --- marine environment --- parasitic nematode --- Caenorhabditis elegans --- natural colors --- bio-pigments --- quorum sensing --- marine bacteria --- biosynthesis --- biological activities --- industrial applications --- therapeutic insights --- global pigment market --- terpenoids --- sesquiterpene production --- Rhodobacter capsulatus --- β-caryophyllene --- bioactivity --- phytopathogens --- plant pathogenic fungi --- plant growth-promoting bacteria --- microorganisms --- biotechnology --- screening --- production --- extraction --- bioactive properties --- perspectives