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Glutamic Acid --- DNA, Complementary --- Plasmids --- Caspase 3
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The innate immune system is the first line of defense against bacterial and viral infections and sterile inflammation through the recognition of pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs) resulting in the production of proinflammatory and antiviral cytokines and chemokines. Several damage-associated molecular patterns (DAMPs), which were released by passive or active mechanisms under sterile conditions, are additionally recognized by PRRs and can cause or even aggravate the inflammatory response. In this special issue many aspects of innate immunity are summarized. Mechanisms of different DAMPs to induce pro- and anti-inflammatory activities, functions of different immune cells, as well as the crosstalk between coagulation and innate immunity were described. Furthermore, aspects of autoinflammatory diseases, types of programmed cell death pathways, and insect immunity are covered. Finally, therapeutic options for the treatment of diseases related to autoimmunity or infections are suggested. Overall, this special issue presents a broad overview of activities related to sterile inflammation and defense mechanisms of innate immunity.
Medicine --- inflammation --- type I interferons --- interleukin-1β --- crosstalk --- hepatic non-parenchymal cells --- albumin --- chronic liver diseases --- bacteria --- cytomegalovirus --- endothelin receptor --- repurposing --- cell culture --- Drosophila suzukii --- hemocytes --- plasmatocytes --- extracellular traps --- HMGB1 --- RAGE --- TLR4 --- DAMP --- SIRT1 --- α7-nicotinic acetylcholine receptor --- nociceptor --- cancer --- COVID-19 --- proteostasis --- autoinflammation --- ribosomopathies --- proteinopathies --- proteasomopathies --- extracellular RNA --- cytokines --- macrophages --- endothelial cells --- toll-like receptors --- angiogenesis --- γδ T cells --- gamma delta T cells --- proliferation --- macrophage polarization --- neutrophils --- neutrophil extracellular traps --- NETs --- ischemia --- PANoptosis --- PANoptosome --- pyroptosis --- apoptosis --- necroptosis --- inflammatory cell death --- inflammasome --- innate immunity --- infection --- NLR --- caspase --- IRF1 --- ZBP1 --- RIPK1 --- RIPK3 --- MLKL --- NLRP3 --- AIM2 --- Pyrin --- caspase-1 --- ASC --- caspase-8 --- caspase-3 --- caspase-7 --- plasticity --- redundancy --- SMOC1 --- thrombin --- n/a
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Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research. Furthermore, worldwide studies have consistently demonstrated that many crude drugs derived from marine plants contain novel ingredients that may benefit health or can be used in the treatment of diseases; some have been developed into health foods, and some even into drugs. It is expected that there are many substances of marine plant origin that will have medical applications in terms of improving human health and are awaiting discovery.
marine functional foods --- vascular endothelial growth factor receptor-3 --- ultrafiltration --- lung fibrosis --- metabolic instability --- peptide fractions --- cembrane --- 3T3 fibroblasts --- Pinnigorgia sp. --- lymphatic endothelial cells --- bile salts --- caspase-3 --- cytokine --- hepatic stellate cells --- macrophage --- oral squamous cell carcinoma --- anti-inflammation --- MAPK --- fucoidan --- Jaspine B --- ACE-inhibition --- bioactivity --- sulfated galactan --- bioavailability --- ROS --- anti-angiogenesis --- briarellin --- neolignan --- radiation pneumonitis --- Pachyclavularia --- Lumnitzera racemosa --- apoptosis --- phomaketide A --- prodigiosin --- neutrophil --- intestinal permeability --- autophage --- secosterol --- octocoral --- amino acids composition --- phlorotannins --- cardiovascular-health --- antioxidant properties --- marine viva --- green seaweed --- protein enzymatic hydrolysate --- lymphangiogenesis --- edible brown algae --- briarane --- Herbs --- Marine pharmacology. --- Marine algae --- Therapeutic use. --- Sea vegetables --- Seaweed --- Seaweeds --- Vegetables, Sea --- Algae --- Marine plants --- Drugs from the sea --- Marine pharmacognosy --- Materia medica, Marine --- Marine biology --- Materia medica --- Pharmacognosy --- Herb remedies --- Herbal medicine --- Medicinal herbs
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Plant essential oils (PEOs) are hydrophobic liquids that contain volatile chemical components that are derived from various plant parts. They are among the most important plant natural products because of their diverse biological features as well as their therapeutic and nutritional applications. In addition, several aromatic PEOs are used to flavor food and add aromas to incense in the culinary sector. Recently, many PEOs have demonstrated promising antimicrobial activity against different post-harvest diseases and have been considered as possible natural alternatives for chemical treatments. This Special Issue titled “Plant Essential Oil with Biological Activity” provided an overview of several elements of PEOs, including their biological applications, antimicrobial activities, bio-pharmaceutical properties, principal single constituents, and mechanisms of action. This Special Issues fills in knowledge gaps and aids in the advancement of EO applications around the world. This issue contains thirteen research articles and two review papers that address a wide range of topics and applications relevant to the bioactivity of PEOs.
Medicine --- Pharmacology --- allelopathy --- bioherbicides --- volatile oils --- terpenes --- aromatic plants --- Curcuma longa --- essential oil --- extraction methods --- chemical composition --- agri-food industry --- antimicrobial --- herbicidal --- antioxidant --- horseweed --- wavy-leaf fleabane --- sesquiterpenes --- cytotoxicity --- anti-senility --- tomato --- eco-friendly product --- essential oils --- quality preservation --- antioxidants --- damage index --- phytotoxicity --- environmental factors --- Cleome genus --- anti-inflammation --- Oncosiphon suffruticosum --- antibacterial --- tyrosinase inhibition --- sun protection factor --- medicinal plants --- GC-MS --- postharvest diseases --- biological control --- cell membrane permeability --- pale smartweed --- green chemistry --- herbicides --- Jungia rugosa --- Jungia bullata --- Jungia jelskii --- Jungia malvifolia --- Asteraceae --- enantiomers --- Ecuador --- Pulicaria crispa --- chemometric analysis --- chemotype --- Aerva javanica --- sandy soil --- hydrodistillation --- antioxidant activity --- seasonal variation --- angustione --- trichomes --- fruit storage --- natural products --- quality-related attributes --- volatiles --- Anisosciadium lanatum --- HepG2 --- BCL-2 --- CASPASE-3 --- apoptotic markers --- WRKY transcription factor --- Fusarium root rot --- Mentha spicata --- Mentha longifolia GC–MS --- antioxidant enzymes --- antifungal activity --- Annona cherimola --- enantioselective analysis --- antibacterial activity --- anticholinesterase activity --- germacrene D --- Campylobacter jejuni --- antimicrobial activity --- phytopathogens --- food preservatives
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Plant essential oils (PEOs) are hydrophobic liquids that contain volatile chemical components that are derived from various plant parts. They are among the most important plant natural products because of their diverse biological features as well as their therapeutic and nutritional applications. In addition, several aromatic PEOs are used to flavor food and add aromas to incense in the culinary sector. Recently, many PEOs have demonstrated promising antimicrobial activity against different post-harvest diseases and have been considered as possible natural alternatives for chemical treatments. This Special Issue titled “Plant Essential Oil with Biological Activity” provided an overview of several elements of PEOs, including their biological applications, antimicrobial activities, bio-pharmaceutical properties, principal single constituents, and mechanisms of action. This Special Issues fills in knowledge gaps and aids in the advancement of EO applications around the world. This issue contains thirteen research articles and two review papers that address a wide range of topics and applications relevant to the bioactivity of PEOs.
allelopathy --- bioherbicides --- volatile oils --- terpenes --- aromatic plants --- Curcuma longa --- essential oil --- extraction methods --- chemical composition --- agri-food industry --- antimicrobial --- herbicidal --- antioxidant --- horseweed --- wavy-leaf fleabane --- sesquiterpenes --- cytotoxicity --- anti-senility --- tomato --- eco-friendly product --- essential oils --- quality preservation --- antioxidants --- damage index --- phytotoxicity --- environmental factors --- Cleome genus --- anti-inflammation --- Oncosiphon suffruticosum --- antibacterial --- tyrosinase inhibition --- sun protection factor --- medicinal plants --- GC-MS --- postharvest diseases --- biological control --- cell membrane permeability --- pale smartweed --- green chemistry --- herbicides --- Jungia rugosa --- Jungia bullata --- Jungia jelskii --- Jungia malvifolia --- Asteraceae --- enantiomers --- Ecuador --- Pulicaria crispa --- chemometric analysis --- chemotype --- Aerva javanica --- sandy soil --- hydrodistillation --- antioxidant activity --- seasonal variation --- angustione --- trichomes --- fruit storage --- natural products --- quality-related attributes --- volatiles --- Anisosciadium lanatum --- HepG2 --- BCL-2 --- CASPASE-3 --- apoptotic markers --- WRKY transcription factor --- Fusarium root rot --- Mentha spicata --- Mentha longifolia GC–MS --- antioxidant enzymes --- antifungal activity --- Annona cherimola --- enantioselective analysis --- antibacterial activity --- anticholinesterase activity --- germacrene D --- Campylobacter jejuni --- antimicrobial activity --- phytopathogens --- food preservatives
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Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.
total phenolic content --- total flavonoid content --- GC-MS --- DPPH --- antioxidant --- anticancer agent --- anti-inflammatory agent --- gingival fibroblasts --- oral cancer --- natural extract --- Adenosma bracteosum --- extract --- anti-cancer --- cell line --- isolated compounds --- caspase-3 --- bioactive compounds --- metabolites --- wine --- grapes --- breast cancer --- chemoprevention --- chemotherapy --- squamous cell carcinoma --- Moringa oleifera --- 3-hydroxy-β-ionone --- antioxidant activity --- antioxidant enzymes --- anti-proliferative activity --- maslinic acid --- melanoma --- Olea europaea L. --- ROS levels --- photodynamic therapy --- cancer --- photosensitiser --- natural compounds --- Elaeagnus angustifolia --- EMT --- apoptosis --- AKT/PI3K signaling pathway --- human hepatocarcinoma HepG2 cells --- migration activity --- proliferation --- oxidative stress --- ROS level --- uvaol --- lung metastases --- in vivo --- complementary medicine --- medicinal mushrooms --- triterpenoic acid --- tormentic acid --- betulinic acid --- oleanolic acid --- rhodamine B --- cytotoxicity --- hepatocellular carcinoma (HCC) --- Pogostemon cablin (PPa extract) --- cell cycle --- synergism --- natural photosensitive compounds --- anticancer activity --- hypericin --- emodin --- quinizarin --- danthron --- interaction --- DNA --- glioblastoma (GBM) --- lactucopicrin (LCTP) --- temozolomide (TMZ) --- autophagy --- NF-κB --- p62/SQSM1 --- natural product --- therapeutic triglyceride --- xenograft study --- Caveolin-1 --- actin cytoskeleton --- betulin glycoconjugates --- click chemistry --- 1,3-dipolar cycloaddition --- n/a
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Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.
hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing
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Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.
Research & information: general --- Chemistry --- Organic chemistry --- multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2-Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering --- multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2-Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering
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Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.
Research & information: general --- Biology, life sciences --- hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing --- hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing
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