Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The present book recapitulates the articles published within the Special Issue "Cartilage Repair and Regeneration: Focus on Multi-Disciplinary Strategies", Applied Sciences, MDPI, dealing with the innovative multi-disciplinary therapeutic approaches for musculoskeletal diseases. In particular the published studies space from advanced 3D bioprinting technology to obtain a scaffold with different zonal cell densities, and biphasic scaffold (ChondroMimetic) construction, pass through the comparison of different techniques for cartilage regeneration such as of mosaicplasty and matrix-assisted autologous chondrocyte transplantation (MACT) and histopathological features of osteochondral units, and end with the considerations regarding development of bioreactors able to mimic the biomechanical load on chondrocytes in vitro, giving some interesting insights in this specific scientific field.

Medicine --- Pharmacology --- mesenchymal stem cells --- tissue engineering --- chondrogenesis --- osteoarthritis --- bioreactor --- mechanical stimuli --- physical stimulation --- compression --- shear stress --- hydrostatic pressure --- osteonecrosis --- osteochondral unit --- tissue remodelling and repair --- multi-targeted approach --- mosaicplasty --- MACT --- ACI --- scaffold --- osteochondral autologous transplantation --- OAT --- cartilage --- knee --- biphasic scaffold --- osteochondral defect --- cartilage repair --- quantitative MRI --- calcium phosphate --- bioprinting --- biofabrication --- articular cartilage --- human chondrocytes --- cell density --- cell gradient --- 3D bioprinting --- ChondroMimetic --- cartilage regeneration --- osteochondral repair --- matrix-assisted autologous chondrocyte transplantation --- magneto-responsive techniques --- biomechanical stimuli --- multi-disciplinary approach --- mesenchymal stem cells --- tissue engineering --- chondrogenesis --- osteoarthritis --- bioreactor --- mechanical stimuli --- physical stimulation --- compression --- shear stress --- hydrostatic pressure --- osteonecrosis --- osteochondral unit --- tissue remodelling and repair --- multi-targeted approach --- mosaicplasty --- MACT --- ACI --- scaffold --- osteochondral autologous transplantation --- OAT --- cartilage --- knee --- biphasic scaffold --- osteochondral defect --- cartilage repair --- quantitative MRI --- calcium phosphate --- bioprinting --- biofabrication --- articular cartilage --- human chondrocytes --- cell density --- cell gradient --- 3D bioprinting --- ChondroMimetic --- cartilage regeneration --- osteochondral repair --- matrix-assisted autologous chondrocyte transplantation --- magneto-responsive techniques --- biomechanical stimuli --- multi-disciplinary approach

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal criteria of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Bone regeneration. --- Cartilage Regeneration. --- Bone --- Bones --- Bone remodeling --- Regeneration (Biology) --- Regeneration --- Stem cells. --- Biomedical engineering. --- Orthopedic surgery. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering. --- Biomedical Engineering and Bioengineering. --- Surgical Orthopedics. --- Operative orthopedics --- Orthopedics --- Surgery, Operative --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Regenerative medicine. --- Tissue engineering. --- Orthopedics. --- Orthopaedics --- Orthopedia --- Surgery --- Biomedical engineering --- Regenerative medicine --- Tissue culture

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The present book recapitulates the articles published within the Special Issue "Cartilage Repair and Regeneration: Focus on Multi-Disciplinary Strategies", Applied Sciences, MDPI, dealing with the innovative multi-disciplinary therapeutic approaches for musculoskeletal diseases. In particular the published studies space from advanced 3D bioprinting technology to obtain a scaffold with different zonal cell densities, and biphasic scaffold (ChondroMimetic) construction, pass through the comparison of different techniques for cartilage regeneration such as of mosaicplasty and matrix-assisted autologous chondrocyte transplantation (MACT) and histopathological features of osteochondral units, and end with the considerations regarding development of bioreactors able to mimic the biomechanical load on chondrocytes in vitro, giving some interesting insights in this specific scientific field.

mesenchymal stem cells --- tissue engineering --- chondrogenesis --- osteoarthritis --- bioreactor --- mechanical stimuli --- physical stimulation --- compression --- shear stress --- hydrostatic pressure --- osteonecrosis --- osteochondral unit --- tissue remodelling and repair --- multi-targeted approach --- mosaicplasty --- MACT --- ACI --- scaffold --- osteochondral autologous transplantation --- OAT --- cartilage --- knee --- biphasic scaffold --- osteochondral defect --- cartilage repair --- quantitative MRI --- calcium phosphate --- bioprinting --- biofabrication --- articular cartilage --- human chondrocytes --- cell density --- cell gradient --- 3D bioprinting --- ChondroMimetic --- cartilage regeneration --- osteochondral repair --- matrix-assisted autologous chondrocyte transplantation --- magneto-responsive techniques --- biomechanical stimuli --- multi-disciplinary approach

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Research & information: general --- Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering --- Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering