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"Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts"--

Heart valve prosthesis. --- Heart valves. --- Heart Valves. --- Heart Valve Diseases. --- Heart Valvular Disease --- Valvular Heart Diseases --- Disease, Heart Valvular --- Heart Disease, Valvular --- Heart Valve Disease --- Heart Valvular Diseases --- Valve Disease, Heart --- Valvular Disease, Heart --- Valvular Heart Disease --- Cardiac Valves --- Cardiac Valve --- Heart Valve --- Valve, Cardiac --- Valve, Heart --- Valves, Cardiac --- Valves, Heart --- Cardiac valves --- Heart --- Prosthetic heart valves --- Prosthesis --- Valves

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Cardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications.

Cardiovascular system -- Surgery. --- Heart valves -- Diseases. --- Heart valves -- Surgery. --- Medicine. --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Heart valves. --- Heart --- Surgery. --- Cardiac surgery --- Open-heart surgery --- Cardiac valves --- Valves, Heart --- Diseases --- Surgery --- Valves --- Cardiology. --- Cardiac surgery. --- Biomedicine. --- Biomedicine general. --- Cardiac Surgery. --- Internal medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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The surgical treatment of the aortic valve and root disease, organic and ischemic mitral regurgitation, and endocarditis has made great strides. Still, there is the well-known dilemma: on the one hand the need for anticoagulation in patients with mechanical valves that otherwise guarantee long-term functioning and, on the other, the unpredictable durability of biological substitutes and of valve repair procedures which, per se, do not require anticoagulation. The choice of procedure is determined by factors such as patients' age, metabolic and bleeding disorders, and bleeding preconditions, as well as such critical issues as the desire to bear children in young women. The book contains a collection of proceedings of The Berlin Heart Valve Symposium which was held in November 2008. It focuses on current surgical approaches to and evolving trends in aortic valve repair, aortic root and valve replacement with pulmonary autograft, aortic allograft, stentless and stented bioprostheses.  Further contributions will deal with recent advances in catheter-based percutaneous and transapical techniques, ablation techniques for atrial fibrillation, tissue engineering of heart valves, multi-modality imaging, and anticoagulation.

Embryonic Development. --- Fetal Diseases. --- Heart -- Diseases. --- Heart Diseases. --- Aortic Valve --- Bioprosthesis --- Heart Valve Prosthesis Implantation --- Blood Vessel Prosthesis Implantation --- Prosthesis Implantation --- Vascular Grafting --- Heart Valves --- Prostheses and Implants --- Cardiac Surgical Procedures --- Surgical Procedures, Operative --- Equipment and Supplies --- Vascular Surgical Procedures --- Cardiovascular Surgical Procedures --- Thoracic Surgical Procedures --- Heart --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cardiovascular System --- Anatomy --- Surgery - General and By Type --- Surgery & Anesthesiology --- Health & Biological Sciences --- Aorta --- Heart valves --- Cardiovascular instruments, Implanted --- Surgery --- Implanted cardiovascular instruments --- Cardiac valves --- Valves, Heart --- Valves --- Medicine. --- Cardiology. --- Cardiac surgery. --- Medicine & Public Health. --- Cardiac Surgery. --- Biomedical engineering --- Electronics in cardiology --- Implants, Artificial --- Arteries --- Blood --- Chest --- Circulation --- Surgery. --- Internal medicine --- Cardiac surgery --- Open-heart surgery --- Diseases

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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

Research & information: general --- Biology, life sciences --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling

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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling