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This reprint contains original research and review articles describing recent advances in our understanding of the transcriptional regulation of cardiac development and disease mechanisms. All articles were originally published in the International Journal of Molecular Sciences (IJMS).

pluripotent stem cells --- cardiomyocytes --- cardiac tissue engineering --- human heart --- tissue maturation --- Wilms’ tumor suppressor 1 --- cardiomyocyte differentiation --- mouse embryonic stem cells --- myocardial infarction --- YAP --- TEAD1 --- Toll-like receptor --- heart --- TLR4 --- cardiomyocyte --- innate immune responses --- Wilms’ tumor suppressor 1 (Wt1) --- cardiac development --- coronary vessel formation --- transcriptional regulation --- cardiac malformation --- epicardium --- epicardial derived cells (EPDCs) --- epithelial mesenchymal transition (EMT) --- cardiac cell fate --- regeneration --- arrhythmogenic cardiomyopathy (ACM) --- lamin A/C --- atomic force microscopy (AFM) --- cell–cell adhesion --- neonatal rat ventricular fibroblasts (NRVF) --- tunneling nanotubes (TNT) --- gene therapy --- cardiovascular diseases --- cardiac regeneration --- cardiac reprogramming --- therapeutic angiogenesis --- growth factors --- reactive oxygen species --- apoptosis --- Bmp signaling --- Hand1 --- Smad --- heart development --- SH3BGR --- cardiac hypertrophy --- SRF signaling --- Hippo signaling --- cardiomyogenic differentiation --- cardiac mesenchymal stromal cell --- hydrogels --- histone deacetylase inhibitors --- translational studies --- gene expression and regulation --- cardiomyopathy --- heart failure --- reverse remodelling --- left ventricular assist device --- n/a --- Wilms' tumor suppressor 1 --- Wilms' tumor suppressor 1 (Wt1) --- cell-cell adhesion

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The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian ‘enterprise,’ but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.

Public health & preventive medicine --- transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct

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• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian ‘enterprise,’ but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.

Public health & preventive medicine --- transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct --- transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct