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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Cancer Epidemiology and Prevention --- cancer genetics --- Cancer Imaging and Image-directed Interventions --- Cancer Immunity and Immunotherapy --- Molecular Targets and Therapeutics --- Gastrointestinal cancers --- Genitourinary oncology --- head and neck cancer --- Hematologic Malignancies Metabolism --- molecular and cellular oncology --- Neuro-Oncology and Neurosurgical Oncology --- pediatric oncology --- Pharmacology of Anti-Cancer Drugs --- Radiation Oncology --- surgical oncology --- thoracic oncology --- women's cancer

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The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

STRIPAK --- skin cancer --- n/a --- Lats2 --- transcription --- myofibroblast --- epigenetic --- Hippo --- cancer immunity --- TAZ --- Taz --- TAZ (transcriptional co-activator with PDZ-binding motif) --- adaptive immunity --- fibroblasts --- innate immunity --- LATS --- MST (mammalian STE20-like protein kinase) --- phosphorylation --- stem cells --- wound healing --- signal transduction --- angiogenesis --- LATS1/2 --- EMT --- protein-protein interactions --- structure biology --- Hippo pathway --- hippo pathway --- autoimmunity --- Mps one binder --- YAP/TAZ --- GPCR --- fibrosis --- MST1/2 --- YAP (yes-associated protein) --- YAP --- Yap --- protein kinase --- LATS (large tumor suppressor kinase) --- peripheral nerve sheath tumor --- signal cross-talk --- stem cell --- skin development --- STK38 --- tumorigenesis --- NDR --- schwannoma --- G protein-coupled receptor --- anti-cancer therapy --- feedback loops --- vascular mimicry --- castration resistance --- chromatin --- Hippo signalling --- ECM --- MST --- prostate cancer --- TEAD --- cancer --- zebrafish