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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

big data --- cancer genomics --- cancer genomics data analysis --- HPC (high performance computing) --- humanizing big data

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Oncology --- big data --- cancer genomics --- cancer genomics data analysis --- HPC (high performance computing) --- humanizing big data

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This ebook includes original research articles and reviews to update readers on the state of the art systems approach to not only discover novel diagnostic and prognostic biomarkers for several cancer types, but also evaluate methodologies to map out important genomic signatures. In addition, therapeutic targets and drug repurposing have been emphasized for a variety of cancer types. In particular, new and established researchers who desire to learn about cancer systems biology and why it is possibly the leading front to a personalized medicine approach will enjoy reading this book.

Sestrin2 --- lung cancer --- knockdown --- cancer progression --- bioinformatics --- patient survival --- lung adenocarcinoma --- circulating miR-1246 --- glycosaminoglycan binding --- prognosis --- PI3K–Akt signaling pathways --- TargetScan --- UBE2C --- cancer systems biology --- experimental model systems --- next-generation sequencing --- single-cell sequencing --- patient-derived xenografts --- patient-derived organoids --- triple-negative breast cancer --- personalized medicine --- computational methods --- drug repurposing --- clinical trials --- cancer stem cells --- ETS --- Elk-1 --- stem cell --- microarray --- brain-tumor-initiating cell (BTIC) --- pancreatic cancer --- systems biology --- omics --- biomarker --- genomics --- transcriptomics --- proteomics --- metabolomics --- glycomics --- metagenomics --- Ets --- PEA3 --- Ets-1 --- glioma --- optical genome mapping --- solid tumors --- cancer genomics --- breast --- ovarian --- cancer --- TCGA --- non-small-cell lung cancer --- lung adenocarcinoma (LUAD) --- lung squamous cell carcinoma (LUSC) --- differential expression --- SNV --- CNV --- risk group --- signature --- survival --- renal cancers --- protein interactome --- diagnostic biomarker --- prognostic biomarker --- virtual screening --- docking --- acute myeloid leukemia --- Boolean model --- drug resistance --- network --- n/a --- PI3K-Akt signaling pathways

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Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.

Medicine --- renal cell carcinoma --- team medicine --- translational research --- community practice --- clinical trials --- geriatric oncology --- older adults --- cancer clinical trials --- recruitment --- community --- team science --- bladder cancer --- urothelial carcinoma --- COVID-19 --- team-based medicine --- colorectal cancer --- precisian medicine --- academic and community oncology --- cancer center --- lung cancer --- lung cancer screening --- low-dose CT scans --- cancer prevention --- smoking cessation --- tobacco control --- national guidelines for screening and prevention --- pharmaceutical aids to smoking cessation --- non-small cell lung cancer --- driver mutations --- testing rates --- receptor tyrosine kinases --- actionable mutations --- next-generation sequencing --- fast-and-frugal trees --- personalized medicine --- minorities --- ethnicity --- race --- breast cancer --- research --- HER2-directed therapy --- community oncology --- academic cancer center --- precision medicine --- cancer genetics --- cancer genomics --- small cell lung cancer --- immunotherapy --- epithelial ovarian cancer --- frontline treatment --- surgical debulking --- adjuvant chemotherapy --- maintenance therapy --- PARP inhibitor --- genetics counseling --- clinical research --- oropharyngeal cancer --- concurrent chemoradiation therapy --- human papillomavirus --- feeding tube dependency --- value-based care --- value-based cancer care --- oncology pathways --- Early Recovery After Surgery (ERAS) --- team-based care --- oncology medical home --- integrated cancer care --- supportive care pathways --- surgical pathways --- cancer care plans --- renal cell carcinoma --- team medicine --- translational research --- community practice --- clinical trials --- geriatric oncology --- older adults --- cancer clinical trials --- recruitment --- community --- team science --- bladder cancer --- urothelial carcinoma --- COVID-19 --- team-based medicine --- colorectal cancer --- precisian medicine --- academic and community oncology --- cancer center --- lung cancer --- lung cancer screening --- low-dose CT scans --- cancer prevention --- smoking cessation --- tobacco control --- national guidelines for screening and prevention --- pharmaceutical aids to smoking cessation --- non-small cell lung cancer --- driver mutations --- testing rates --- receptor tyrosine kinases --- actionable mutations --- next-generation sequencing --- fast-and-frugal trees --- personalized medicine --- minorities --- ethnicity --- race --- breast cancer --- research --- HER2-directed therapy --- community oncology --- academic cancer center --- precision medicine --- cancer genetics --- cancer genomics --- small cell lung cancer --- immunotherapy --- epithelial ovarian cancer --- frontline treatment --- surgical debulking --- adjuvant chemotherapy --- maintenance therapy --- PARP inhibitor --- genetics counseling --- clinical research --- oropharyngeal cancer --- concurrent chemoradiation therapy --- human papillomavirus --- feeding tube dependency --- value-based care --- value-based cancer care --- oncology pathways --- Early Recovery After Surgery (ERAS) --- team-based care --- oncology medical home --- integrated cancer care --- supportive care pathways --- surgical pathways --- cancer care plans