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Cancer drug resistance
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ISBN: 1280831987 9786610831982 1597450359 1588295303 1617376221 Year: 2006 Publisher: Totowa, N.J. : Humana Press,

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As genomic techniques gradually reveal the ability of malignant cells to respond to chemical and biological insults with remarkable flexibility of phenotype, it becomes clear that much remains to be done to control and eliminate such cells. In Cancer Drug Resistance, leading scientists from the best academic institutions and industrial laboratories summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to a wide variety of anticancer therapeutics, as well as suggest new approaches to the biology of drug resistance that may afford new therapeutic opportunities. The authors review physiological resistance based tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin®. Authoritative and insightful, Cancer Drug Resistance offers basic and clinical investigators a state-of-the-art synthesis of the many faceted research now available on the biology and genetics of tumor resistance, as well as exciting new approaches to its prevention and eradication.


Book
Biological mechanisms and the advancing approaches to overcoming cancer drug resistance
Authors: ---
ISBN: 0128213116 0128213108 9780128213117 9780128213100 Year: 2021 Publisher: Amsterdam


Book
New targeting in the reversal of resistant glioblastomas
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ISBN: 0128232765 0128225270 9780128225271 9780128232767 Year: 2021 Publisher: London, United Kingdom

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Epigenetic regulation in overcoming chemoresistance
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ISBN: 0128236841 012823685X 9780128236857 9780128236840 Year: 2021 Publisher: London Academic Press

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"Epigenetic Regulation in Overcoming Chemoresistance, Volume 16, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers"--


Book
Overcoming ovarian cancer chemoresistance
Authors: ---
ISBN: 9780128198414 0128198419 0128198400 9780128198407 Year: 2021 Publisher: London

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Resistance to Molecular Therapies for Hepatocellular Carcinoma
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ISBN: 3319561979 3319561960 Year: 2017 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.


Book
Drug resistance in colorectal cancer
Authors: ---
ISBN: 0128199385 0128199377 9780128199381 9780128199374 Year: 2020 Publisher: London Academic Press

Mechanisms of drug resistance in neoplastic cells
Authors: ---
ISBN: 0127633626 1322280177 1483220753 Year: 1988 Volume: vol 9 Publisher: Orlando London Tokyo Academic Press


Book
Resistance to Targeted Therapies in Breast Cancer
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ISBN: 3319701428 331970141X Year: 2017 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy.  .


Book
Resistance to Ibritumomab in Lymphoma
Authors: ---
ISBN: 331978238X 3319782371 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This volume, in discussing resistance to ibritumomab, will focus on the mechanism, hematological aspects, radiological and nuclear medicine aspects, and medical physics that deal with radiation dosimetry, and will outline future prospects for overcoming resistance and enhancing efficacy of ibritumomab.

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