Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Plant-based diets contain a plethora of metabolites that may impact on health and disease prevention. Most are focused on the potential bioactivity and nutritional relevance of several classes of phytochemicals, such as polyphenols, flavonoids, carotenoids, phyto-oestrogens, and frucrooligo-saccharides. These compounds are found in fruit, vegetables, and herbs. Daily intakes of some of these compounds may exceed 100 mg. Moreover, intestinal bacterial activity may transform complex compounds such as anthocyanins, procyanidins, and isoflavones into simple phenolic metabolites. The colon is thus a rich source of potentially active phenolic acids that may impact both locally and systemically on gut health. Further, nondigestible fiber (prebiotics) are dietary substrates that selectively promote proliferation and/or activity of health-promoting bacterial populations in the colon. Prebiotics, such as inulin, raffinose, and stachyose, have a proven ability to promote the abundance of intestinal bacterial populations, which may provide additional health benefits to the host. Further, various pulse seed soluble (fiber) extracts are responsible for improving gastrointestinal motility, intestinal functionality and morphology, and mineral absorption. Studies indicated that the consumption of seed origin soluble extracts can upregulate the expression of BBM proteins that contribute for digestion and absorption of nutrients.

Research & information: general --- Biology, life sciences --- Food & society --- intra amniotic (in ovo) administration --- zinc gene expression --- iron gene expression --- brush border membrane functional genes --- intestinal bacterial populations --- villus surface area --- cichoric acid --- metal complexes --- cytotoxicity --- cancer --- bacterial strains --- fungi --- human cell culture --- lactic acid bacteria --- probiotic --- acrylamide --- viability --- flow cytometry --- mesotrione --- traumatic acid --- breast cancer --- herbicide --- antioxidant --- oxidative stress --- bifidobacteria --- colon --- fermentation --- microbiota --- prebiotic --- SHIME® --- artichoke --- intestinal microbiota --- vegetable drink --- beneficial microorganisms --- cereal --- legume --- pseudocereal --- fruit --- synbiotic --- microbiome --- SCFA --- pectin --- rhamnogalacturonan --- transepithelial electrical resistance (TEER) --- pea --- phytate --- iron --- bioavailability --- bio active compound --- in vivo --- Gallus gallus --- brush border membrane --- oats --- celiac disease --- non-celiac gluten sensitivity --- gluten-free --- SCFAs --- teff --- staple food crops --- prebiotics --- probiotics --- iron deficiency --- zinc deficiency --- gut microbiota --- intrauterine growth restriction (IUGR) --- fructose --- dexamethasone --- intestinal gluconeogenesis --- plant origin --- bio-active compounds --- intestine --- intra amniotic (in ovo) administration --- zinc gene expression --- iron gene expression --- brush border membrane functional genes --- intestinal bacterial populations --- villus surface area --- cichoric acid --- metal complexes --- cytotoxicity --- cancer --- bacterial strains --- fungi --- human cell culture --- lactic acid bacteria --- probiotic --- acrylamide --- viability --- flow cytometry --- mesotrione --- traumatic acid --- breast cancer --- herbicide --- antioxidant --- oxidative stress --- bifidobacteria --- colon --- fermentation --- microbiota --- prebiotic --- SHIME® --- artichoke --- intestinal microbiota --- vegetable drink --- beneficial microorganisms --- cereal --- legume --- pseudocereal --- fruit --- synbiotic --- microbiome --- SCFA --- pectin --- rhamnogalacturonan --- transepithelial electrical resistance (TEER) --- pea --- phytate --- iron --- bioavailability --- bio active compound --- in vivo --- Gallus gallus --- brush border membrane --- oats --- celiac disease --- non-celiac gluten sensitivity --- gluten-free --- SCFAs --- teff --- staple food crops --- prebiotics --- probiotics --- iron deficiency --- zinc deficiency --- gut microbiota --- intrauterine growth restriction (IUGR) --- fructose --- dexamethasone --- intestinal gluconeogenesis --- plant origin --- bio-active compounds --- intestine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.

Research & information: general --- Chemistry --- positron emission tomography (PET) --- pyrazoles --- fluorine-18 --- radionuclides --- PET probes --- imaging pharmaceuticals --- hypopharyngeal cancer --- 188Re-liposome --- repeated therapy --- NGS --- microRNA --- aprepitant --- radiopharmaceuticals --- neurokinin 1 receptor antagonist --- radionuclide chelators --- kidney uptake --- cleavable linkers --- neutral endopeptidase (NEP) --- renal brush border enzymes --- prostate-specific membrane antigen (PSMA) --- cancer imaging and therapy --- somatostatin analogs --- radiolabeling --- radionuclide therapy --- imaging --- adrenergic receptor --- positron emission tomography --- radiotracer --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- targeted radiotherapy --- lutetium-177 --- EpCAM --- radionuclide --- SPECT --- iodine --- PIB --- breast --- cancer --- PET --- target-specific biomolecules --- immunoPET imaging pharmaceuticals --- production processes --- 124I-labeled monoclonal antibodies --- radiotracers --- AAZTA --- scandium-44 --- FAP --- SA --- DPP --- PREP --- radioiodine labeling --- radioiodination --- biomolecules --- peptides --- proteins --- monoclonal antibodies --- 123,124,125,131I-labeled molecules and biomolecules --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

chitosan --- intestinal epithelial cells --- ocular delivery --- amphiphilic polymers --- cornea --- tight junction modulator --- cyclodextrin --- permeability --- gemini surfactant --- transferrin --- compound 48/80 --- epithelial permeability --- cervicovaginal tumors --- nanoparticles --- confocal laser scanning microscopy --- safety --- formulation --- salcaprozate sodium --- intestinal absorption --- FITC-dextran --- curcumin --- block copolymers --- nasal vaccination --- whole leaf --- brush border --- ocular drug delivery --- vaccine adjuvant --- nanoparticle --- nasal delivery --- efflux --- permeation enhancers --- absorption enhancers --- nose to brain delivery --- small intestine --- epithelium --- CNS disorders --- absorption modifying excipients --- insulin --- absorption enhancer --- gel --- intestinal delivery --- thermogel system --- Caco-2 --- biocompatibility studies --- absorption enhancement --- man --- PN159 --- poorly absorbed drug --- tryptophan --- tight junction --- oral macromolecule delivery --- penetration enhancer --- intestinal permeation enhancers --- nanocrystals --- simvastatin --- nanomedicine --- enterocyte --- N-dodecyl-?-D-maltoside (DDM) --- cell-penetrating peptide --- quaternization --- KLAL --- nasal --- nasal permeability --- transmucosal drug delivery --- Caco-2 cells --- mast cell activator --- penetration enhancers --- drug delivery --- nose-to-brain --- bioenhancer --- polymeric micelles --- mucoadhesion --- cell-penetrating peptide (CPP) --- simulated intestinal fluid --- vaginal delivery --- nasal formulation --- pharmacokinetic interaction --- sodium caprate --- clinical trial --- transmucosal permeation --- drug absorption enhancer --- sugar-based surfactants --- nanocapsules --- imatinib --- teriparatide --- osteoporosis --- hydrophobization --- F-actin --- combined microsphere --- transepithelial electrical resistance --- oral delivery --- ocular conditions --- metabolism --- antimicrobial peptide --- permeation enhancer --- drug administration --- antiepileptic drug --- amino acid --- in vivo studies --- sodium cholate (NaC) --- epithelial transport --- preclinical --- nose to brain transport --- pharmacokinetics --- chitosan derivatives --- ophthalmology --- tight junctions --- sheep --- cationic functionalization --- GLP-1 --- pulmonary --- and liposome --- cytochrome P450 --- claudin --- P-glycoprotein --- in situ hydrogel --- mucoadhesiveness --- PTH 1-34 --- Aloe vera --- oral peptides