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Throughout the twentieth century, neuronal researchers knew the adult human brain to be a thoroughly fixed and immutable cellular structure, devoid of any developmental potential. Plastic Reason is a study of the efforts of a few Parisian neurobiologists to overturn this rigid conception of the central nervous system by showing that basic embryogenetic processes-most spectacularly the emergence of new cellular tissue in the form of new neurons, axons, dendrites, and synapses-continue in the mature brain. Furthermore, these researchers sought to demonstrate that the new tissues are still unspecific and hence literally plastic, and that this cellular plasticity is constitutive of the possibility of the human. Plastic Reason, grounded in years of fieldwork and historical research, is an anthropologist's account of what has arguably been one of the most sweeping events in the history of brain research-the highly contested effort to consider the adult brain in embryogenetic terms. A careful analysis of the disproving of an established truth, it reveals the turmoil that such a disruption brings about and the emergence of new possibilities of thinking and knowing.

Neuroplasticity. --- Brain --- Developmental neurobiology. --- Developmental neurology --- Neurogenesis --- Developmental biology --- Embryology --- Neurobiology --- Nervous system --- Neuroplasticity --- Cerebrum --- Mind --- Central nervous system --- Head --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Research --- History. --- Evolution --- adult brain. --- brain research. --- brain science. --- cellular plasticity of the brain. --- central nervous system. --- developmental neurobiology. --- embryogenetic processes in the adult brain. --- evolution. --- history of brain science. --- history of medicine. --- human brain. --- lifelong development. --- mature brain development. --- medical anthropology. --- nervous system. --- neurobiology. --- neurology. --- neuronal research. --- neuroplasticity. --- neuroscience research. --- plasticity of human brain.

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A cross-disciplinary approach is offered to consider the challenge of emerging technologies designed to enhance human bodies and minds. Perspectives from philosophy, ethics, law, and policy are applied to a wide variety of enhancements, including integration of technology within human bodies, as well as genetic, biological, and pharmacological modifications. Humans may be permanently or temporarily enhanced with artificial parts by manipulating (or reprogramming) human DNA and through other enhancement techniques (and combinations thereof). We are on the cusp of significantly modifying (and perhaps improving) the human ecosystem. This evolution necessitates a continuing effort to re-evaluate current laws and, if appropriate, to modify such laws or develop new laws that address enhancement technology. A legal, ethical, and policy response to current and future human enhancements should strive to protect the rights of all involved and to recognize the responsibilities of humans to other conscious and living beings, regardless of what they look like or what abilities they have (or lack). A potential ethical approach is outlined in which rights and responsibilities should be respected even if enhanced humans are perceived by non-enhanced (or less-enhanced) humans as “no longer human” at all.

Technology: general issues --- cyborgs --- implants --- posthumans --- Homo technologicus --- Homo sapiens --- human-machine interaction --- cyborg --- enhancement technology --- prosthesis --- brain-computer interface --- new senses --- identity --- neuroprosthesis --- patent law --- copyright law --- cognitive liberty --- international law --- evolution --- cultural technology --- human enhancement --- engineering --- bionics --- biotechnology --- disability --- marketing --- cultural studies --- Disney --- supercrip --- human enhancements --- autonomy --- informed consent --- moral enhancement --- vulnerability --- numeric identity --- military ethics --- human-machine interaction --- upgrading humans --- superhumans --- gene editing --- embryo selection --- CRISPR --- cognitive enhancement --- assisted reproductive technologies (ART) --- public opinion --- in vitro gametogenesis (IVG) --- genome-wide association studies (GWAS) --- brain-computer interface (BCI) --- brain-machine interface (BMI) --- ethical --- legal and social Issues (ELSI) --- neuroethics --- narrative review --- intellectual property --- copyright --- neuropolitics --- brain science --- voting --- human rights --- ethics --- discrimination --- racism --- speciesism --- ableism --- human-robot interaction --- mind --- sense of agency --- alienation --- cyborgs --- implants --- posthumans --- Homo technologicus --- Homo sapiens --- human-machine interaction --- cyborg --- enhancement technology --- prosthesis --- brain-computer interface --- new senses --- identity --- neuroprosthesis --- patent law --- copyright law --- cognitive liberty --- international law --- evolution --- cultural technology --- human enhancement --- engineering --- bionics --- biotechnology --- disability --- marketing --- cultural studies --- Disney --- supercrip --- human enhancements --- autonomy --- informed consent --- moral enhancement --- vulnerability --- numeric identity --- military ethics --- human-machine interaction --- upgrading humans --- superhumans --- gene editing --- embryo selection --- CRISPR --- cognitive enhancement --- assisted reproductive technologies (ART) --- public opinion --- in vitro gametogenesis (IVG) --- genome-wide association studies (GWAS) --- brain-computer interface (BCI) --- brain-machine interface (BMI) --- ethical --- legal and social Issues (ELSI) --- neuroethics --- narrative review --- intellectual property --- copyright --- neuropolitics --- brain science --- voting --- human rights --- ethics --- discrimination --- racism --- speciesism --- ableism --- human-robot interaction --- mind --- sense of agency --- alienation

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A cross-disciplinary approach is offered to consider the challenge of emerging technologies designed to enhance human bodies and minds. Perspectives from philosophy, ethics, law, and policy are applied to a wide variety of enhancements, including integration of technology within human bodies, as well as genetic, biological, and pharmacological modifications. Humans may be permanently or temporarily enhanced with artificial parts by manipulating (or reprogramming) human DNA and through other enhancement techniques (and combinations thereof). We are on the cusp of significantly modifying (and perhaps improving) the human ecosystem. This evolution necessitates a continuing effort to re-evaluate current laws and, if appropriate, to modify such laws or develop new laws that address enhancement technology. A legal, ethical, and policy response to current and future human enhancements should strive to protect the rights of all involved and to recognize the responsibilities of humans to other conscious and living beings, regardless of what they look like or what abilities they have (or lack). A potential ethical approach is outlined in which rights and responsibilities should be respected even if enhanced humans are perceived by non-enhanced (or less-enhanced) humans as “no longer human” at all.

Technology: general issues --- cyborgs --- implants --- posthumans --- Homo technologicus --- Homo sapiens --- human-machine interaction --- cyborg --- enhancement technology --- prosthesis --- brain–computer interface --- new senses --- identity --- neuroprosthesis --- patent law --- copyright law --- cognitive liberty --- international law --- evolution --- cultural technology --- human enhancement --- engineering --- bionics --- biotechnology --- disability --- marketing --- cultural studies --- Disney --- supercrip --- human enhancements --- autonomy --- informed consent --- moral enhancement --- vulnerability --- numeric identity --- military ethics --- human–machine interaction --- upgrading humans --- superhumans --- gene editing --- embryo selection --- CRISPR --- cognitive enhancement --- assisted reproductive technologies (ART) --- public opinion --- in vitro gametogenesis (IVG) --- genome-wide association studies (GWAS) --- brain–computer interface (BCI) --- brain–machine interface (BMI) --- ethical --- legal and social Issues (ELSI) --- neuroethics --- narrative review --- intellectual property --- copyright --- neuropolitics --- brain science --- voting --- human rights --- ethics --- discrimination --- racism --- speciesism --- ableism --- human–robot interaction --- mind --- sense of agency --- alienation --- n/a --- brain-computer interface --- brain-computer interface (BCI) --- brain-machine interface (BMI) --- human-robot interaction

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