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The pestiviruses encompass some of the most economically important viral infections in the cattle, swine, and sheep industries worldwide. Discovered more than 70 years ago, bovine viral diarrhea virus (BVDV) and classical swine fever virus (CSFV) were long the main concern, but many new pestiviruses have emerged in recent years, which may also present additional threats to biosecurity and food safety. This issue brings together contributions from multiple disciplines – virology, immunology, veterinary clinical medicine, epidemiology, and pathology – on the subject of BVDV and related pestiviruses, and cover host–virus interactions, virus–cell interactions, cross-species transmission as well as the role of wildlife species as reservoirs of some of the pestiviruses.

Research & information: general --- Biology, life sciences --- Linda virus --- serological profile --- virus neutralization assay --- virus pathogenicity --- humoral immune response --- pestivirus --- pig --- APPV --- phylogenetic analysis --- Italy --- bvdv --- epidemiology --- reindeer --- border disease virus --- Norway --- Pestivirus --- BVDV --- CD46 --- life cell imaging --- attachment --- surface transport --- experimental infection --- natural infection --- pigs --- bovine viral diarrhoea virus --- persistent testicular infection --- prolonged testicular infection --- bovine --- testes --- semen --- wild boar --- ML tree --- Clade --- Bungowannah virus --- pestivirus F --- ruminant infection --- foetus --- porcine --- real-time PCR --- serology --- virology --- bovine viral diarrhea virus --- cytopathic BVDV --- immunosuppression --- lymphocyte apoptosis --- monocyte-derived macrophages --- non-cytopathic BVDV --- Australia --- deer --- prevalence --- ruminants --- serosurveillance --- wildlife disease --- diarrhea --- bovine respiratory disease --- milk production --- somatic cells count (SCC) --- reproductive performance --- BVDV persistent infection --- fetus --- thymus --- immune response --- flavivirus --- reverse genetics --- single round infectious particle --- bovine viral diarrhea virus (BVDV) --- escape mutant --- ERNS --- adaptation --- CRISPR --- knockout --- MDBK --- cell entry --- pestiviruses --- congenital tremor type A-II --- persistent infection --- rangeland beef herds --- northern Australia --- atypical porcine pestivirus (APPV) --- viral persistence --- congenital tremor --- swine --- asymptomatic --- genomic sequence --- purifying selection --- bovine pestiviruses --- bovine viral diarrhoea --- vaccination --- control --- diagnosis --- antigenic cross-reactivity --- Linda virus --- serological profile --- virus neutralization assay --- virus pathogenicity --- humoral immune response --- pestivirus --- pig --- APPV --- phylogenetic analysis --- Italy --- bvdv --- epidemiology --- reindeer --- border disease virus --- Norway --- Pestivirus --- BVDV --- CD46 --- life cell imaging --- attachment --- surface transport --- experimental infection --- natural infection --- pigs --- bovine viral diarrhoea virus --- persistent testicular infection --- prolonged testicular infection --- bovine --- testes --- semen --- wild boar --- ML tree --- Clade --- Bungowannah virus --- pestivirus F --- ruminant infection --- foetus --- porcine --- real-time PCR --- serology --- virology --- bovine viral diarrhea virus --- cytopathic BVDV --- immunosuppression --- lymphocyte apoptosis --- monocyte-derived macrophages --- non-cytopathic BVDV --- Australia --- deer --- prevalence --- ruminants --- serosurveillance --- wildlife disease --- diarrhea --- bovine respiratory disease --- milk production --- somatic cells count (SCC) --- reproductive performance --- BVDV persistent infection --- fetus --- thymus --- immune response --- flavivirus --- reverse genetics --- single round infectious particle --- bovine viral diarrhea virus (BVDV) --- escape mutant --- ERNS --- adaptation --- CRISPR --- knockout --- MDBK --- cell entry --- pestiviruses --- congenital tremor type A-II --- persistent infection --- rangeland beef herds --- northern Australia --- atypical porcine pestivirus (APPV) --- viral persistence --- congenital tremor --- swine --- asymptomatic --- genomic sequence --- purifying selection --- bovine pestiviruses --- bovine viral diarrhoea --- vaccination --- control --- diagnosis --- antigenic cross-reactivity