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Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and bas

Bone diseases in children. --- Children --- Diseases. --- Childhood diseases --- Children's diseases --- Diseases of children --- Juvenile diseases --- Pediatrics --- Pediatric bone diseases --- Pediatric bone disorders --- Bones --- Pediatric orthopedics --- Diseases

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Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, anti-resorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Bone diseases in children --- Drugs --- Pediatric pharmacology. --- Treatment. --- Effectiveness. --- Children --- Pharmacology --- Drug effectiveness --- Drug efficacy --- Effectiveness of drugs --- Efficacy of drugs --- Pediatric bone diseases --- Pediatric bone disorders --- Bones --- Pediatric orthopedics --- Drug effects --- Effect of drugs on --- Efficacy --- Physiological effect --- Diseases --- Endocrinology. --- Orthopedics. --- Pediatrics. --- Paediatrics --- Pediatric medicine --- Medicine --- Orthopaedics --- Orthopedia --- Surgery --- Internal medicine --- Hormones --- Health and hygiene --- Endocrinology .

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This book documents all the ways a growth plate can be damaged, other than fracture. This damage can be inflicted by a wide variety of insults, most of which are uncommon occurrences. They all, however, have two similar characteristics: normal roentgenographs at the time of insult and premature complete or partial arrest noted weeks, months, or years later. Because of this delay, the arrest is often not suspected or recognised early. The resulting bone deformity and relative shortening usually go undetected until corrective surgery is needed. This book emphasises etiology, diagnosis, and treatment of these injuries.

Pediatric orthopedics. --- Bone diseases in children. --- Pediatric bone diseases --- Pediatric bone disorders --- Pediatric orthopedia --- Medicine. --- Radiology. --- Orthopedics. --- Pediatrics. --- Medicine & Public Health. --- Imaging / Radiology. --- Bones --- Children --- Pediatric orthopedics --- Orthopedics --- Pediatrics --- Bone diseases in children --- Diseases --- Surgery --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Paediatrics --- Pediatric medicine --- Medicine --- Orthopaedics --- Orthopedia --- Health and hygiene --- Radiological physics --- Physics --- Radiation

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The book is an organized approach to understanding bone growth and disease. It integrates anatomic and radiologic knowledge of enchondral and membranous bone growth and emphasizes the similarities of the physis and acrophysis in development. While mainly written for trainees in radiology, pediatrics, and orthopedics, it will also be useful to practitioners in these fields. The artwork, jointly produced by artist and author, illustrates the concepts being promulgated. The identification of abnormality is aided by the explanations of the causes in terms of pattern recognition.

Medicine & Public Health. --- Imaging / Radiology. --- Diagnostic Radiology. --- Orthopedics. --- Pediatrics. --- Metabolic Diseases. --- Pediatric Surgery. --- Medicine. --- Medical radiology --- Metabolic diseases. --- Surgery. --- Médecine --- Radiologie médicale --- Orthopédie --- Pédiatrie --- Chirurgie --- Geraamte --- Kindergeneeskunde --- Bone development. --- Bone diseases in children. --- Bones -- Growth. --- Age Groups --- Musculoskeletal Development --- Skeleton --- Musculoskeletal Diseases --- Connective Tissue --- Persons --- Organogenesis --- Musculoskeletal System --- Tissues --- Diseases --- Musculoskeletal Physiological Processes --- Musculoskeletal Physiological Phenomena --- Anatomy --- Named Groups --- Embryonic and Fetal Development --- Musculoskeletal and Neural Physiological Phenomena --- Morphogenesis --- Growth and Development --- Phenomena and Processes --- Physiological Processes --- Physiological Phenomena --- Bone and Bones --- Bone Development --- Infant --- Adolescent --- Child --- Bone Diseases --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Physiology --- Bones --- Growth. --- Pediatric bone diseases --- Pediatric bone disorders --- Bone --- Bone development --- Bone growth --- Osteogenesis --- Growth --- Radiology. --- Pediatric surgery. --- Children --- Pediatric orthopedics --- Radiology, Medical. --- Surgery, Primitive --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Paediatrics --- Pediatric medicine --- Orthopaedics --- Orthopedia --- Surgery --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Health and hygiene --- Pediatric surgery --- Surgery, Pediatric --- Radiological physics --- Physics --- Radiation --- Treatment

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In the first contribution, Morbiducci and co-workers discuss the theoretical and methodological bases supporting the Lagrangian- and Euler-based methods, highlighting their application to cardiovascular flows. The second contribution, by the Ansón and van Lenthe groups, proposes an automated virtual bench test for evaluating the stability of custom shoulder implants without the necessity of mechanical testing. Urdeitx and Doweidar, in the third paper, also adopt the finite element method for developing a computational model aim to study cardiac cell behavior under mechano-electric stimulation. In the fourth contribution, Ayensa-Jiménez et al. develop a methodology to approximate the multidimensional probability density function of the parametric analysis obtained developing a mathematical model of the cancer evolution. The fifth paper is oriented to the topological data analysis; the group of Cueto and Chinesta designs a predictive model capable of estimating the state of drivers using the data collected from motion sensors. In the sixth contribution, the Ohayon and Finet group uses wall shear stress-derived descriptors to study the role of recirculation in the arterial restenosis due to different malapposed and overlapping stent conditions. In the seventh contribution, the research group of Antón demonstrates that the simulation time can be reduced for cardiovascular numerical analysis considering an adequate geometry-reduction strategy applicable to truncated patient specific artery. In the eighth paper, Grasa and Calvo present a numerical model based on the finite element method for simulating extraocular muscle dynamics. The ninth paper, authored by Kahla et al., presents a mathematical mechano-pharmaco-biological model for bone remodeling. Martínez, Peña, and co-workers propose in the tenth paper a methodology to calibrate the dissection properties of aorta layer, with the aim of providing useful information for reliable numerical tools. In the eleventh contribution, Martínez-Bocanegra et al. present the structural behavior of a foot model using a detailed finite element model. The twelfth contribution is centered on the methodology to perform a finite, element-based, numerical model of a hydroxyapatite 3D printed bone scaffold. In the thirteenth paper, Talygin and Gorodkov present analytical expressions describing swirling jets for cardiovascular applications. In the fourteenth contribution, Schenkel and Halliday propose a novel non-Newtonian particle transport model for red blood cells. Finally, Zurita et al. propose a parametric numerical tool for analyzing a silicone customized 3D printable trachea-bronchial prosthesis.

Technology: general issues --- finite element analysis --- shoulder implant stability --- implant design --- reverse shoulder arthroplasty --- micromotion --- in-silico --- 3D model --- cardiac cell --- cardiac muscle tissue --- cardiomyocyte --- electrical stimulation --- copulas --- design of experiments --- glioblastoma multiforme --- mathematical modelling --- Morse theory --- topological data analysis --- machine learning --- time series --- smart driving --- fixed points --- manifolds --- divergence --- hemodynamics --- computational fluid dynamics --- overlap --- malapposition --- stent --- stenosis --- thrombosis --- radioembolization --- liver cancer --- hepatic artery --- computational cost analysis --- personalized medicine --- patient specific --- finite element method --- implicit FEM --- explicit FEM --- skeletal muscle --- biomechanics --- mathematical model --- cell dynamics --- bone physiology --- bone disorders --- aortic dissection --- delamination tests --- cohesive zone model --- porcine aorta --- vascular mechanics --- foot finite element method --- foot and ankle model --- shared nodes --- separated mesh --- plantar pressure --- finite element modelling --- bone tissue engineering --- 3D scaffold --- additive manufacturing --- potential swirling flow --- Navier–Stokes equations --- unsteady swirling flow --- tornado-like jets --- haemorheology --- blood flow modelling --- particle transport --- numerical fluid mechanics --- tracheobronchial stent --- parametric model --- 3D printing --- customized prosthesis