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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
n/a --- biomaterial --- redifferentiation --- regenerative medicine --- skeletal muscle regeneration --- furcation defects --- Platelet-Rich Plasma (PRP) --- PRP --- fracture --- fibrin sealant --- periodontal surgery --- bone regeneration --- serum derived from plasma rich in growth factors (s-PRGF) --- cartilage repair --- myofibroblasts --- autologous platelet concentrates --- burns --- satellite cells --- articular cartilage --- stem cell niche --- wound healing --- quantification --- growth factors --- biologics --- platelet rich plasma --- meniscus --- adipose tissue --- Carprofen --- platelet-rich fibrin --- platelets --- hyperacute serum --- bone defects --- serum eye drops --- corneal epithelial defect --- fibrosis --- dog --- myoblasts --- differentiation --- chronic meniscal lesion --- horizontal meniscal tear --- PRGF --- collagen hydrogels --- periodontal defects --- bone grafting material --- composition --- cell therapy --- bone healing --- tissue healing --- trephination --- plasma rich plasma (PRP) --- bone repair --- plasma rich in growth factors --- knee arthrosis --- meniscus tear --- cornea regeneration --- wrist osteoarthritis --- periosteal sheet --- Platelet-Poor Plasma (PPP) --- platelet-rich plasma --- microfat --- bone grafting --- hyaluronic acid (NaHA) --- periodontal regeneration --- meniscus repair --- photobiomodulation therapy --- growth --- myogenesis --- blood derived products --- low-level laser therapy
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This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
Medicine --- bone --- collagen type I --- alginate --- conditioned medium --- viability --- MSC --- osteogenesis --- pulsed electromagnetic field --- osteogenic factors --- wool keratin scaffolds --- bone tissue engineering --- biocompatibility --- biomaterials --- bone augmentation --- bone conduction --- bone grafting --- calcium hydroxyapatite --- tissue regeneration --- dental implants --- osseointegration --- osteoporosis --- zoledronate --- animal model --- titanium membrane --- titanium foil --- occlusive titanium barrier --- guided bone regeneration --- osteoporotic condition --- xenograft --- bone regeneration --- titanium implants --- additive manufacturing --- reused powder --- unit cell topology --- tissue engineering --- mechanical properties --- stem cells --- surface functionalization --- titanium --- protein adsorption --- surface modifications --- cell interactions --- collagen hydrogel --- cell delivery --- olfactory ectomesenchyme stem cells --- bioactive glasses --- alkali-free --- sol–gel --- bone remodeling --- bone disorders --- biomechanics --- scaffolds --- microenvironment --- 3D bioprinting --- computational modeling --- bone implant --- bone defects --- chitosan --- degree of deacetylation --- bone formation --- X-ray micro CT --- histology --- sheep tibia
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In the past, osseointegration was regarded to be a mode of implant anchorage that simulated a simple wound healing phenomenon. Today, we have evidence that osseointegration is, in fact, a foreign body reaction that involves an immunologically derived bony demarcation of an implant to shield it off from the tissues. Marginal bone resorption around an oral implant cannot be properly understood without realizing the foreign body nature of the implant itself. Whereas the immunological response as such is positive for implant longevity, adverse immunological reactions may cause marginal bone loss in combination with combined factors. Combined factors include the hardware, clinical handling as well as patient characteristics that, even if each one of these factors only produce subliminal trauma, when acting together they may result in loss of marginal bone. The role of bacteria in the process of marginal bone loss is smaller than previously believed due to combined defense mechanisms of inflammation and immunological reactions, but if the defense is failing we may see bacterially induced marginal bone loss as well. However, problems with loss of marginal bone threatening implant survival remains relatively uncommon; we have today 10 years of clinical documentation of five different types of implant displaying a failure rate in the range of only 1 to 4 %.
Medicine --- osseointegration --- dental implant --- peri-implantitis --- ligature-induced peri-implantitis --- aseptic loosening --- systematic review --- immune system --- biomaterials --- foreign body reaction --- in vivo study --- oral implants --- marginal bone loss --- immunomodulation --- mechanotransduction --- Crestal bone loss --- osseosufficiency --- osseoseparation --- photoacoustic ultrasound --- brain–bone axis --- overloading --- radiography --- CBCT (cone beam computerized tomography) --- osteogenesis --- osteotomy --- bone healing --- bone chips --- drilling tool design --- fused deposition modeling --- polyether ether ketone --- biocomposite --- orthopedic implant --- oral implant --- mechanical properties --- wettability --- topography --- biocompatibility --- cell adhesion --- peri-implant endosseous healing --- dental implantation --- alveolar bone loss --- alveolar bone remodeling/regeneration --- bone biology --- finite element analysis (FEA) --- biomechanics --- cell plasticity --- dental implants --- electron microscopy --- scanning transmission electron microscopy --- bone-implant interface --- bone loss --- overdenture --- implant survival --- implant surface --- soft tissue --- split-mouth design --- oral health-related quality of life --- patient-reported outcome measures --- biomaterial --- bone --- immune --- implant --- healing --- titanium --- PEEK --- Cu --- micro-RNA --- microarray --- predictive biomarker --- epigenomics --- mucositis --- diagnosis --- over-treatment --- iatrogenic damage --- abutment height --- subcrestal implants --- implant insertion depth --- vertical mucosal thickness --- biological width --- implant installation --- anchorage technique --- histology --- intraosseous temperature --- finite element model --- ligature induced peri-implantitis --- arthroplasty --- replacement --- hip --- hypersensitivity --- contact --- allergy and immunology --- cytokines --- Interleukin-8 --- surface properties --- materials testing --- implant contamination --- scanning electron microscopy --- energy-dispersive X-ray spectrometry --- convergence --- clinical study --- biofilm --- infection --- perio-prosthetic joint infection --- periimplantitis --- electrolytic cleaning --- n/a --- zirconia --- insertion --- bone–implant interface --- heat --- bone damage --- early loss --- augmentation --- air flow --- re-osseointegration --- classification of bone defects --- dog study --- brain-bone axis
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Most of the treatments in medicine are patient specific, aren’t they? So why should we bother with individualizing implants if we adapt our therapy to patients anyway? Looking at the neighboring field of oncologic treatment, you would not question the fact that individualization of tumor therapy with personalized antibodies has led to the thriving of this field in terms of success in patient survival and positive responses to alternatives for conventional treatments. Regarding the latest cutting-edge developments in orthopedic surgery and biotechnology, including new imaging techniques and 3D-printing of bone substitutes as well as implants, we do have an armamentarium available to stimulate the race for innovation in medicine. This Special Issue of Journal of Personalized Medicine will gather all relevant new and developed techniques already in clinical practice. Examples include the developments in revision arthroplasty and tumor (pelvic replacement) surgery to recreate individual defects, individualized implants for primary arthroplasty to establish physiological joint kinematics, and personalized implants in fracture treatment, to name but a few.
Medicine --- patient specific implant --- custom made implant --- revision hip --- Paprosky --- pelvic discontinuity --- highly cancellous --- implant surface --- tibia --- titanium alloy --- 3D printing --- megaendoprosthesis --- orthopedic oncology --- limb salvage --- patient safety management --- vascular bypass --- soft tissue sarcoma --- vascular reconstruction --- shoulder arthroplasty --- X-ray images --- implant classification --- deep learning --- dense residual ensemble-network --- rotational invariant augmentation --- Three-Dimensional Printing (3DP) --- custom implant --- patient-specific implants (PSI) --- spinal surgery --- total knee replacement --- total knee arthroplasty --- kinematic alignment --- slope --- rotation --- navigation-assisted surgery --- tumor orthopedics --- oncologic orthopedics --- patient specific --- tumor surgery --- bone defects --- hip detection --- deep convolutional neural network --- radiography --- leg alignment --- patient-specific instruments --- custom-made implant --- rotational correction --- custom-made --- rTKA --- 3D-printed --- individual --- limb-salvage --- cone --- customised --- personalised --- knee replacement --- native knee morphology --- femoral J-Curve --- principal component analysis --- geometric parameter analysis --- individualized alignment --- restricted kinematic alignment --- robotic-assisted TKA --- MAKO --- safe zone --- pelvic tumors --- 3D printed prostheses --- computer aided design pelvic reconstruction --- arthroplasty --- complications --- bone tumor --- pelvis --- patient-specific --- individualized --- 3D-printing --- unicondylar knee arthroplasty --- unicompartmental knee replacement --- unicondylar knee replacement --- partial knee arthroplasty --- partial knee replacement --- UKA --- UKR --- augmented reality --- image-guided surgery --- intraoperative imaging --- simulation --- mixed reality --- reversed shoulder arthroplasty --- 3D planning --- total hip arthroplasty --- finite element method --- cemented and uncemented acetabular fixation --- polyethylene wear patterns --- cervical–diaphyseal angle --- center of rotation --- material head --- size head --- liner thickness --- preoperative planning --- patient-specific THA --- target zone --- leg length discrepancy --- range of motion --- edge loading --- TKA --- tricompartmental knee osteoarthritis --- iTotal --- n/a --- cervical-diaphyseal angle
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In the past, osseointegration was regarded to be a mode of implant anchorage that simulated a simple wound healing phenomenon. Today, we have evidence that osseointegration is, in fact, a foreign body reaction that involves an immunologically derived bony demarcation of an implant to shield it off from the tissues. Marginal bone resorption around an oral implant cannot be properly understood without realizing the foreign body nature of the implant itself. Whereas the immunological response as such is positive for implant longevity, adverse immunological reactions may cause marginal bone loss in combination with combined factors. Combined factors include the hardware, clinical handling as well as patient characteristics that, even if each one of these factors only produce subliminal trauma, when acting together they may result in loss of marginal bone. The role of bacteria in the process of marginal bone loss is smaller than previously believed due to combined defense mechanisms of inflammation and immunological reactions, but if the defense is failing we may see bacterially induced marginal bone loss as well. However, problems with loss of marginal bone threatening implant survival remains relatively uncommon; we have today 10 years of clinical documentation of five different types of implant displaying a failure rate in the range of only 1 to 4 %.
osseointegration --- dental implant --- peri-implantitis --- ligature-induced peri-implantitis --- aseptic loosening --- systematic review --- immune system --- biomaterials --- foreign body reaction --- in vivo study --- oral implants --- marginal bone loss --- immunomodulation --- mechanotransduction --- Crestal bone loss --- osseosufficiency --- osseoseparation --- photoacoustic ultrasound --- brain–bone axis --- overloading --- radiography --- CBCT (cone beam computerized tomography) --- osteogenesis --- osteotomy --- bone healing --- bone chips --- drilling tool design --- fused deposition modeling --- polyether ether ketone --- biocomposite --- orthopedic implant --- oral implant --- mechanical properties --- wettability --- topography --- biocompatibility --- cell adhesion --- peri-implant endosseous healing --- dental implantation --- alveolar bone loss --- alveolar bone remodeling/regeneration --- bone biology --- finite element analysis (FEA) --- biomechanics --- cell plasticity --- dental implants --- electron microscopy --- scanning transmission electron microscopy --- bone-implant interface --- bone loss --- overdenture --- implant survival --- implant surface --- soft tissue --- split-mouth design --- oral health-related quality of life --- patient-reported outcome measures --- biomaterial --- bone --- immune --- implant --- healing --- titanium --- PEEK --- Cu --- micro-RNA --- microarray --- predictive biomarker --- epigenomics --- mucositis --- diagnosis --- over-treatment --- iatrogenic damage --- abutment height --- subcrestal implants --- implant insertion depth --- vertical mucosal thickness --- biological width --- implant installation --- anchorage technique --- histology --- intraosseous temperature --- finite element model --- ligature induced peri-implantitis --- arthroplasty --- replacement --- hip --- hypersensitivity --- contact --- allergy and immunology --- cytokines --- Interleukin-8 --- surface properties --- materials testing --- implant contamination --- scanning electron microscopy --- energy-dispersive X-ray spectrometry --- convergence --- clinical study --- biofilm --- infection --- perio-prosthetic joint infection --- periimplantitis --- electrolytic cleaning --- n/a --- zirconia --- insertion --- bone–implant interface --- heat --- bone damage --- early loss --- augmentation --- air flow --- re-osseointegration --- classification of bone defects --- dog study --- brain-bone axis
Choose an application
Most of the treatments in medicine are patient specific, aren’t they? So why should we bother with individualizing implants if we adapt our therapy to patients anyway? Looking at the neighboring field of oncologic treatment, you would not question the fact that individualization of tumor therapy with personalized antibodies has led to the thriving of this field in terms of success in patient survival and positive responses to alternatives for conventional treatments. Regarding the latest cutting-edge developments in orthopedic surgery and biotechnology, including new imaging techniques and 3D-printing of bone substitutes as well as implants, we do have an armamentarium available to stimulate the race for innovation in medicine. This Special Issue of Journal of Personalized Medicine will gather all relevant new and developed techniques already in clinical practice. Examples include the developments in revision arthroplasty and tumor (pelvic replacement) surgery to recreate individual defects, individualized implants for primary arthroplasty to establish physiological joint kinematics, and personalized implants in fracture treatment, to name but a few.
patient specific implant --- custom made implant --- revision hip --- Paprosky --- pelvic discontinuity --- highly cancellous --- implant surface --- tibia --- titanium alloy --- 3D printing --- megaendoprosthesis --- orthopedic oncology --- limb salvage --- patient safety management --- vascular bypass --- soft tissue sarcoma --- vascular reconstruction --- shoulder arthroplasty --- X-ray images --- implant classification --- deep learning --- dense residual ensemble-network --- rotational invariant augmentation --- Three-Dimensional Printing (3DP) --- custom implant --- patient-specific implants (PSI) --- spinal surgery --- total knee replacement --- total knee arthroplasty --- kinematic alignment --- slope --- rotation --- navigation-assisted surgery --- tumor orthopedics --- oncologic orthopedics --- patient specific --- tumor surgery --- bone defects --- hip detection --- deep convolutional neural network --- radiography --- leg alignment --- patient-specific instruments --- custom-made implant --- rotational correction --- custom-made --- rTKA --- 3D-printed --- individual --- limb-salvage --- cone --- customised --- personalised --- knee replacement --- native knee morphology --- femoral J-Curve --- principal component analysis --- geometric parameter analysis --- individualized alignment --- restricted kinematic alignment --- robotic-assisted TKA --- MAKO --- safe zone --- pelvic tumors --- 3D printed prostheses --- computer aided design pelvic reconstruction --- arthroplasty --- complications --- bone tumor --- pelvis --- patient-specific --- individualized --- 3D-printing --- unicondylar knee arthroplasty --- unicompartmental knee replacement --- unicondylar knee replacement --- partial knee arthroplasty --- partial knee replacement --- UKA --- UKR --- augmented reality --- image-guided surgery --- intraoperative imaging --- simulation --- mixed reality --- reversed shoulder arthroplasty --- 3D planning --- total hip arthroplasty --- finite element method --- cemented and uncemented acetabular fixation --- polyethylene wear patterns --- cervical–diaphyseal angle --- center of rotation --- material head --- size head --- liner thickness --- preoperative planning --- patient-specific THA --- target zone --- leg length discrepancy --- range of motion --- edge loading --- TKA --- tricompartmental knee osteoarthritis --- iTotal --- n/a --- cervical-diaphyseal angle
Choose an application
In the past, osseointegration was regarded to be a mode of implant anchorage that simulated a simple wound healing phenomenon. Today, we have evidence that osseointegration is, in fact, a foreign body reaction that involves an immunologically derived bony demarcation of an implant to shield it off from the tissues. Marginal bone resorption around an oral implant cannot be properly understood without realizing the foreign body nature of the implant itself. Whereas the immunological response as such is positive for implant longevity, adverse immunological reactions may cause marginal bone loss in combination with combined factors. Combined factors include the hardware, clinical handling as well as patient characteristics that, even if each one of these factors only produce subliminal trauma, when acting together they may result in loss of marginal bone. The role of bacteria in the process of marginal bone loss is smaller than previously believed due to combined defense mechanisms of inflammation and immunological reactions, but if the defense is failing we may see bacterially induced marginal bone loss as well. However, problems with loss of marginal bone threatening implant survival remains relatively uncommon; we have today 10 years of clinical documentation of five different types of implant displaying a failure rate in the range of only 1 to 4 %.
Medicine --- osseointegration --- dental implant --- peri-implantitis --- ligature-induced peri-implantitis --- aseptic loosening --- systematic review --- immune system --- biomaterials --- foreign body reaction --- in vivo study --- oral implants --- marginal bone loss --- immunomodulation --- mechanotransduction --- Crestal bone loss --- osseosufficiency --- osseoseparation --- photoacoustic ultrasound --- brain-bone axis --- overloading --- radiography --- CBCT (cone beam computerized tomography) --- osteogenesis --- osteotomy --- bone healing --- bone chips --- drilling tool design --- fused deposition modeling --- polyether ether ketone --- biocomposite --- orthopedic implant --- oral implant --- mechanical properties --- wettability --- topography --- biocompatibility --- cell adhesion --- peri-implant endosseous healing --- dental implantation --- alveolar bone loss --- alveolar bone remodeling/regeneration --- bone biology --- finite element analysis (FEA) --- biomechanics --- cell plasticity --- dental implants --- electron microscopy --- scanning transmission electron microscopy --- bone-implant interface --- bone loss --- overdenture --- implant survival --- implant surface --- soft tissue --- split-mouth design --- oral health-related quality of life --- patient-reported outcome measures --- biomaterial --- bone --- immune --- implant --- healing --- titanium --- PEEK --- Cu --- micro-RNA --- microarray --- predictive biomarker --- epigenomics --- mucositis --- diagnosis --- over-treatment --- iatrogenic damage --- abutment height --- subcrestal implants --- implant insertion depth --- vertical mucosal thickness --- biological width --- implant installation --- anchorage technique --- histology --- intraosseous temperature --- finite element model --- ligature induced peri-implantitis --- arthroplasty --- replacement --- hip --- hypersensitivity --- contact --- allergy and immunology --- cytokines --- Interleukin-8 --- surface properties --- materials testing --- implant contamination --- scanning electron microscopy --- energy-dispersive X-ray spectrometry --- convergence --- clinical study --- biofilm --- infection --- perio-prosthetic joint infection --- periimplantitis --- electrolytic cleaning --- zirconia --- insertion --- bone-implant interface --- heat --- bone damage --- early loss --- augmentation --- air flow --- re-osseointegration --- classification of bone defects --- dog study --- osseointegration --- dental implant --- peri-implantitis --- ligature-induced peri-implantitis --- aseptic loosening --- systematic review --- immune system --- biomaterials --- foreign body reaction --- in vivo study --- oral implants --- marginal bone loss --- immunomodulation --- mechanotransduction --- Crestal bone loss --- osseosufficiency --- osseoseparation --- photoacoustic ultrasound --- brain-bone axis --- overloading --- radiography --- CBCT (cone beam computerized tomography) --- osteogenesis --- osteotomy --- bone healing --- bone chips --- drilling tool design --- fused deposition modeling --- polyether ether ketone --- biocomposite --- orthopedic implant --- oral implant --- mechanical properties --- wettability --- topography --- biocompatibility --- cell adhesion --- peri-implant endosseous healing --- dental implantation --- alveolar bone loss --- alveolar bone remodeling/regeneration --- bone biology --- finite element analysis (FEA) --- biomechanics --- cell plasticity --- dental implants --- electron microscopy --- scanning transmission electron microscopy --- bone-implant interface --- bone loss --- overdenture --- implant survival --- implant surface --- soft tissue --- split-mouth design --- oral health-related quality of life --- patient-reported outcome measures --- biomaterial --- bone --- immune --- implant --- healing --- titanium --- PEEK --- Cu --- micro-RNA --- microarray --- predictive biomarker --- epigenomics --- mucositis --- diagnosis --- over-treatment --- iatrogenic damage --- abutment height --- subcrestal implants --- implant insertion depth --- vertical mucosal thickness --- biological width --- implant installation --- anchorage technique --- histology --- intraosseous temperature --- finite element model --- ligature induced peri-implantitis --- arthroplasty --- replacement --- hip --- hypersensitivity --- contact --- allergy and immunology --- cytokines --- Interleukin-8 --- surface properties --- materials testing --- implant contamination --- scanning electron microscopy --- energy-dispersive X-ray spectrometry --- convergence --- clinical study --- biofilm --- infection --- perio-prosthetic joint infection --- periimplantitis --- electrolytic cleaning --- zirconia --- insertion --- bone-implant interface --- heat --- bone damage --- early loss --- augmentation --- air flow --- re-osseointegration --- classification of bone defects --- dog study
Choose an application
Most of the treatments in medicine are patient specific, aren’t they? So why should we bother with individualizing implants if we adapt our therapy to patients anyway? Looking at the neighboring field of oncologic treatment, you would not question the fact that individualization of tumor therapy with personalized antibodies has led to the thriving of this field in terms of success in patient survival and positive responses to alternatives for conventional treatments. Regarding the latest cutting-edge developments in orthopedic surgery and biotechnology, including new imaging techniques and 3D-printing of bone substitutes as well as implants, we do have an armamentarium available to stimulate the race for innovation in medicine. This Special Issue of Journal of Personalized Medicine will gather all relevant new and developed techniques already in clinical practice. Examples include the developments in revision arthroplasty and tumor (pelvic replacement) surgery to recreate individual defects, individualized implants for primary arthroplasty to establish physiological joint kinematics, and personalized implants in fracture treatment, to name but a few.
Medicine --- patient specific implant --- custom made implant --- revision hip --- Paprosky --- pelvic discontinuity --- highly cancellous --- implant surface --- tibia --- titanium alloy --- 3D printing --- megaendoprosthesis --- orthopedic oncology --- limb salvage --- patient safety management --- vascular bypass --- soft tissue sarcoma --- vascular reconstruction --- shoulder arthroplasty --- X-ray images --- implant classification --- deep learning --- dense residual ensemble-network --- rotational invariant augmentation --- Three-Dimensional Printing (3DP) --- custom implant --- patient-specific implants (PSI) --- spinal surgery --- total knee replacement --- total knee arthroplasty --- kinematic alignment --- slope --- rotation --- navigation-assisted surgery --- tumor orthopedics --- oncologic orthopedics --- patient specific --- tumor surgery --- bone defects --- hip detection --- deep convolutional neural network --- radiography --- leg alignment --- patient-specific instruments --- custom-made implant --- rotational correction --- custom-made --- rTKA --- 3D-printed --- individual --- limb-salvage --- cone --- customised --- personalised --- knee replacement --- native knee morphology --- femoral J-Curve --- principal component analysis --- geometric parameter analysis --- individualized alignment --- restricted kinematic alignment --- robotic-assisted TKA --- MAKO --- safe zone --- pelvic tumors --- 3D printed prostheses --- computer aided design pelvic reconstruction --- arthroplasty --- complications --- bone tumor --- pelvis --- patient-specific --- individualized --- 3D-printing --- unicondylar knee arthroplasty --- unicompartmental knee replacement --- unicondylar knee replacement --- partial knee arthroplasty --- partial knee replacement --- UKA --- UKR --- augmented reality --- image-guided surgery --- intraoperative imaging --- simulation --- mixed reality --- reversed shoulder arthroplasty --- 3D planning --- total hip arthroplasty --- finite element method --- cemented and uncemented acetabular fixation --- polyethylene wear patterns --- cervical-diaphyseal angle --- center of rotation --- material head --- size head --- liner thickness --- preoperative planning --- patient-specific THA --- target zone --- leg length discrepancy --- range of motion --- edge loading --- TKA --- tricompartmental knee osteoarthritis --- iTotal --- patient specific implant --- custom made implant --- revision hip --- Paprosky --- pelvic discontinuity --- highly cancellous --- implant surface --- tibia --- titanium alloy --- 3D printing --- megaendoprosthesis --- orthopedic oncology --- limb salvage --- patient safety management --- vascular bypass --- soft tissue sarcoma --- vascular reconstruction --- shoulder arthroplasty --- X-ray images --- implant classification --- deep learning --- dense residual ensemble-network --- rotational invariant augmentation --- Three-Dimensional Printing (3DP) --- custom implant --- patient-specific implants (PSI) --- spinal surgery --- total knee replacement --- total knee arthroplasty --- kinematic alignment --- slope --- rotation --- navigation-assisted surgery --- tumor orthopedics --- oncologic orthopedics --- patient specific --- tumor surgery --- bone defects --- hip detection --- deep convolutional neural network --- radiography --- leg alignment --- patient-specific instruments --- custom-made implant --- rotational correction --- custom-made --- rTKA --- 3D-printed --- individual --- limb-salvage --- cone --- customised --- personalised --- knee replacement --- native knee morphology --- femoral J-Curve --- principal component analysis --- geometric parameter analysis --- individualized alignment --- restricted kinematic alignment --- robotic-assisted TKA --- MAKO --- safe zone --- pelvic tumors --- 3D printed prostheses --- computer aided design pelvic reconstruction --- arthroplasty --- complications --- bone tumor --- pelvis --- patient-specific --- individualized --- 3D-printing --- unicondylar knee arthroplasty --- unicompartmental knee replacement --- unicondylar knee replacement --- partial knee arthroplasty --- partial knee replacement --- UKA --- UKR --- augmented reality --- image-guided surgery --- intraoperative imaging --- simulation --- mixed reality --- reversed shoulder arthroplasty --- 3D planning --- total hip arthroplasty --- finite element method --- cemented and uncemented acetabular fixation --- polyethylene wear patterns --- cervical-diaphyseal angle --- center of rotation --- material head --- size head --- liner thickness --- preoperative planning --- patient-specific THA --- target zone --- leg length discrepancy --- range of motion --- edge loading --- TKA --- tricompartmental knee osteoarthritis --- iTotal
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