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Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

Research & information: general --- Biology, life sciences --- Food & society --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- n/a