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Book
Molecular Research of Endometrial Pathophysiology
Authors: ---
ISBN: 3039214969 3039214950 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

endometrial stromal cells --- endometrial cell --- uterine cancer --- regeneration --- stem cell markers --- RANK --- chronic endometritis --- small RNA sequencing --- HOXA10 --- Vitamin D --- PPP2R1A --- molecular marker --- translational research --- angiogenesis --- endometriosis --- oestradiol --- mtDNA mutations --- antioxidant response --- protein phosphatase --- SMAP --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- estrogen dependent --- endometrial regeneration --- mesenchymal stem cells --- endometrial cancer --- niche --- gene expression --- phosphoinositide 3-kinase --- lncRNAs --- mitochondrial biogenesis --- inflammation --- preclinical studies --- miRNA --- orthoxenograft --- tight junction --- proliferation --- aromatase --- testosterone --- CRISPR/Cas9 --- endometrium --- developmental pathway --- PP2A --- avatar --- infertility --- prognosis --- gene editing --- kinase inhibitor --- implantation --- haploinsufficiency --- contrast-enhanced CT scan --- pathway --- dehydroepiandrosterone (DHEA) --- CTCF --- PIK3CB --- zinc finger --- ectopic stroma --- liquid biopsy --- type II endometrial carcinoma --- eutopic and ectopic endometrium --- preclinical models --- EDN1 --- uterine aspirate --- cell contacts --- tumour suppressor gene --- pathogenomics --- mitochondrial dynamics --- adult stem cells --- PIK3CA --- murine models --- menstrual cycle --- immunomodulation --- decidualisation --- breakdown --- bioluminescence imaging --- protein kinase --- macrophages --- adherens junction --- exosomes --- immunohistochemistry --- orthotopic xenograft model --- decidualization --- p110? --- deficit of complex I --- targeted therapy --- mesenchymal stem cell --- sulfatase --- TRP channels --- personalized medicine --- mitophagy --- miR-375 --- migration --- microRNA --- gap junction --- cancer --- LGR5 --- miR-139-5p


Book
A Meeting of Minds: In Recognition of the Contributions of Randall J. Cohrs
Authors: --- ---
ISBN: 303655260X 3036552596 Year: 2022 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

A Special Issue in memory of Randall J. Cohrs, Ph.D. Topics include original research reports on a variety of viruses as well as reviews and commentaries on Randy’s contributions to many investigations.

Keywords

Research & information: general --- Biology, life sciences --- varicella-zoster virus --- Oka strain --- human herpesvirus 6 --- human herpesvirus 7 --- corticosteroids --- serious adverse event --- herpes zoster --- IL-6 --- IL-10 --- innate immunity --- VLT --- VLT-ORF63 --- CRISPR/Cas9 --- BAC mutagenesis --- flavivirus --- SARS-CoV-2 --- pandemic preparedness --- host–virus interactions --- prion --- vaccines --- interferon lambda --- virus --- herpes simplex virus type 1 --- herpes simplex virus type 2 --- neonatal herpesvirus infection --- HSV UL6 --- herpesvirus encephalitis --- herpesvirus hepatitis --- acyclovir --- HerpeSelect test --- viral sequencing --- HELLP syndrome --- lipids --- dengue virus --- acyl-CoA --- acyl-CoA thioesterase --- fatty acids --- membranes --- rheostat --- fatty acyl-CoA --- Marek’s disease virus --- live-cell genome visualization --- lytic replication --- T cells --- latency --- genome integration --- TetO/TetR system --- varicella zoster virus --- reactivation --- genome cleavage --- AAV --- antiviral therapies --- HSV-1 --- cornea --- trigeminal ganglia --- interferon-γ --- interferon stimulatory genes --- TRIM21 --- HSV --- EBV --- KSHV --- MHV68 --- PIC --- transcription --- productive elongation --- mRNA --- rRNA --- tRNA --- herpes --- viral reactivation --- spaceflight --- dermatitis --- stress --- immune depression --- antiviral drugs --- bacterial artificial chromosome --- luciferase --- bioluminescence imaging --- skin organ culture --- humanized mice --- β-Coronavirus --- mouse hepatitis virus-A59/MHV-A59 --- mouse hepatitis virus-2/MHV2 spike protein --- fusion peptide/FP --- cell-to-cell fusion (fusogenicity) --- neuropathogenesis --- hepatitis --- demyelination --- structural rigidity --- simian varicella virus --- herpesvirus --- varicella --- VZV --- neuro-attenuated --- ORF7 --- vaccine --- n/a --- antiviral --- COVID-19 --- drug discovery --- coronavirus --- spike protein --- Mpro --- RdRp --- PLpro --- skin --- epidermis --- keratinocytes --- epidermal differentiation --- cutaneous blistering lesions --- keratins --- autophagy --- immunity --- human neuron culture --- non-coding RNA --- CD8 T cell --- T-cell epitope --- NK cell --- KIR3DL1 --- HLA-B*57:01 --- herpes simplex virus --- zoster --- skin pathogenesis --- HSV-2 --- neurons --- cell culture --- varicella-zoster --- gene expression --- ganglion --- autopsy --- saliva --- salivary VZV DNA --- dengue viruses --- Aedes aegypti --- adaptive mutation --- host-virus interactions --- Marek's disease virus

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