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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

marine microorganisms --- natural products --- structural elucidation --- biological activities --- structure-activity relationships

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Over 70% of the Earth’s surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.

Medicine --- co-culture --- marine microbes --- natural products --- structural diversity --- biological activities --- food allergy --- deep-sea-derived viridicatol --- X-ray single crystal --- intestinal barrier --- mast cell --- calcium influx --- Chlorella --- enzymes --- lipases --- molecular modeling --- sulfated polysaccharides --- antiviral --- SARS-CoV-2 --- docking --- molecular dynamic simulations --- sea cucumber --- bioactivity --- diversity --- microorganism --- polyketides --- alkaloids --- marine-derived fungus --- Penicillium sp. --- indole-diterpenoids --- cytotoxicity --- antibacterial activity --- Leizhou Peninsula --- mangrove soil --- actinomycetia --- antimicrobial activity --- secondary metabolites --- dereplication --- metabolomics tools --- trioxacarcins --- mansouramycins --- isoquinolinequinones --- marine-derived Streptomyces sp. --- n/a

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Over 70% of the Earth’s surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.

Medicine --- co-culture --- marine microbes --- natural products --- structural diversity --- biological activities --- food allergy --- deep-sea-derived viridicatol --- X-ray single crystal --- intestinal barrier --- mast cell --- calcium influx --- Chlorella --- enzymes --- lipases --- molecular modeling --- sulfated polysaccharides --- antiviral --- SARS-CoV-2 --- docking --- molecular dynamic simulations --- sea cucumber --- bioactivity --- diversity --- microorganism --- polyketides --- alkaloids --- marine-derived fungus --- Penicillium sp. --- indole-diterpenoids --- cytotoxicity --- antibacterial activity --- Leizhou Peninsula --- mangrove soil --- actinomycetia --- antimicrobial activity --- secondary metabolites --- dereplication --- metabolomics tools --- trioxacarcins --- mansouramycins --- isoquinolinequinones --- marine-derived Streptomyces sp.

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Brown algae comprise approx. 2040 species grown in various climatic conditions. They represent a reservoir of various bioactive compounds, including fucoidan, alginate, phlorotannins, and fucoxanthins. They have shown an array of applications in pharmaceutical and medical fields. Hence, the Guest Editor invites all interested authors to submit their contributions to the current issue in Marine Drugs entitled “Bioactive Compounds from Brown Algae”. It aims to highlight different aspects of bioactive compounds found in brown algae, in either research or review articles. Specifically, we are interested in downstream processes, chemistry, biotechnology, and applications of, for example, heteropolysaccharides and other brown algae bioactives. In addition, the structure elucidation and enzymatic modification of these components are also within the scope of the present Issue.

hepatic steatosis --- lipogenesis --- seaweed --- polyphenol --- fucoidans --- fucoidanases --- glycosidic linkages --- molecular masses --- NMR --- structure–activity relationships --- fucoidan --- cancer --- VEGF --- gene expression --- toxicity --- Dictyosiphon foeniculaceus --- retinal pigment epithelium --- glioblastoma --- astrocytes --- uveal melanoma --- 7-phloro-eckol --- HepG2/CYP2E1 cells --- oxidative stress --- apoptosis --- anti-lung cancer --- brown algae --- human lung carcinoma A-549 cells --- oversulfation --- Sargassum aquifolium --- phlorotannins --- antifungal --- larvicidal --- brown seaweeds --- biological activities --- anti-inflammatory --- antioxidant --- coastal area --- crude lipid extract --- Sargassum ilicifolium --- gut microbiota --- bioaccessibility --- short-chain fatty acids --- prebiotics --- gastrointestinal tract --- noise --- hearing loss --- dieckol --- PFF-A --- alginate --- laminarin --- bioactivity

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food --- drugs --- cosmetics --- traditional Chinese medicine --- public health --- biological activities --- Business, Economy and Management --- Economics --- Drugs --- Food adulteration and inspection --- Food --- Drug Evaluation. --- Food Analysis. --- Food Inspection. --- Levensmiddelen. --- Voeding. --- Geneesmiddelen. --- Chemische analyses. --- Food adulteration and inspection. --- Analysis --- analysis. --- Analysis. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Food Inspections --- Inspection, Food --- Inspections, Food --- Analysis, Food --- Analyses, Food --- Food Analyses --- Food Quality --- Drug Evaluation Studies --- Evaluation Studies, Drug --- Drug Evaluation Study --- Drug Evaluations --- Evaluation Study, Drug --- Evaluation, Drug --- Evaluations, Drug --- Studies, Drug Evaluation --- Study, Drug Evaluation --- Drugs, Investigational --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Drug Dosage Calculations --- analysis --- Pharmacology. Therapy --- Agriculture. Animal husbandry. Hunting. Fishery --- Analysis of food --- Chemistry of food --- Food, Chemistry of --- Chemistry, Technical --- Sanitary chemistry --- Food, Pure --- Inspection of food --- Pure food --- Adulterations --- Consumer protection --- Public health --- Pharmaceutical analysis --- Chemistry --- Composition --- Adulteration --- Inspection --- farmacologie --- traditional chinese medicine