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Acceptance or rejection of implanted biomaterials is strongly dependent on an appropriate bio-interface between the biomaterial and its surrounding tissue. Given the fact that most bulk materials only provide mechanical stability for the implant and may not interact with tissues and fluids in vivo, surface modification and engineering of biomaterials plays a significant role towards addressing major clinical unmet challenges. Increasing data showed that altering surface properties including physiochemical, topographical, and mechanical characteristics, is a promising approach to tackle these problems. Surface engineering of biomaterials could influence the subsequent tissue and cellular events such as protein adsorption, cellular recolonization, adhesion, proliferation, migration, and the inflammatory response. Moreover, it could be based on mimicking the complex cell structure and environment or hierarchical nature of the bone. In this case, the design of nano/micrometer patterns and morphologies with control over their properties has been receiving the attention of biomaterial scientists due to the promising results for the relevant biomedical applications. This Special Issue presents original research papers that report on the current state-of-the-art in surface engineering of biomaterials, particularly implants and biomedical devices.
Research & information: general --- surface modification --- micro-powder blasting --- aluminum anodization --- micro/nano-structure --- cell culture --- electrophoretic deposition --- enamel remineralization --- bioactive glass --- spectrophotometry --- nanoindentation --- rhBMP-2 --- rhPDGF-BB --- heparin --- implant surface --- osseointegration --- bone regeneration --- beagle dog --- diamond-like carbon --- frictional property --- hydrogen content --- sp2/sp3 ratio --- hydroxyapatite --- titanium implants --- mineralizing solution --- solution plasma treatment --- surface modification --- micro-powder blasting --- aluminum anodization --- micro/nano-structure --- cell culture --- electrophoretic deposition --- enamel remineralization --- bioactive glass --- spectrophotometry --- nanoindentation --- rhBMP-2 --- rhPDGF-BB --- heparin --- implant surface --- osseointegration --- bone regeneration --- beagle dog --- diamond-like carbon --- frictional property --- hydrogen content --- sp2/sp3 ratio --- hydroxyapatite --- titanium implants --- mineralizing solution --- solution plasma treatment
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Acceptance or rejection of implanted biomaterials is strongly dependent on an appropriate bio-interface between the biomaterial and its surrounding tissue. Given the fact that most bulk materials only provide mechanical stability for the implant and may not interact with tissues and fluids in vivo, surface modification and engineering of biomaterials plays a significant role towards addressing major clinical unmet challenges. Increasing data showed that altering surface properties including physiochemical, topographical, and mechanical characteristics, is a promising approach to tackle these problems. Surface engineering of biomaterials could influence the subsequent tissue and cellular events such as protein adsorption, cellular recolonization, adhesion, proliferation, migration, and the inflammatory response. Moreover, it could be based on mimicking the complex cell structure and environment or hierarchical nature of the bone. In this case, the design of nano/micrometer patterns and morphologies with control over their properties has been receiving the attention of biomaterial scientists due to the promising results for the relevant biomedical applications. This Special Issue presents original research papers that report on the current state-of-the-art in surface engineering of biomaterials, particularly implants and biomedical devices.
Research & information: general --- surface modification --- micro-powder blasting --- aluminum anodization --- micro/nano-structure --- cell culture --- electrophoretic deposition --- enamel remineralization --- bioactive glass --- spectrophotometry --- nanoindentation --- rhBMP-2 --- rhPDGF-BB --- heparin --- implant surface --- osseointegration --- bone regeneration --- beagle dog --- diamond-like carbon --- frictional property --- hydrogen content --- sp2/sp3 ratio --- hydroxyapatite --- titanium implants --- mineralizing solution --- solution plasma treatment
Choose an application
Acceptance or rejection of implanted biomaterials is strongly dependent on an appropriate bio-interface between the biomaterial and its surrounding tissue. Given the fact that most bulk materials only provide mechanical stability for the implant and may not interact with tissues and fluids in vivo, surface modification and engineering of biomaterials plays a significant role towards addressing major clinical unmet challenges. Increasing data showed that altering surface properties including physiochemical, topographical, and mechanical characteristics, is a promising approach to tackle these problems. Surface engineering of biomaterials could influence the subsequent tissue and cellular events such as protein adsorption, cellular recolonization, adhesion, proliferation, migration, and the inflammatory response. Moreover, it could be based on mimicking the complex cell structure and environment or hierarchical nature of the bone. In this case, the design of nano/micrometer patterns and morphologies with control over their properties has been receiving the attention of biomaterial scientists due to the promising results for the relevant biomedical applications. This Special Issue presents original research papers that report on the current state-of-the-art in surface engineering of biomaterials, particularly implants and biomedical devices.
surface modification --- micro-powder blasting --- aluminum anodization --- micro/nano-structure --- cell culture --- electrophoretic deposition --- enamel remineralization --- bioactive glass --- spectrophotometry --- nanoindentation --- rhBMP-2 --- rhPDGF-BB --- heparin --- implant surface --- osseointegration --- bone regeneration --- beagle dog --- diamond-like carbon --- frictional property --- hydrogen content --- sp2/sp3 ratio --- hydroxyapatite --- titanium implants --- mineralizing solution --- solution plasma treatment
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Knowledge, new concepts, and theoretical and experimental studies on coatings of implant and bone surfaces have been explained. Recent advancements in coating methods and materials for surface coating have both been extensively shown. Research on the use of modified implants and bone can be viewed through this paper. Improved understanding of the processes underpinning greater functionality will result from this issue.
Medicine --- curcumin --- high glucose --- osteogenesis --- bone formation --- diabetic osteoporosis --- cell survival --- cell migration assay --- calcium silicate-based cements --- calcium nodule formation --- bone substitute --- sinus floor augmentation --- maxillary tuberosity --- blood clotting --- dental implants --- hydrophilicity --- titanium --- ultraviolet rays --- bone morphogenetic protein 4 --- cell differentiation --- cellular spheroids --- gingiva osteogenesis --- stem cells --- titanium mesh --- bone graft --- guided bone regeneration --- ridge augmentation --- surface topography --- bacterial adhesion --- biomimetics --- soft lithography --- surface modification --- anti-bacterial agents --- calcium phosphate --- guided tissue regeneration --- membranes --- calcium sulfate --- dental implant --- sinus lift --- bioactive materials --- bioactive ceramic --- bioactive glass --- nanohydroxyapatite --- sol-gel process
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The book outlines a series of developments made in the manufacturing of bio-functional layers via Physical Vapour-Deposited (PVD) technologies for application in various areas of healthcare. The scrutinized PVD methods include Radio-Frequency Magnetron Sputtering (RF-MS), Cathodic Arc Evaporation, Pulsed Electron Deposition and its variants, Pulsed Laser Deposition, and Matrix-Assisted Pulsed Laser Evaporation (MAPLE) due to their great promise, especially in dentistry and orthopaedics. These methods have yet to gain traction for industrialization and large-scale application in biomedicine. A new generation of implant coatings can be made available by the (1) incorporation of organic moieties (e.g., proteins, peptides, enzymes) into thin films using innovative methods such as combinatorial MAPLE, (2) direct coupling of therapeutic agents with bioactive glasses or ceramics within substituted or composite layers via RF-MS, or (3) innovation in high-energy deposition methods, such as arc evaporation or pulsed electron beam methods.
Technology: general issues --- pulsed electron deposition --- thin films --- orthopedic applications --- bioactivity --- ceramic coatings --- yttria-stabilized zirconia --- calcium phosphates --- hydroxyapatite --- biomimetic coatings --- antibacterial coatings --- thin film --- RF magnetron sputtering --- pulsed DC --- Silicon --- bio-coatings --- biomimetics --- laser deposition --- PLD --- MAPLE --- tissue engineering --- cancer --- titanium-based carbonitrides --- coating --- corrosion resistance --- X-ray diffraction --- nanoindentation --- cathodic arc deposition --- biological-derived hydroxyapatite coatings --- lithium doping --- food industrial by-products --- in vivo extraction force --- pulsed laser deposition --- 3D printing --- calcium phosphate --- PEEK --- surface modification --- sputtering --- ToFSIMS --- XPS --- implant coating --- bioactive glass --- copper doping --- gallium doping --- mechanical --- cytocompatibility --- antibacterial --- physical vapour deposition --- thin-films --- medical devices --- biomimicry
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The book outlines a series of developments made in the manufacturing of bio-functional layers via Physical Vapour-Deposited (PVD) technologies for application in various areas of healthcare. The scrutinized PVD methods include Radio-Frequency Magnetron Sputtering (RF-MS), Cathodic Arc Evaporation, Pulsed Electron Deposition and its variants, Pulsed Laser Deposition, and Matrix-Assisted Pulsed Laser Evaporation (MAPLE) due to their great promise, especially in dentistry and orthopaedics. These methods have yet to gain traction for industrialization and large-scale application in biomedicine. A new generation of implant coatings can be made available by the (1) incorporation of organic moieties (e.g., proteins, peptides, enzymes) into thin films using innovative methods such as combinatorial MAPLE, (2) direct coupling of therapeutic agents with bioactive glasses or ceramics within substituted or composite layers via RF-MS, or (3) innovation in high-energy deposition methods, such as arc evaporation or pulsed electron beam methods.
pulsed electron deposition --- thin films --- orthopedic applications --- bioactivity --- ceramic coatings --- yttria-stabilized zirconia --- calcium phosphates --- hydroxyapatite --- biomimetic coatings --- antibacterial coatings --- thin film --- RF magnetron sputtering --- pulsed DC --- Silicon --- bio-coatings --- biomimetics --- laser deposition --- PLD --- MAPLE --- tissue engineering --- cancer --- titanium-based carbonitrides --- coating --- corrosion resistance --- X-ray diffraction --- nanoindentation --- cathodic arc deposition --- biological-derived hydroxyapatite coatings --- lithium doping --- food industrial by-products --- in vivo extraction force --- pulsed laser deposition --- 3D printing --- calcium phosphate --- PEEK --- surface modification --- sputtering --- ToFSIMS --- XPS --- implant coating --- bioactive glass --- copper doping --- gallium doping --- mechanical --- cytocompatibility --- antibacterial --- physical vapour deposition --- thin-films --- medical devices --- biomimicry
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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate–poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- n/a --- alginate-poloxamer copolymer
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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Technology: general issues --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate-poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate-poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory
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The book outlines a series of developments made in the manufacturing of bio-functional layers via Physical Vapour-Deposited (PVD) technologies for application in various areas of healthcare. The scrutinized PVD methods include Radio-Frequency Magnetron Sputtering (RF-MS), Cathodic Arc Evaporation, Pulsed Electron Deposition and its variants, Pulsed Laser Deposition, and Matrix-Assisted Pulsed Laser Evaporation (MAPLE) due to their great promise, especially in dentistry and orthopaedics. These methods have yet to gain traction for industrialization and large-scale application in biomedicine. A new generation of implant coatings can be made available by the (1) incorporation of organic moieties (e.g., proteins, peptides, enzymes) into thin films using innovative methods such as combinatorial MAPLE, (2) direct coupling of therapeutic agents with bioactive glasses or ceramics within substituted or composite layers via RF-MS, or (3) innovation in high-energy deposition methods, such as arc evaporation or pulsed electron beam methods.
Technology: general issues --- pulsed electron deposition --- thin films --- orthopedic applications --- bioactivity --- ceramic coatings --- yttria-stabilized zirconia --- calcium phosphates --- hydroxyapatite --- biomimetic coatings --- antibacterial coatings --- thin film --- RF magnetron sputtering --- pulsed DC --- Silicon --- bio-coatings --- biomimetics --- laser deposition --- PLD --- MAPLE --- tissue engineering --- cancer --- titanium-based carbonitrides --- coating --- corrosion resistance --- X-ray diffraction --- nanoindentation --- cathodic arc deposition --- biological-derived hydroxyapatite coatings --- lithium doping --- food industrial by-products --- in vivo extraction force --- pulsed laser deposition --- 3D printing --- calcium phosphate --- PEEK --- surface modification --- sputtering --- ToFSIMS --- XPS --- implant coating --- bioactive glass --- copper doping --- gallium doping --- mechanical --- cytocompatibility --- antibacterial --- physical vapour deposition --- thin-films --- medical devices --- biomimicry --- pulsed electron deposition --- thin films --- orthopedic applications --- bioactivity --- ceramic coatings --- yttria-stabilized zirconia --- calcium phosphates --- hydroxyapatite --- biomimetic coatings --- antibacterial coatings --- thin film --- RF magnetron sputtering --- pulsed DC --- Silicon --- bio-coatings --- biomimetics --- laser deposition --- PLD --- MAPLE --- tissue engineering --- cancer --- titanium-based carbonitrides --- coating --- corrosion resistance --- X-ray diffraction --- nanoindentation --- cathodic arc deposition --- biological-derived hydroxyapatite coatings --- lithium doping --- food industrial by-products --- in vivo extraction force --- pulsed laser deposition --- 3D printing --- calcium phosphate --- PEEK --- surface modification --- sputtering --- ToFSIMS --- XPS --- implant coating --- bioactive glass --- copper doping --- gallium doping --- mechanical --- cytocompatibility --- antibacterial --- physical vapour deposition --- thin-films --- medical devices --- biomimicry
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Advanced Glasses, Composites and Ceramics for High-Growth Industries (CoACH) was a European Training Network (ETN) project (http://www.coach-etn.eu/) funded by the Horizon 2020 program. CoACH involved multiple actors in the innovation ecosystem for advanced materials, composed of five universities and ten enterprises in seven different European countries. The project studied the next generation of materials that could bring innovation in the healthcare, construction, and energy sectors, among others, from new bioactive glasses for bone implants to eco-friendly cements and new environmentally friendly thermoelectrics for energy conversion. The novel materials developed in the CoACH project pave the way for innovative products, improved cost competitiveness, and positive environmental impact. The present Special Issue contains 14 papers resulting from the CoACH project, showcasing the breadth of materials and processes developed during the project.
shear strength --- chitosan --- inorganic gel casting --- glass–ceramic foams --- fly ash --- cellulose fibers --- antibacterial --- solid-liquid interdiffusion (SLID) bonding --- bioactive glass-ceramic --- seawater exposure --- Er3+ luminescence property --- wastes incorporation --- transient-liquid phase bonding (TLPB) --- cellulose modification --- biocompatibility --- glass–ceramic --- GeTe --- lowered zT --- accelerated testing --- elastic modulus --- PCL --- silver --- glass fiber-reinforced polymers --- oxidation resistance --- SOFC --- GFRPs --- high-temperature thermoelectric material --- joining --- waste glass --- diffusion --- hybrid-coating --- glass recycling --- phosphate glass --- dip coating --- graphitization --- geopolymer composite --- direct particle doping --- Thermoelectrics --- flexural biaxial test --- Ba-doping --- residual stresses --- silver-doped mesoporous glass --- ball-on-3-balls test --- glass foams --- Vicryl Plus suture --- DMA --- SOEC --- gravimetric --- skutterudite --- wood-derived biocarbon --- evanescent wave optical fiber sensors --- ageing --- oxyfluoride phosphate glass --- SOC --- PMCs --- fractography --- gel casting --- Zinc --- alkali activation --- mechanical strength --- coatings --- Al-doping --- polydopamine --- testing and aging --- loss of band convergence --- thermal conductivity --- Er2O3-doped particles
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