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After the long history of screening, it is becoming difficult to find novel compounds from microorganisms and plants anywhere in the world. Until now, more than about 30,000 marine natural products have been reported. However, with the development of marine natural products research, the hit rate of new compounds is also decreasing. Scientists are now turning their attention to the deep sea, where a high hit rate of novel compounds is expected. Many small compounds and peptides from microorganisms and sponges are with therapeutic activity are shown in this book. This Special Issue Book, “Natural Products from the Deep Sea”, should be useful for the screening of novel and useful compounds from nature.

Medicine --- deep sea marine-derived fungus --- Myrothecium sp. --- myrothecol --- nitric oxide (NO) --- antioxidant activity --- macrolactam --- Deep-Sea-Derived Streptomyces --- abiotic formation --- natural product --- antifungal activity --- Thorectandra choanoides --- tryptophan alkaloid --- indoleamine 2,3-dioxygenase --- aplysinopsins --- GNPS molecular network --- cellular signal transduction --- bioactive metabolite --- deep-sea organisms --- anti-inflammatory agent --- anticancer agent --- Mariana Trench --- Micromonospora provocatoris MT25 --- desferrioxamine --- n-acetylglutaminyl glutamine amide --- 1H-15N 2D-NMR --- genomics --- biosynthetic gene clusters --- stress genes --- crustins --- antibacterial peptides --- hydrothermal vent --- anti-Gram-negative bacteria --- Al-crus 3 and Al-crus 7 --- Trichoderma --- harziane diterpenes --- NO inhibition --- thioester-containing benzoate --- deep-sea-derived fungus --- α-glucosidase inhibitory activity --- docking study

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After the long history of screening, it is becoming difficult to find novel compounds from microorganisms and plants anywhere in the world. Until now, more than about 30,000 marine natural products have been reported. However, with the development of marine natural products research, the hit rate of new compounds is also decreasing. Scientists are now turning their attention to the deep sea, where a high hit rate of novel compounds is expected. Many small compounds and peptides from microorganisms and sponges are with therapeutic activity are shown in this book. This Special Issue Book, “Natural Products from the Deep Sea”, should be useful for the screening of novel and useful compounds from nature.

Medicine --- deep sea marine-derived fungus --- Myrothecium sp. --- myrothecol --- nitric oxide (NO) --- antioxidant activity --- macrolactam --- Deep-Sea-Derived Streptomyces --- abiotic formation --- natural product --- antifungal activity --- Thorectandra choanoides --- tryptophan alkaloid --- indoleamine 2,3-dioxygenase --- aplysinopsins --- GNPS molecular network --- cellular signal transduction --- bioactive metabolite --- deep-sea organisms --- anti-inflammatory agent --- anticancer agent --- Mariana Trench --- Micromonospora provocatoris MT25 --- desferrioxamine --- n-acetylglutaminyl glutamine amide --- 1H-15N 2D-NMR --- genomics --- biosynthetic gene clusters --- stress genes --- crustins --- antibacterial peptides --- hydrothermal vent --- anti-Gram-negative bacteria --- Al-crus 3 and Al-crus 7 --- Trichoderma --- harziane diterpenes --- NO inhibition --- thioester-containing benzoate --- deep-sea-derived fungus --- α-glucosidase inhibitory activity --- docking study --- deep sea marine-derived fungus --- Myrothecium sp. --- myrothecol --- nitric oxide (NO) --- antioxidant activity --- macrolactam --- Deep-Sea-Derived Streptomyces --- abiotic formation --- natural product --- antifungal activity --- Thorectandra choanoides --- tryptophan alkaloid --- indoleamine 2,3-dioxygenase --- aplysinopsins --- GNPS molecular network --- cellular signal transduction --- bioactive metabolite --- deep-sea organisms --- anti-inflammatory agent --- anticancer agent --- Mariana Trench --- Micromonospora provocatoris MT25 --- desferrioxamine --- n-acetylglutaminyl glutamine amide --- 1H-15N 2D-NMR --- genomics --- biosynthetic gene clusters --- stress genes --- crustins --- antibacterial peptides --- hydrothermal vent --- anti-Gram-negative bacteria --- Al-crus 3 and Al-crus 7 --- Trichoderma --- harziane diterpenes --- NO inhibition --- thioester-containing benzoate --- deep-sea-derived fungus --- α-glucosidase inhibitory activity --- docking study

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Many biodegradation pathways, both aerobic and anaerobic, have already been characterised, and the phylogenetic relationships among catabolic genes within them have been studied. However, new biodegradation activities and their coding genes are continuously being reported, including those involved in the catabolism of emerging contaminants and those generally regarded as non-biodegradable. Gene regulation is also an important issue for the efficient biodegradation of contaminants. Specific induction by the substrate and over-imposed global regulatory networks adjust the expression of the biodegradation genes to meet bacterial physiological needs. New biodegradation pathways can be assembled in a particular strain or in a bacterial consortium by recruiting biodegradation genes from different origins through horizontal gene transfer. The abundance and diversity of biodegradation genes, analysed by either genomic or metagenomic approaches, constitute valuable indicators of the biodegradation potential of a particular environmental niche. This knowledge paves the way to systems metabolic engineering approaches to valorise biowaste for the production of value-added products.

Research & information: general --- Biology, life sciences --- tetralin --- Sphingopyxis granuli strain TFA --- Rhodococcus sp. strain TFB --- redox proteins --- carbon catabolite repression --- plastics --- biodegradation --- sustainability --- upcycling --- biotransformations --- polyethylene terephthalate --- terephthalate --- ethylene glycol --- biphenyl --- bph gene --- integrative conjugative element --- genome sequence --- LysR --- transcription factor --- Acinetobacter --- LTTR --- benzoate --- muconate --- synergism --- biosensor --- naphthalene --- toluene --- hydrocarbons --- plant growth promotion --- bioremediation --- Pseudomonas --- soil pollution --- phytoremediation --- rhizoremediation --- diesel --- bacteria --- consortium --- metagenomics --- PAHs --- TPH --- regulation --- anaerobic --- Azoarcus --- promoter architecture --- bioethanol --- furfural --- ALE --- AraC --- sterols --- bile acids --- steroid hormones --- 9,10-seco pathway --- 4,5-seco pathway --- 2,3-seco pathway --- xenobiotics --- Carbaryl --- horizontal gene transfer --- mobile genetic elements --- transposons --- integrative conjugative elements --- pathway assembly --- evolution --- Sphingopyxis lindanitolerans --- pesticide --- complete genome sequence --- pangenome --- γ-HCH degradation --- lin genes --- testosterone --- steroid --- catabolism --- transcriptomic --- valorisation --- catabolic pathway --- mobile DNA --- anaerobic biodegradation --- gene regulation

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Pharmaceutical Preparations --- analysis --- Drugs --- Pharmaceutical chemistry --- Médicaments --- Chimie pharmaceutique --- Analysis --- Yearbooks. --- Analyse --- Pharmaceutical Preparations - analysis --- Atenolol --- Camphre --- Chloroquine --- Cholecalciferol --- Cimetidine --- Disopyramide (phosphate) --- Indomethacine --- Ketofifene --- Melphalan --- Moxalactam (disodium) --- Oxyphenbutazone --- Pentazocine --- Phenytoine --- Pyridoxine --- Reserpine --- Saccharine --- Salicylamide --- Sulfadadiazine argent --- Sulindac --- Tetracycline (chlorhydrate --- Tolbutamide --- Vitamine d3 --- CHLORTHALIDONE --- IMIPRAMINE HCl --- CISPLATIN --- ANALYTICAL PROFILE --- TRIPELENNAMINE HCl --- XYLOMETAZOLINE HCl --- MEFLOQUINE HCl --- ACIDE IOPOANOIQUE --- LIDOCAINE --- LIDOCAINE HCl --- BENPERIDOL --- HYDRATE DE TERPINE --- ATROPINE --- ISOPROTERENOL --- WARFARIN --- NALOXONE HCl --- DIFLUNISAL --- BACLOFEN --- ACETAMINOPHEN --- HALOTHANE --- Bacitracine --- Bretylium --- Carbamazepine --- Ccyproheptadine --- Cefaclor --- Cefamandole --- Dibenzepine --- Digoxine --- Doxorubicine --- Fluphenazine --- Gentamicine (sulfate) --- Griseofulvine --- Haloperidol --- Khellin --- Lorazepam --- Methadone --- Methoxsalen --- Monographies medicaments --- Nadolol --- Nitrazepam --- Nitroglycerin --- Trifluoroperazine --- Acide ascorbique --- Acide flufenamique --- Aminophylline --- Captopril --- Cefotaxime --- Cefoxitine sodium --- Clofibrate --- Clotrimazole --- Dopamine chlorhydrate --- Ergonovine maleate --- Hexestrol --- Mestranol --- Noscapine --- Penicilline-g benzathine --- Phenylbutazone --- Sulfadiazine --- Amantadine --- Amikacine sulfate --- Benzocaine --- Dibucaine --- Dibucaine chlorhydrate --- Dioctylsulfosuccinate de sodium --- Estrone --- Etomidate --- Heparine sodium --- Hydrocortisone --- Isopropamide --- Metoprolol tartrate --- Phenylpropanolamine chlorhydrate --- Pilocarpine --- Pyrazinamide --- Pyrimethamine --- Quinine chlorhydrate --- Quinine sulfate --- Rutine --- Trimipramine maleate --- AMILORIDE CHLORHYDRATE --- AMINOGLUTETHIMIDE --- CAFEINE --- COCAINE CHLORHYDRATE --- EPHEDRINE CHLORHYDRATE --- OESTRADIOL --- GUANABENZ ACETATE --- IODAMIDE --- LITHIUM CARBONATE --- MAPROTILINE CHLORHYDRATE --- PENICILLIN G --- POTASSIUM --- PIROXICAM --- RANITIDINE --- STRYCHNINE --- VIDARABINE --- ZOMEPIRAC --- SODIUM --- CHLORAMPHENICOL --- LIDOCAINE CHLORHYDRATE --- SODIUM NITROPRUSSIATE --- Acide aminosalicylique --- Azathioprine --- Benzoate de benzyle --- Chlorhydrate d'emetine --- Chlorhydrate de clindamycine --- Chlorhydrate de methylphenidate --- Colchicine --- Cyanocobalamine --- Glibenclamide --- Heroine --- Hydrochlorothiazide --- Ketoprofen --- Nabinole --- Natamycine --- Oxytocine --- Penicillamine --- Phosphate de codeine

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The aim of this Special Issue is to publish high quality papers concerning poultry nutrition and the interrelations between nutrition, metabolism, microbiota and the health of poultry. Therefore, I invite submissions of recent findings, as original research or reviews, on poultry nutrition, including, but not limited to, the following areas: the effect of feeding on poultry meat end egg quality; nutrient requirements of poultry; the use of functional feed additives to improve gut health and immune status; microbiota; nutraceuticals; soybean meal replacers as alternative sources of protein for poultry; the effects of feeding poultry on environmental impacts; the use of feed/food by-products in poultry diet; and feed technology.

Aflatoxin B1 --- Lactobacillus --- anti-fungal --- Aspergillus flavus --- in vitro --- poultry --- chickens --- ascorbic acid --- curcumin --- boric acid --- necrotic enteritis --- Salmonella Enteritidis --- broiler --- growth --- intestinal villi --- Salmonella --- broilers --- IBDV --- soybean isoflavones --- immune function --- viral protein 5 mRNA expression --- ducks --- zinc oxide --- phytase --- growth performance --- zinc utilization --- residual feed consumption --- quail --- high environmental temperature --- intestinal morphology --- duodenum --- intestinal absorption --- broilers feeding --- propolis --- bee pollen --- DHA --- omega-3 --- fatty acids --- enrichment --- selenium sources-levels --- selenium retention --- antioxidant capacity --- frozen meat --- embryonic development --- heat shock proteins --- immunoglobulin --- intracytoplasmic vacuoles --- L-arginine --- amino acids --- dietary supplementation --- humoral immunity --- Moringa oleifera --- laying performance --- health status --- energy requirement --- meat quality --- slow-growing broilers --- nutrient deposition --- xylanase --- arabinofuranosidases --- nutrient utilization --- immunity --- strain --- in ovo injection --- royal jelly --- chicken --- hatchability --- blood --- chitooligosaccharide --- intestinal integrity --- digestive function --- heat stress --- indigenous yellow-feathered breed --- denatonium benzoate --- genistein --- ggTas2Rs --- bitter taste receptors --- licorice --- Glycyrrhiza glabra --- beneficial effects --- pharmaceutical --- health --- turkey --- footpad dermatitis --- charcoal --- crude protein reduced diet --- compensatory growth --- omega-6 --- fatty acid --- nutrition --- performance --- antioxidant --- egg and meat quality --- fertility --- cholesterol --- CuZn-SOD --- HMG-CoA --- HSP70 --- laying hens --- L-Thr --- n/a --- vitamin B12 --- pekin ducks --- weight gain --- feed intake --- feed conversion ratio --- hematological indicator --- antibiotic --- hydrolysable polyphenol --- monoglyceride --- pathogen --- poultry feeding --- antioxidant status --- bamboo leaf extract --- cholesterol metabolism --- apoptosis --- autophagy --- heart --- kidney --- Camelina oil --- Camelina cake --- polyunsaturated fatty acids --- broiler chicken --- threonine --- metabolism --- blood parameter --- polyethylene glycol --- red grape pomace waste --- broiler chickens --- alternative energy source --- soybean lecithin --- phospholipids --- vegetable acid oil --- digestibility balance --- free fatty acids --- triacylglycerols --- mannanoligosaccharide --- oxidative status --- Partridge Shank chickens --- nanoparticles --- chromium --- supplementation --- electrophysiology --- Ussing chamber --- antibiotics --- intestinal health --- probiotics --- methionine --- reduced crude protein --- slaughter characteristics --- medicinal mushrooms --- Allium --- feed additive --- organosulfur compounds --- polyphenols --- levels --- sources --- carcass --- betaine --- Evans blue dye --- physiological responses --- feed additives --- prebiotics --- phytogenics --- organic acids --- anticoccidials --- Clostridium perfringens --- production performance --- essential oils --- housing system --- ISA brown --- production --- egg production --- green tea powder --- huainan partridge chicken --- lipoprotein lipase --- plasma lipid --- cadmium --- clay --- blood biochemical parameters --- multienzymes --- administration method --- enzyme dose --- blood constituents --- blood chemistry --- emulsifiers --- TBARs --- nutrient requirements --- growth indices --- modeling --- Chinese yellow-feathered chickens --- probiotic --- phytobiotic --- alternative ingredients --- lipid peroxidation --- biological nano-curcumin --- diet --- pathogens --- phytobiotics --- green tea --- pomegranate --- drinking water --- antiradical activity --- cecal microbiota --- SNP --- IGF1 --- IGFBP2 --- TGFß3 --- Hubbard F15 --- Cobb E --- meat --- bilberry leaves --- walnut leaves --- digestive enzyme activities --- blood haematology --- serum biochemistry