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Decades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segregation of areas within the prefrontal cortex, which underlie separate cognitive functions. Learning theory predictions have provided a very useful framework for interpreting the neural activity of dopamine neurons, yet even dopamine neurons present a range of responses, from salience to prediction error signaling. The functions of areas like the Lateral Habenula have been recently described, and its role, presumed to be substantial, is largely unknown. Many other neural systems interact with the dopamine system, like cortical GABAergic interneurons, making it critical to understand those systems and their interactions with dopamine in order to fully appreciate dopamine's role in flexible behavior. Advances in human clinical research, like exome sequencing, are driving experimental hypotheses which will lead to fruitful new research directions, but how do (or should?) these clinical findings inform basic research? Following new information from these techniques, we may begin to develop a fresh understanding of human disease states which will inform novel treatment possibilities. However, we need an operational framework with which to interpret these new findings. Therefore, the purpose of this Research Topic is to integrate what we know of dopamine, the prefrontal cortex and flexible behavior into a clear framework, which will illuminate clear, testable directions for future research.

behavioral flexibility --- Dopamine --- medial prefrontal cortex (mPFC) --- Attentional set-shifting --- basal forebrain --- anterior cingulate cortex (ACC) --- endocannabinoid system --- lateral habenula (LHb) --- Locus coeruleus (LC) --- motivational salience

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The kea, a crow-sized parrot that lives in the rugged mountains of New Zealand, is considered by some a playful comic and by others a vicious killer. Its true character is a mystery that biologists have debated for more than a century. Judy Diamond and Alan Bond have written a comprehensive account of the kea's contradictory nature, and their conclusions cast new light on the origins of behavioral flexibility and the problem of species survival in human environments everywhere.New Zealand's geological remoteness has made the country home to a bizarre assemblage of plants and animals that are wholly unlike anything found elsewhere. Keas are native only to the South Island, breeding high in the rigorous, unforgiving environment of the Southern Alps. Bold, curious, and ingeniously destructive, keas have a complex social system that includes extensive play behavior. Like coyotes, crows, and humans, keas are "open-program" animals with an unusual ability to learn and to create new solutions to whatever problems they encounter.Diamond and Bond present the kea's story from historical and contemporary perspectives and include observations from their years of field work. A comparison of the kea's behavior and ecology with that of its closest relative, the kaka of New Zealand's lowland rain forests, yields insights into the origins of the kea's extraordinary adaptability. The authors conclude that the kea's high level of sociality is a key factor in the flexible lifestyle that probably evolved in response to the alpine habitat's unreliable food resources and has allowed the bird to survive the extermination of much of its original ecosystem. But adaptability has its limits, as the authors make clear when describing present-day interactions between keas and humans and the attempts to achieve a peaceful coexistence.

Kea --- Evolution. --- Behavior. --- adaptability. --- adaptive behavior. --- alpine habitat. --- animal behavior. --- animals. --- behavioral flexibility. --- biology. --- bird. --- ecology. --- ecosystem. --- ethology. --- habitat. --- kaka. --- kea. --- life sciences. --- mountain birds. --- mountains. --- natural history. --- nature. --- new zealand. --- nonfiction. --- open program animals. --- ornithology. --- parrot. --- rainforest. --- science. --- southern alps. --- unforgiving environment. --- wild animals. --- wilderness. --- zoology.