Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.

Research & information: general --- elastin --- ribosomal protein SA --- tongue carcinoma --- MMP-2 --- EGCG --- pancreatic ductal adenocarcinoma --- syndecans --- proteoglycans --- tumor progression --- angiogenesis --- syndecan-4 --- heparan sulfate --- cancer --- prognosis --- biomarker --- signal transduction --- proteoglycan --- metastasis --- extracellular matrix --- fibrosis --- immune cell modulation --- neutrophils --- neutrophil extracellular trap --- macrophages --- BCC --- MMP --- TIMP --- invasion --- lumican --- cancer cell growth --- motility --- hyaluronan --- RHAMM --- CD44 --- wound repair --- breast cancer --- malignant pleural mesothelioma --- pleural effusion --- extracellular vesicles --- biomarkers --- sulfated hyaluronan --- estrogen receptors --- epithelial-to-mesenchymal transition --- matrix metalloproteinases --- elastin --- ribosomal protein SA --- tongue carcinoma --- MMP-2 --- EGCG --- pancreatic ductal adenocarcinoma --- syndecans --- proteoglycans --- tumor progression --- angiogenesis --- syndecan-4 --- heparan sulfate --- cancer --- prognosis --- biomarker --- signal transduction --- proteoglycan --- metastasis --- extracellular matrix --- fibrosis --- immune cell modulation --- neutrophils --- neutrophil extracellular trap --- macrophages --- BCC --- MMP --- TIMP --- invasion --- lumican --- cancer cell growth --- motility --- hyaluronan --- RHAMM --- CD44 --- wound repair --- breast cancer --- malignant pleural mesothelioma --- pleural effusion --- extracellular vesicles --- biomarkers --- sulfated hyaluronan --- estrogen receptors --- epithelial-to-mesenchymal transition --- matrix metalloproteinases

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.

Research & information: general --- elastin --- ribosomal protein SA --- tongue carcinoma --- MMP-2 --- EGCG --- pancreatic ductal adenocarcinoma --- syndecans --- proteoglycans --- tumor progression --- angiogenesis --- syndecan-4 --- heparan sulfate --- cancer --- prognosis --- biomarker --- signal transduction --- proteoglycan --- metastasis --- extracellular matrix --- fibrosis --- immune cell modulation --- neutrophils --- neutrophil extracellular trap --- macrophages --- BCC --- MMP --- TIMP --- invasion --- lumican --- cancer cell growth --- motility --- hyaluronan --- RHAMM --- CD44 --- wound repair --- breast cancer --- malignant pleural mesothelioma --- pleural effusion --- extracellular vesicles --- biomarkers --- sulfated hyaluronan --- estrogen receptors --- epithelial-to-mesenchymal transition --- matrix metalloproteinases --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

sektarisch denken --- sektarische neigingen --- sektarische bewegingen --- CGN --- de Noorse heiligingsbeweging --- Brunstad Christian Church --- Christelijke Gemeente Nederland --- de BCC --- Pagedal --- Brunstad --- acties voor fondswerving --- de kerntaken van een christelijke gemeente --- geloofsgemeenschap --- luxe en eenvoud --- commerciële activiteiten --- financiële transparantie --- de Gemeente des Heeren --- de exclusieve opstelling van een gesloten gemeenschap --- de Spade Regen Gemeente --- de Spade Regen Zending --- heiligmaking --- geloofshuizen --- kleding en media --- de 'Gemeenschap van Christenen' --- de Branham-boodschapsbeweging --- de eindtijdprofeet --- de zeven gemeentetijdperken --- de voorzegging over 1977 --- Nederland --- de Branham-boodschap --- evangeliediensten --- Christelijke gemeenschap zonder naam --- de Twee aan Twee-gemeenschap --- De Weg-gemeenschap --- Noorse broeders --- William Branham --- scheepsevangelisatie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recently, great attention has been paid to materials that can be used in the human body to prepare parts that replace failed bone structures. Of all materials, Ti-based materials are the most desirable, because they provide an optimum combination of mechanical, chemical, and biological properties. The successful application of Ti biomaterials has been confirmed mainly in dentistry, orthopedics, and traumatology. Titanium biocompatibility is practically the highest of all metallic biomaterials; however, new solutions are being sought to continuously improve their biocompatibility and osseointegration. Thus, the chemical modification of Ti results in the formation of new alloys or composites, which provide new perspectives for Ti biomaterials applications. This book covers broad aspects of Ti-based biomaterials concerning the design of their structure, mechanical, and biological properties. This book demonstrates that the new Ti-based compounds and their surface treatment provide the best properties for biomedical applications.

History of engineering & technology --- Powder Bed Fusion --- Titanium alloys --- Cobalt–Chrome alloys --- anisotropy --- bcc Ti-Mo-Zr alloys --- Inter-diffusion coefficient --- Impurity coefficient --- Atomic mobility --- CALPHAD modeling --- titanium --- low frequency --- inductive transmission --- metallic housing --- hermetic sealing --- longevity --- FEM model --- active implantable medical devices --- stainless --- nitinol --- diaphyseal fracture --- implant --- osseointegration --- biocompatibility --- bioactive ceramic coatings --- sphene --- ECAP --- Conform --- continuous extrusion --- wire --- medical implants --- plasma spraying --- Ti coating --- polymers --- biomaterials --- heat treatment --- in situ alloying --- laser additive manufacturing --- mechanical properties --- microstructure --- Ti–Nb alloy --- Ni-Ti alloy --- surface characteristics --- hydrophobic --- magnetic mixed EDM --- TiO2 nanotubes --- crystallization --- gaseous plasma --- biological response --- mechanical alloying --- nanoprecursor --- electric pulse-assisted sintering --- metal matrix composites --- titanium plate --- amine plasma --- surface modification --- hydrophilicity --- new bone formation --- titanium-based foams --- thermal dealloying --- titanium alloy --- biomaterial --- TiMoZrTa --- TiMoSi --- low elasticity modulus --- corrosion --- titanium alloys --- microstructures --- TNTZ --- copper --- Ti2Cu --- Ti3Cu --- antibacterial --- shape memory alloy --- temperature variable micro-compression test --- single crystal --- biomedical alloy --- selective electron beam additive manufacture --- Ti6Al4V ELI alloy --- phase transformation --- spatial --- gradient energy density --- martensitic decomposition --- Ti3Al intermetallic compound --- fracture analysis --- biofunctionalization --- Powder Bed Fusion --- Titanium alloys --- Cobalt–Chrome alloys --- anisotropy --- bcc Ti-Mo-Zr alloys --- Inter-diffusion coefficient --- Impurity coefficient --- Atomic mobility --- CALPHAD modeling --- titanium --- low frequency --- inductive transmission --- metallic housing --- hermetic sealing --- longevity --- FEM model --- active implantable medical devices --- stainless --- nitinol --- diaphyseal fracture --- implant --- osseointegration --- biocompatibility --- bioactive ceramic coatings --- sphene --- ECAP --- Conform --- continuous extrusion --- wire --- medical implants --- plasma spraying --- Ti coating --- polymers --- biomaterials --- heat treatment --- in situ alloying --- laser additive manufacturing --- mechanical properties --- microstructure --- Ti–Nb alloy --- Ni-Ti alloy --- surface characteristics --- hydrophobic --- magnetic mixed EDM --- TiO2 nanotubes --- crystallization --- gaseous plasma --- biological response --- mechanical alloying --- nanoprecursor --- electric pulse-assisted sintering --- metal matrix composites --- titanium plate --- amine plasma --- surface modification --- hydrophilicity --- new bone formation --- titanium-based foams --- thermal dealloying --- titanium alloy --- biomaterial --- TiMoZrTa --- TiMoSi --- low elasticity modulus --- corrosion --- titanium alloys --- microstructures --- TNTZ --- copper --- Ti2Cu --- Ti3Cu --- antibacterial --- shape memory alloy --- temperature variable micro-compression test --- single crystal --- biomedical alloy --- selective electron beam additive manufacture --- Ti6Al4V ELI alloy --- phase transformation --- spatial --- gradient energy density --- martensitic decomposition --- Ti3Al intermetallic compound --- fracture analysis --- biofunctionalization

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recently, great attention has been paid to materials that can be used in the human body to prepare parts that replace failed bone structures. Of all materials, Ti-based materials are the most desirable, because they provide an optimum combination of mechanical, chemical, and biological properties. The successful application of Ti biomaterials has been confirmed mainly in dentistry, orthopedics, and traumatology. Titanium biocompatibility is practically the highest of all metallic biomaterials; however, new solutions are being sought to continuously improve their biocompatibility and osseointegration. Thus, the chemical modification of Ti results in the formation of new alloys or composites, which provide new perspectives for Ti biomaterials applications. This book covers broad aspects of Ti-based biomaterials concerning the design of their structure, mechanical, and biological properties. This book demonstrates that the new Ti-based compounds and their surface treatment provide the best properties for biomedical applications.

History of engineering & technology --- Powder Bed Fusion --- Titanium alloys --- Cobalt–Chrome alloys --- anisotropy --- bcc Ti-Mo-Zr alloys --- Inter-diffusion coefficient --- Impurity coefficient --- Atomic mobility --- CALPHAD modeling --- titanium --- low frequency --- inductive transmission --- metallic housing --- hermetic sealing --- longevity --- FEM model --- active implantable medical devices --- stainless --- nitinol --- diaphyseal fracture --- implant --- osseointegration --- biocompatibility --- bioactive ceramic coatings --- sphene --- ECAP --- Conform --- continuous extrusion --- wire --- medical implants --- plasma spraying --- Ti coating --- polymers --- biomaterials --- heat treatment --- in situ alloying --- laser additive manufacturing --- mechanical properties --- microstructure --- Ti–Nb alloy --- Ni-Ti alloy --- surface characteristics --- hydrophobic --- magnetic mixed EDM --- TiO2 nanotubes --- crystallization --- gaseous plasma --- biological response --- mechanical alloying --- nanoprecursor --- electric pulse-assisted sintering --- metal matrix composites --- titanium plate --- amine plasma --- surface modification --- hydrophilicity --- new bone formation --- titanium-based foams --- thermal dealloying --- titanium alloy --- biomaterial --- TiMoZrTa --- TiMoSi --- low elasticity modulus --- corrosion --- titanium alloys --- microstructures --- TNTZ --- copper --- Ti2Cu --- Ti3Cu --- antibacterial --- shape memory alloy --- temperature variable micro-compression test --- single crystal --- biomedical alloy --- selective electron beam additive manufacture --- Ti6Al4V ELI alloy --- phase transformation --- spatial --- gradient energy density --- martensitic decomposition --- Ti3Al intermetallic compound --- fracture analysis --- biofunctionalization