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Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird’s eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented.

bioenvironmental control --- model-predictive controller --- zonal controlling --- dynamic modelling --- flotation --- bioleaching --- frother --- mixed culture --- machine learning --- Raman spectroscopy --- downstream processing --- chromatography --- flow cell --- extended Kalman filter --- biotechnological processes --- bioreactor control --- specific growth rate control --- batch-to-batch reproducibility --- thermal sensation --- thermal comfort --- machine-learning --- prediction --- adaptive controlling --- thermal growth curve --- temperature modeling --- thermoregulation --- monitoring and control --- bioprocess engineering --- calorimetry --- biocontrol agent --- Bacillus subtilis natto --- isolation --- molecular identification --- medium optimization --- antimicrobial activity --- bactericides --- spectral analyses --- biological selenate reduction --- electron donor competition --- nitrate --- perchlorate --- sequencing batch --- Pseudomonas --- siderophores --- antagonism --- batch fermentation --- exponential fed-batch fermentation --- bio-friendly formulations --- biocontrol --- nonlinear state estimation --- geometric observer --- bioreactor --- continuous system --- model-based sensor --- well-defined macromolecules --- sequence-defined macromolecules --- sequence-defined polymers --- conjugated oligomers --- oligo(arylene ethynylene)s --- biosensors --- sensors --- process monitoring --- bioprocess monitoring and control --- signal noise management --- dielectric spectroscopy --- PAT --- microbial bioprocessing --- n/a

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Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.

Coreopsis lanceolata L. --- UV-Vis --- methanogenesis --- Lythraceae --- flavanone --- grape marc --- TDDFT --- Ephedra sinica --- macrocyclic oligomer --- triple-negative breast cancer --- antioxidant --- purple prairie clover --- chalcone --- neuraminidase --- fatty acid synthase --- (?)-epigallocatechin gallate --- epidermal growth factor --- NMR spectroscopy --- Aluminum ion --- Onagraceae --- Hydrangea macrophylla --- synthetic analogues --- blue color development --- amyloid-? peptide --- FTIR --- oseltamivir carboxylate --- quantitative NMR --- phloroglucinolysis --- thin layer chromatography --- European historic leathers --- FASN inhibition --- ECD --- colorimetric tests --- taxanes --- cynandione A --- conservation method --- 5-O-caffeoylquinic acid --- ellagitannin --- PC12 --- condensed tannin --- Trapa taiwanensis Nakai --- 1H-NMR --- Acacia --- (?)-epigallocatechin 3-gallate --- Geranium thunbergii --- condensed tannins --- immunomodulatory effect --- Acacia mearnsii bark --- Escherichia coli --- oligomer --- Horner–Wadsworth–Emmons reaction --- lung tumor --- Aspergillus fumigates --- in vitro batch fermentation --- metal complex --- Myrtaceae --- Cynanchum auriculatum --- molecular interactions --- phenolic glycoside --- bamboo leaf extract --- stability --- Microsporum canis --- Cynanchum wilfordii --- thiolysis --- anti-inflammation --- hydrolysable tannin --- geraniin --- NGF --- polyphenol --- revision --- ESI-mass --- bioactivity --- antifungal activities --- interferon-? --- antitumor effect --- tannin composition --- oenothein B --- zanamivir --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- anticancer activity --- proanthocyanidin --- vegetable tanning --- Dittrichia viscosa --- differentiation --- aurone --- antioxidants --- protein precipitation --- apoptosis --- polyphenolic FASN inhibitors --- forage legume --- biological activities --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- overlay method --- spectroscopy --- wattle tannin --- immune checkpoint --- hormesis --- 3-O-glucosyldelphinidin --- gallotannin --- proanthocyanidins --- fatty acids --- flavonol --- inhibition --- structure --- Candida spp. --- Malassezia spp. --- ORAC assay --- neuroprotection --- crystal structure --- tannins

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Nowadays, we are witnessing highly dynamic research activities related to the intriguing field of biodegradable materials with plastic-like properties. These activities are stimulated by the strengthened public awareness of prevailing ecological issues connected to growing piles of plastic waste and increasing greenhouse gas emissions; this goes hand-in-hand with the ongoing depletion of fossil feedstocks, which are traditionally used to produce full carbon backbone polymers. Polyhydroxyalkanoate (PHA) biopolyesters, a family of plastic-like materials with versatile material properties, are increasing considered to be a future-oriented solution for diminishing these concerns. PHA production is based on renewable resources and occurs in a bio-mediated fashion through the action of living organisms. If accomplished in an optimized way, PHA production and the entire PHA lifecycle are embedded into nature´s closed cycles of carbon. Sustainable and efficient PHA production requires understanding and improvement of all the individual process steps. Holistic improvement of PHA production, applicable on an industrially relevant scale, calls for, inter alia, consolidated knowledge about the enzymatic and genetic particularities of PHA-accumulating organisms, an in-depth understanding of the kinetics of the bioprocess, the selection of appropriate inexpensive fermentation feedstocks, tailoring of PHA composition at the level of its monomeric constituents, optimized biotechnological engineering, and novel strategies for PHA recovery from biomass characterized by low energy and chemical requirements. This Special Issue represents a comprehensive compilation of articles in which these individual aspects have been addressed by globally recognized experts.

Cupriavidus necator --- alginate --- tissue engineering --- PAT --- simulation --- terpolyester --- high cell density cultivation --- process simulation --- selective laser sintering --- gaseous substrates --- microaerophilic --- in-line monitoring --- Pseudomonas sp. --- additive manufacturing --- fed-batch --- terpolymer --- on-line --- bubble column bioreactor --- biopolymer --- fused deposition modeling --- biomaterials --- polyhydroxyalkanoate (PHA) --- Pseudomonas putida --- fed-batch fermentation --- blends --- upstream processing --- wound healing --- activated charcoal --- downstream processing --- Archaea --- polyhydroxyalkanoates processing --- film --- bioreactor --- medium-chain-length polyhydroxyalkanoate (mcl-PHA) --- poly(3-hydroxybutyrate-co-4-hydroxybutyrate) --- Ralstonia eutropha --- hydrolysate detoxification --- extremophiles --- Poly(3-hydroxybutyrate) --- process analytical technologies --- PHA composition --- COMSOL --- non-Newtonian fluid --- tequila bagasse --- biopolyester --- biosurfactants --- Haloferax --- PHA --- phenolic compounds --- polyhydroxybutyrate --- PHB --- in-line --- Pseudomonas --- haloarchaea --- plant oil --- PHA processing --- bioeconomy --- delivery system --- P(3HB-co-3HV-co-4HB) --- productivity --- electrospinning --- cyanobacteria --- waste streams --- polyhydroxyalkanoates --- oxygen transfer --- polyhydroxyalkanoate --- biomedical application --- photon density wave spectroscopy --- carbon dioxide --- salinity --- PDW --- rheology --- halophiles --- feedstocks --- high-cell-density fed-batch --- biomedicine --- process engineering --- bioprocess design --- viscosity --- computer-aided wet-spinning --- microorganism --- Cupriavidus malaysiensis --- poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHVB)