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lipid metabolism --- cardiovascular disease --- basic research --- nutrition --- atherosclerosis --- thrombosis
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Health Sciences --- Orthopaedics --- Surgery --- orthopedic epidemiology --- orthopedic surgery --- orthopedic regenerative medicine --- orthopedic robotic surgery --- orthopedic basic research
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Cardiac pacing --- Electrophysiology --- Cardiac Pacing, Artificial. --- Electrophysiology. --- Cardiac pacing. --- Engineering --- Health Sciences --- Electronics --- Cardiology --- Physiology --- cardiac pacing --- and electrophysiology including basic research --- electrophysiology
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Skin Diseases. --- Pathology. --- Skin --- Peau --- Diseases --- Periodicals. --- Maladies --- Périodiques --- Pathologies --- Disease --- Dermatosis --- Dermatoses --- Disease, Skin --- Diseases, Skin --- Skin Disease --- pathology --- Dermatology --- Clinical Research --- Basic Research --- Cutaneous diseases --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Pathological dermatology --- Skin and Subcutaneous Tissue Disorders --- dermatologie --- dermatology --- clinical research --- basic research --- Diseases.
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Human anatomy --- Pathology --- Translational Medical Research. --- Anatomy. --- Research --- Research. --- Anatomies --- Knowledge Translation --- Translational Medical Science --- Translational Medicine --- Translational Research, Medical --- Translational Research --- Knowledge Translations --- Medical Research, Translational --- Medical Science, Translational --- Medical Sciences, Translational --- Medical Translational Research --- Medicine, Translational --- Research, Medical Translational --- Research, Translational --- Research, Translational Medical --- Science, Translational Medical --- Sciences, Translational Medical --- Translation, Knowledge --- Translational Medical Sciences --- Translational Researchs --- Translations, Knowledge --- Anatomy, Human --- Disease (Pathology) --- anatomy --- translational research --- application of basic research at clinical level --- human pathology --- National Center for Advancing Translational Sciences (U.S.) --- Anatomy --- Human biology --- Medical sciences --- Human body --- Diseases --- Medicine --- Medicine, Preventive --- Translational Research, Biomedical --- Translational Research, Biomedical.
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Clinical Medicine --- Medicine --- Médecine --- Periodicals. --- Périodiques --- Medicine. --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Periodicals --- Health Sciences --- General and Others --- Immunology --- Life Sciences --- Health Sciences. --- Immunology. --- Life Sciences. --- medicine --- basic research --- Medicine, Clinical --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Clinical Medicine. --- Switzerland. --- Confederatio Helvetica --- Confédération de huit cantons --- Confédération suisse --- Confederazione svizzera --- Confederaziun svizra --- Eidgenossenschaft --- Everlasting League --- Four Forest Cantons --- Helvetia --- Helvetic Confederation --- Lega elvetica --- Schweiz --- Schweizerische Eidgenossenschaft --- Schweizerische Eidtgenossenschaft --- Shṿaits --- Shveĭt͡sarii͡ --- Shveytsʻaria --- Suisse --- Suisu --- Suiza --- Sŭwis --- Sveitsi --- Sviṭzaralaiṇḍa --- Svizra --- Svizzera --- Swiss Confederation --- Swisserland --- Switzerland --- Vier Waldstätte --- Zvicra --- Zwitserland --- Shveĭt︠s︡arii︠a︡ --- Sŭwisŭ --- ConfeÌdeÌration de huit cantons --- ConfeÌdeÌration suisse --- ShvÌ£aits --- ShveiÌtï¸ s︡ariiï¸ a︡ --- ShveytsÊ»aria --- SuÌwisuÌ --- SvitÌ£zaralainÌ£dÌ£a --- Vier WaldstaÌtte
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Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.
receptor activator of nuclear factor ?B --- infliximab --- tripterine --- triptolide --- osteoblast --- tumor necrosis factor-alpha --- synovial cell --- anti-arthritis --- biosimilars --- Epstein-Barr virus --- cytokines --- SOX9 --- parathyroid hormone --- nitric oxide --- rat --- etanercept --- angiogenesis --- glycosylation --- mitogen activated protein kinase --- Th9 lymphocytes --- rheumatoid arthritis --- IL-6 --- clodronate --- bone erosion --- mesenchymal stem cells --- collagen-induced arthritis --- biological --- gene expression --- inflammatory arthritis --- osteoarthritis --- fraxinellone --- nuclear factor kappa B --- messenger RNA --- inflammation --- miRNA --- disease-modifying --- adipokines --- WNT --- glycoprotein 42 --- miR-199a-5p --- proliferation --- next-generation sequencing --- collagen --- osteoarthritis (OA) --- experimental arthritis --- bone morphogenetic protein --- TNF-? --- computational modeling --- basic research --- osteoclast --- therapeutics --- certolizumab pegol --- chondrocytes --- progenitor cells --- adjuvant arthritis --- adalimumab --- triterpenoid --- sclareol --- TNF? --- fibroblast growth factor 2 --- antibodies --- osteoblasts --- molecular pathology --- Th17 --- immunology --- obesity --- visfatin --- articular cartilage --- autoimmune --- biomarkers --- celastrol --- MAPK --- disease pathways --- IL1? --- arthritis --- bioinformatics --- anticitrullinated peptide antibodies --- drug delivery system --- antagonists --- shared epitope --- pathology --- SMA- and MAD-related protein --- small-molecule inhibitor --- transforming growth factor ? --- mice --- golimumab --- spinal fusion --- antirheumatic drug --- early osteoarthritis --- stem cell --- rheumatoid factor --- therapeutic antibody --- bisphosphonate --- osteoclastogenesis --- interleukin --- spondyloarthropathies --- clinical translation --- therapy --- Traditional Chinese medicine --- chemokines --- structure --- cell signaling --- microRNA
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In today's unpredictable and chaotic world, we look to science to provide certainty and answers--and often blame it when things go wrong. The Blind Spot reveals why our faith in scientific certainty is a dangerous illusion, and how only by embracing science's inherent ambiguities and paradoxes can we truly appreciate its beauty and harness its potential. Crackling with insights into our most perplexing contemporary dilemmas, from climate change to the global financial meltdown, this book challenges our most sacredly held beliefs about science, technology, and progress. At the same time, it shows how the secret to better science can be found where we least expect it--in the uncertain, the ambiguous, and the inevitably unpredictable. William Byers explains why the subjective element in scientific inquiry is in fact what makes it so dynamic, and deftly balances the need for certainty and rigor in science with the equally important need for creativity, freedom, and downright wonder. Drawing on an array of fascinating examples--from Wall Street's overreliance on algorithms to provide certainty in uncertain markets, to undecidable problems in mathematics and computer science, to Georg Cantor's paradoxical but true assertion about infinity--Byers demonstrates how we can and must learn from the existence of blind spots in our scientific and mathematical understanding. The Blind Spot offers an entirely new way of thinking about science, one that highlights its strengths and limitations, its unrealized promise, and, above all, its unavoidable ambiguity. It also points to a more sophisticated approach to the most intractable problems of our time.
Uncertainty (Information theory) --- Science --- Measure of uncertainty (Information theory) --- Shannon's measure of uncertainty --- System uncertainty --- Information measurement --- Probabilities --- Questions and answers --- Science and society --- Sociology of science --- Social aspects. --- Acknowledgment (creative arts and sciences). --- Algorithm. --- Ambiguity. --- Analogy. --- Approximation. --- Axiom. --- Axiomatic system. --- Basic research. --- Big O notation. --- Calculation. --- Certainty. --- Chaos theory. --- Circumference. --- Computation. --- Concept. --- Conjecture. --- Consciousness. --- Consistency. --- Contingency (philosophy). --- Continuous function. --- Continuum hypothesis. --- Contradiction. --- Counting. --- David Bohm. --- Dynamism (metaphysics). --- Emergence. --- Euclidean geometry. --- Explanation. --- Feeling. --- Fermat's Last Theorem. --- Geometry. --- Gestalt psychology. --- Gregory Chaitin. --- Gödel's incompleteness theorems. --- Human behavior. --- Human intelligence. --- Hypothesis. --- Ideology. --- Inference. --- Integer. --- Irrational number. --- Learning. --- Logic. --- Logical reasoning. --- Mathematician. --- Mathematics. --- Measurement. --- Methodology. --- Modernity. --- Molecule. --- Natural number. --- Nature. --- Paradigm shift. --- Paradox. --- Participant. --- Phenomenon. --- Philosopher. --- Philosophy of mathematics. --- Philosophy of science. --- Philosophy. --- Platonism. --- Prediction. --- Principle. --- Probability. --- Pythagoreanism. --- Qualitative property. --- Quantification (science). --- Quantity. --- Quantum mechanics. --- Randomness. --- Rational number. --- Rationality. --- Real number. --- Reality. --- Reason. --- Reductionism. --- Relationship between religion and science. --- Result. --- Science. --- Scientific method. --- Scientific progress. --- Scientific theory. --- Scientist. --- Self-reference. --- Set theory. --- Special case. --- Subatomic particle. --- Subjectivity. --- Suggestion. --- Technology. --- The Philosopher. --- Theorem. --- Theoretical physics. --- Theory of everything. --- Theory. --- Thomas Kuhn. --- Thought. --- Uncertainty. --- Universality (philosophy). --- Writing. --- Sociology of knowledge
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Robert John Ackermann deals decisively with the problem of relativism that has plagued post-empiricist philosophy of science. Recognizing that theory and data are mediated by data domains (bordered data sets produced by scientific instruments), he argues that the use of instruments breaks the dependency of observation on theory and thus creates a reasoned basis for scientific objectivity.Originally published in 1985.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Logic. --- Science --- Argumentation --- Deduction (Logic) --- Deductive logic --- Dialectic (Logic) --- Logic, Deductive --- Intellect --- Philosophy --- Psychology --- Reasoning --- Thought and thinking --- Science and society --- Sociology of science --- Normal science --- Philosophy of science --- Social aspects. --- Philosophy. --- Methodology --- Ad hominem. --- Alternative hypothesis. --- Analogy. --- Analytic–synthetic distinction. --- Basic research. --- Bayesian probability. --- Behavioural sciences. --- Branches of science. --- Calculation. --- Case study. --- Circumlocution. --- Concept. --- Consciousness. --- Critical theory. --- Decision-making. --- Deductive-nomological model. --- Design of experiments. --- Dialectic. --- Emergence. --- Empiricism. --- Engineering. --- Epistemology. --- Experiment. --- Experimental data. --- Explanation. --- Explanatory model. --- Fact. --- Finalization. --- Form of life (philosophy). --- Grand theory. --- Heuristic. --- Historical method. --- Historicism. --- Holism. --- Human science. --- Hypothesis. --- Hypothetico-deductive model. --- Idealization. --- Ideology. --- Inductive reasoning. --- Inference. --- Instrumentalism. --- Interaction. --- Knowledge and Human Interests. --- Laboratory Life. --- Mathematics. --- Mechanism design. --- Methodology. --- Modern physics. --- Natural science. --- Objectivity (science). --- Observation. --- Ontology. --- Paradigm shift. --- Paradigm. --- Phenomenon. --- Philosopher. --- Philosophical analysis. --- Philosophical theory. --- Philosophy of science. --- Phrenology. --- Planck's principle. --- Positivism. --- Potentiality and actuality. --- Prediction. --- Probability theory. --- Proofs and Refutations. --- Pseudoscience. --- Quantification (science). --- Reagent. --- Reason. --- Relativism. --- Research program. --- Result. --- Science policy. --- Science. --- Scientific method. --- Scientific progress. --- Scientific realism. --- Scientific theory. --- Scientist. --- Situational analysis. --- Sociology. --- Sophistication. --- Subjectivism. --- Testability. --- The Conceptual Framework. --- The Structure of Science. --- Theoretical definition. --- Theoretical physics. --- Theory. --- Thomas Kuhn. --- Thought experiment. --- Thought. --- Transcendental arguments. --- Type theory. --- Utilitarianism. --- Verificationism. --- Verisimilitude.
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A revealing and provocative look at the current state of global scienceWe take the advance of science as given. But how does science really work? Is it truly as healthy as we tend to think? How does the system itself shape what scientists do? The Secret Life of Science takes a clear-eyed and provocative look at the current state of global science, shedding light on a cutthroat and tightly tensioned enterprise that even scientists themselves often don't fully understand.The Secret Life of Science is a dispatch from the front lines of modern science. It paints a startling picture of a complex scientific ecosystem that has become the most competitive free-market environment on the planet. It reveals how big this ecosystem really is, what motivates its participants, and who reaps the rewards. Are there too few scientists in the world or too many? Are some fields expanding at the expense of others? What science is shared or published, and who determines what the public gets to hear about? What is the future of science? Answering these and other questions, this controversial book explains why globalization is not necessarily good for science, nor is the continued growth in the number of scientists. It portrays a scientific community engaged in a race for limited resources that determines whether careers are lost or won, whose research visions become the mainstream, and whose vested interests end up in control.The Secret Life of Science explains why this hypercompetitive environment is stifling the diversity of research and the resiliency of science itself, and why new ideas are needed to ensure that the scientific enterprise remains healthy and vibrant.
Science --- Scientists --- Communication in science. --- Discoveries in science. --- Social aspects. --- Methodology. --- Training of. --- Professional employees --- Scientific method --- Logic, Symbolic and mathematical --- Breakthroughs, Scientific --- Discoveries, Scientific --- Scientific breakthroughs --- Scientific discoveries --- Creative ability in science --- Research --- Communication in research --- Science communication --- Science information --- Scientific communications --- Science and society --- Sociology of science --- Academic publishing. --- Advertising. --- Analogy. --- Applied science. --- Apprenticeship. --- Author. --- Basic research. --- Basic science (psychology). --- Big Science. --- Biochemistry. --- Biologist. --- Biology. --- Blog. --- Brand. --- Career. --- Climate change. --- Collaboration. --- Competition. --- Competitiveness. --- Consortium. --- Credibility. --- Currency. --- Diagram. --- Dissemination. --- Doctor of Philosophy. --- Douglas Hofstadter. --- Ecology. --- Ecosystem services. --- Ecosystem. --- Editorial. --- Electron microscope. --- Electronic publishing. --- Emerging technologies. --- Employment. --- Energy development. --- Engineering. --- Experiment. --- Funding of science. --- Funding. --- Globalization. --- High tech. --- Human resources. --- IT Works. --- Impact factor. --- Income. --- Infrastructure. --- Institution. --- Internship. --- James Gleick. --- Journalism. --- Know-how. --- Lecture. --- Materials science. --- Molecule. --- Nanotechnology. --- Narrative. --- Natural resource. --- Nature of Science. --- New Scientist. --- Newspaper. --- Nobel Prize. --- Particle accelerator. --- Particle physics. --- Peer review. --- Physical chemistry. --- Physicist. --- Politician. --- Popular science. --- Postdoctoral researcher. --- Prediction. --- Problem solving. --- Project. --- Publication. --- Publicity. --- Publishing. --- Quantum mechanics. --- Reputation. --- Research and development. --- Research associate. --- Research program. --- Salary. --- Scaffolding. --- Science fiction. --- Science journalism. --- Science policy. --- Science project. --- Science. --- Scientific American. --- Scientific method. --- Scientist. --- Statistic. --- Subatomic particle. --- Subsidy. --- Suggestion. --- Tax. --- Technology. --- Wealth. --- Web of Science. --- Writing. --- Year.
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