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Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
Technology: general issues --- NQO1 --- NQO1*2 --- polymorphism --- quinone --- breast cancer --- menadione --- lapachone --- doxorubicin --- ascorbate --- oxidative stress --- reactive oxygen species --- sperm --- cancer chemotherapy --- antioxidant therapy --- antioxidant proteins --- chemoresistance --- oxaliplatin --- 5-Fluorouracil --- myelodysplastic syndromes --- carbonylation --- deferasirox --- ovary --- calcium channel --- Trolox --- granulosa cell tumor --- cell death --- mitochondria --- photodynamic therapy --- singlet oxygen --- nitric oxide --- light --- combination therapy --- antioxidants --- bleomycin --- cancer treatment --- chemotherapy-induced toxicity --- cisplatin --- free radicals --- methotrexate --- ozone therapy --- lung cancer --- cancer metabolism --- reactive oxygen species (ROS) --- therapy resistance --- new therapeutic strategies --- breast cancer stem cells --- 4-hydroxy-2-nonenal --- extracellular matrix --- NRF2 --- bardoxolone methyl --- prostate cancer --- castration-resistant prostate cancer --- androgen receptor (AR), AR-V7 --- anti-androgen --- enzalutamide --- androgen deprivation therapy --- cancer --- antioxidant --- triphala --- ayurveda --- chemoprevention and chemotherapy --- NQO1 --- NQO1*2 --- polymorphism --- quinone --- breast cancer --- menadione --- lapachone --- doxorubicin --- ascorbate --- oxidative stress --- reactive oxygen species --- sperm --- cancer chemotherapy --- antioxidant therapy --- antioxidant proteins --- chemoresistance --- oxaliplatin --- 5-Fluorouracil --- myelodysplastic syndromes --- carbonylation --- deferasirox --- ovary --- calcium channel --- Trolox --- granulosa cell tumor --- cell death --- mitochondria --- photodynamic therapy --- singlet oxygen --- nitric oxide --- light --- combination therapy --- antioxidants --- bleomycin --- cancer treatment --- chemotherapy-induced toxicity --- cisplatin --- free radicals --- methotrexate --- ozone therapy --- lung cancer --- cancer metabolism --- reactive oxygen species (ROS) --- therapy resistance --- new therapeutic strategies --- breast cancer stem cells --- 4-hydroxy-2-nonenal --- extracellular matrix --- NRF2 --- bardoxolone methyl --- prostate cancer --- castration-resistant prostate cancer --- androgen receptor (AR), AR-V7 --- anti-androgen --- enzalutamide --- androgen deprivation therapy --- cancer --- antioxidant --- triphala --- ayurveda --- chemoprevention and chemotherapy
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Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.
varioxiranol A --- natural enantiomer --- n/a --- ribosomally synthesized --- triterpenoids --- apo-CpcB --- water resistance --- radical scavenger --- bardoxolone methyl --- antioxidant activity --- octadecanoid --- derivatives --- inhibitor --- chlorogenic acid --- biosynthesis --- microbial biosynthesis --- flow cytometry --- adhesive --- phycocyanin --- antioxidant --- anticancer drug --- resource chemistry --- ginkgolide --- anti-inflammation --- salt stress --- polyphenol --- synthesis of natural products --- rheumatoid arthritis --- PEGylated purpurin 18 --- photosensitizer --- RiPP --- isosorbide --- bioactivity --- cell opening --- stilbene --- tea tussock moth --- flavonoids --- flexible polyurethane foam --- gene expression --- genetical transformation --- research progress --- oleic acid-elicited --- pharmacokinetic features --- phenolic acid --- Plantago depressa --- platelet-activating factor receptor --- photodynamic therapy --- fatty acid --- soy protein isolate --- apoptosis --- HepG2 cells --- cancer cells --- live-cell fluorescence microscopy --- tomato --- caffeoylquinic acids --- pinocembrin --- insect sex pheromone --- 4-epi-varioxiranol A --- natural products --- singlet oxygen --- total synthesis --- lipid-lowering effects --- reversible urethane linkages --- cytotoxicity --- bromelain --- Ramulus mori --- polysaccharides --- SlCOMT1 --- pharmacological activities --- absolute structure --- natural product --- mitochondria --- Emericella variecolor --- triglycidylamine --- Spirulina --- viscosity --- post-translationally modified peptides --- phototoxicity --- melatonin
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Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
Technology: general issues --- NQO1 --- NQO1*2 --- polymorphism --- quinone --- breast cancer --- menadione --- lapachone --- doxorubicin --- ascorbate --- oxidative stress --- reactive oxygen species --- sperm --- cancer chemotherapy --- antioxidant therapy --- antioxidant proteins --- chemoresistance --- oxaliplatin --- 5-Fluorouracil --- myelodysplastic syndromes --- carbonylation --- deferasirox --- ovary --- calcium channel --- Trolox --- granulosa cell tumor --- cell death --- mitochondria --- photodynamic therapy --- singlet oxygen --- nitric oxide --- light --- combination therapy --- antioxidants --- bleomycin --- cancer treatment --- chemotherapy-induced toxicity --- cisplatin --- free radicals --- methotrexate --- ozone therapy --- lung cancer --- cancer metabolism --- reactive oxygen species (ROS) --- therapy resistance --- new therapeutic strategies --- breast cancer stem cells --- 4-hydroxy-2-nonenal --- extracellular matrix --- NRF2 --- bardoxolone methyl --- prostate cancer --- castration-resistant prostate cancer --- androgen receptor (AR), AR-V7 --- anti-androgen --- enzalutamide --- androgen deprivation therapy --- cancer --- antioxidant --- triphala --- ayurveda --- chemoprevention and chemotherapy --- n/a
Choose an application
Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
NQO1 --- NQO1*2 --- polymorphism --- quinone --- breast cancer --- menadione --- lapachone --- doxorubicin --- ascorbate --- oxidative stress --- reactive oxygen species --- sperm --- cancer chemotherapy --- antioxidant therapy --- antioxidant proteins --- chemoresistance --- oxaliplatin --- 5-Fluorouracil --- myelodysplastic syndromes --- carbonylation --- deferasirox --- ovary --- calcium channel --- Trolox --- granulosa cell tumor --- cell death --- mitochondria --- photodynamic therapy --- singlet oxygen --- nitric oxide --- light --- combination therapy --- antioxidants --- bleomycin --- cancer treatment --- chemotherapy-induced toxicity --- cisplatin --- free radicals --- methotrexate --- ozone therapy --- lung cancer --- cancer metabolism --- reactive oxygen species (ROS) --- therapy resistance --- new therapeutic strategies --- breast cancer stem cells --- 4-hydroxy-2-nonenal --- extracellular matrix --- NRF2 --- bardoxolone methyl --- prostate cancer --- castration-resistant prostate cancer --- androgen receptor (AR), AR-V7 --- anti-androgen --- enzalutamide --- androgen deprivation therapy --- cancer --- antioxidant --- triphala --- ayurveda --- chemoprevention and chemotherapy --- n/a
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