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Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

Bacterial toxins. --- Bacterial antigens --- Microbial toxins

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Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.

Bacterial toxins. --- Bacterial antigens --- Microbial toxins

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Bacterial toxins --- 579.6 --- 615 --- 579.6 Applied microbiology --- Applied microbiology --- Bacterial antigens --- Microbial toxins --- Pharmacology. Therapeutics. Toxicology --- Bacterial proteins

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Neisseria. --- Bacterial antigens --- Gonorrhea --- -Meningitis --- -Neisseria gonorrhoeae --- Neisseria meningitidis --- Meningococcus --- Meningitis --- Neisseria --- Diplococcus gonorrhoeae --- Gonococcus --- Micrococcus gonorrhoea --- Neisser's coccus --- Leptomeningitis --- Central nervous system --- Genitourinary organs --- Neisseria infections --- Sexually transmitted diseases --- Urethritis --- Antigens --- Bacteria --- Microbiology --- Diseases --- Infections --- Bacterial antigens. --- Neisseria gonorrhoeae. --- Neisseria meningitidis. --- Microbiology. --- congresses. --- Congresses. --- Neisseria gonorrhoeae

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This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Life Sciences. --- Microbiology. --- Life sciences. --- Sciences de la vie --- Microbiologie --- Streptococcus pyogenes. --- Superantigens. --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Streptococcus hemolyticus --- Streptococcus --- Bacterial antigens --- Viral antigens --- Microbial biology --- Microorganisms