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Cardiovascular diseases are the first cause of death worldwide, in which genetic and environmental factors seem to play a determinant role. In fact, several lifestyle (i.e., dietary, physical inactivity) factors and nutritional-related diseases (i.e., obesity, type 2 diabetes) are strongly associated with cardiovascular diseases. Moreover, genome-wide association studies have also identified numerous genomic loci that determine susceptibility to cardiovascular events. Therefore, nutrition and genetics seem to interact in predisposing an individual to cardiovascular diseases. This book provides a presentation of recent advances in knowledge on nutrition, genetics, and cardiovascular disease coming from diverse scientific disciplines.

Medicine --- renin-angiotensin-aldosterone system --- tissue --- expression --- physiology --- dietary intake --- nutrition --- cardiovascular disease --- obesity --- hookah --- overweight --- shisha --- abdominal obesity --- weight management --- treatment --- adolescents --- arterial stiffness --- birth weight --- body-size trajectories --- cardio-metabolic health --- children --- growth --- intima-media thickness --- blood pressure --- acute rheumatic fever --- rheumatic heart diseases --- MT-CYB --- mutation --- Senegal --- hypercholesterolemia --- cluster of differentiation 14 --- rs2569190A&gt --- G --- single nucleotide polymorphisms --- association analysis --- renin-angiotensin-aldosterone system --- tissue --- expression --- physiology --- dietary intake --- nutrition --- cardiovascular disease --- obesity --- hookah --- overweight --- shisha --- abdominal obesity --- weight management --- treatment --- adolescents --- arterial stiffness --- birth weight --- body-size trajectories --- cardio-metabolic health --- children --- growth --- intima-media thickness --- blood pressure --- acute rheumatic fever --- rheumatic heart diseases --- MT-CYB --- mutation --- Senegal --- hypercholesterolemia --- cluster of differentiation 14 --- rs2569190A&gt --- G --- single nucleotide polymorphisms --- association analysis

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The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.

Research & information: general --- Biology, life sciences --- Genetics (non-medical) --- autism spectrum disorders (ASD) --- cancer --- overlapping genes and gene profiling --- super-pathways --- phenotypes and diseases --- molecular functions and processes --- 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome --- imprinting --- parent-of-origin effects --- phenotype-genotype correlation --- autism --- developmental delays --- motor delays --- microbiome --- gut --- ProSAP2 --- Phelan McDermid Syndrome --- gut–brain interaction --- leaky gut --- IL-6 --- SHANK --- collapsin response mediator protein 4 --- autism spectrum disorder --- neurodevelopmental disorder --- whole-exome sequencing --- animal model --- sex different phenotypes --- 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome) --- NIPA1 --- NIPA2 --- CYFIP1 --- TUBGCP5 genes --- Prader–Willi and Angelman syndromes --- magnesium transporters and supplementation --- potential treatment options --- intellectual disability --- AMPA receptors --- NMDA receptors --- guanine nucleotide exchange factor --- synaptic plasticity --- Autism spectrum disorder --- ASD --- Obesity --- Overweight --- Body mass index --- BMI --- autism candidate genes --- synaptotagmin-like protein 4 (SYTL4) --- transmembrane protein 187 (TMEM187) --- SYTL4-protein structure --- STRING-protein-protein interaction --- expression profile --- microRNA- interactions --- autism spectrum disorders --- biological networks --- genomics --- multi-omics --- network diffusion --- data integration --- genetics --- quantitative traits --- stratification by trait severity --- heterogeneity reduction --- case-control association analysis --- fragile X syndrome --- RNA toxicity --- DNA methylation --- mosaicism --- pediatrics --- MS-QMA --- AmplideX --- cytokine --- monocyte --- β-glucan --- T cell cytokine --- trained immunity --- maternal immune activation --- epigenetics --- mice --- postnatal VPA injection --- SAM --- gene expression --- nanostring --- autism spectrum disorders (ASD) --- cancer --- overlapping genes and gene profiling --- super-pathways --- phenotypes and diseases --- molecular functions and processes --- 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome --- imprinting --- parent-of-origin effects --- phenotype-genotype correlation --- autism --- developmental delays --- motor delays --- microbiome --- gut --- ProSAP2 --- Phelan McDermid Syndrome --- gut–brain interaction --- leaky gut --- IL-6 --- SHANK --- collapsin response mediator protein 4 --- autism spectrum disorder --- neurodevelopmental disorder --- whole-exome sequencing --- animal model --- sex different phenotypes --- 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome) --- NIPA1 --- NIPA2 --- CYFIP1 --- TUBGCP5 genes --- Prader–Willi and Angelman syndromes --- magnesium transporters and supplementation --- potential treatment options --- intellectual disability --- AMPA receptors --- NMDA receptors --- guanine nucleotide exchange factor --- synaptic plasticity --- Autism spectrum disorder --- ASD --- Obesity --- Overweight --- Body mass index --- BMI --- autism candidate genes --- synaptotagmin-like protein 4 (SYTL4) --- transmembrane protein 187 (TMEM187) --- SYTL4-protein structure --- STRING-protein-protein interaction --- expression profile --- microRNA- interactions --- autism spectrum disorders --- biological networks --- genomics --- multi-omics --- network diffusion --- data integration --- genetics --- quantitative traits --- stratification by trait severity --- heterogeneity reduction --- case-control association analysis --- fragile X syndrome --- RNA toxicity --- DNA methylation --- mosaicism --- pediatrics --- MS-QMA --- AmplideX --- cytokine --- monocyte --- β-glucan --- T cell cytokine --- trained immunity --- maternal immune activation --- epigenetics --- mice --- postnatal VPA injection --- SAM --- gene expression --- nanostring

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The evolution of knowledge management theory and the special emphasis on human and social capital sets new challenges for knowledge-driven and technology-enabled innovation. Emerging technologies including big data and analytics have significant implications for sustainability, policy making, and competitiveness. This edited volume promotes scientific research into the potential contributions knowledge management can make to the new era of innovation and social inclusive economic growth. We are grateful to all the contributors of this edition for their intellectual work. The organization of the relevant debate is aligned around three pillars: SECTION A. DATA, KNOWLEDGE, HUMAN AND SOCIAL CAPITAL FOR INNOVATION: We elaborate on the new era of knowledge types and the emerging forms of social capital and their impact on technology-driven innovation. Topics include: Social Networks; Smart Education; Social Capital; Corporate Innovation; Disruptive Innovation; Knowledge integration; Enhanced Decision-Making. SECTION B. KNOWLEDGE MANAGEMENT & BIG DATA ENABLED INNOVATION: In this section, knowledge management and big data applications and systems are presented. Selective topic include: Crowdsourcing Analysis; Natural Language Processing; Data Governance; Knowledge Extraction; Ontology Design Semantic Modeling SECTION C. SUSTAINABLE DEVELOPMENT: In the section, the debate on the impact of knowledge management and big data research to sustainability is promoted with integrative discussion of complementary social and technological factors including: Big Social Networks on Sustainable Economic Development; Business Intelligence

knowledge assets --- social capital --- MTurk --- hybrid neural networks --- education --- knowledge specificity --- innovation capability --- taxonomy --- mechanical patent classification --- patent analysis --- universities --- knowledge mapping --- patent association analysis --- co-citation network --- human capital investment --- cloud data governance --- risk perception --- project-based organization --- corporate sustainability --- crowdsourcing --- Big Data --- smart education --- international technological collaboration --- social network analysis --- big data analysis --- collaboration network --- six sigma --- conceptual maturity model --- NLP --- RDF --- IC manufacturing --- Jordan --- innovation --- human capital --- visualizing --- holistic --- systematic review --- open data --- personalized business mode --- process innovation capability --- sustainable competitive advantage --- knowledge embeddedness --- quality orientation of employees-QOE --- multi-dimensional data model --- knowledge sharing --- keywords analysis --- emerging trends --- intellectual structure --- administrative procedure --- business intelligence --- disruptive innovation --- citizen-scientist --- bibliometric --- communication --- big data --- climate change --- big data environment --- text structure --- P-PLAN --- knowledge creation --- top management team --- sustainability --- transformational training programs-TTP --- sustainable development --- text feature extraction --- technological information --- knowledge creation process --- data governance --- key performance indicators --- technology-enhanced learning process --- PROV-O --- Twitter --- training --- knowledge management --- absorptive capacity --- provenance --- leadership --- strategic decision-making --- text mining --- cloud computing --- technology acceptance model --- linked data --- social media --- structural equation model --- internal social networks --- data analysis --- social networks --- product innovation capability --- innovation performance --- heterogeneous architectures --- administrative file --- new ventures --- competitive advantage --- user acceptance --- employee loyalty-EL --- ontology design

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Overall, the 19 contributions in this Special Issue “Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions” discuss the various aspects of salt stress responses in plants. It also discusses various mechanisms and approaches to conferring salt tolerance on plants. These types of research studies provide further directions in the development of crop plants for the saline environment in the era of climate change.

CPA gene family --- RsNHX1 --- over-expression --- virus-induced gene silence --- salt resistance --- radish --- 14-3-3 gene family --- Triticum aestivum L. --- bioinformatics analysis --- salt tolerance --- protein-protein interactions --- Populus simonii × P. nigra --- PsnNAC036 --- transcription factor --- salt stress --- HT tolerance --- ion transport --- osmotic homeostasis --- hormone mediation --- cell wall regulation --- salt adaptation --- proteomics --- microtubules --- tubulin --- phenolic metabolites --- lemon balm --- chlorophyll fluorescence --- medicinal plants --- secondary metabolites --- abiotic elicitors --- salinity --- betaine aldehyde dehydrogenase 1 (BADH1) --- domestication --- cultivated rice --- wild rice --- Hordeum vulgare L. --- RNA-seq analysis --- differentially expressed genes --- tolerance --- candidate genes --- C3–CAM intermediate --- common ice plant --- Mesembryanthemum crystallinum --- osmotic stress --- abiotic stress --- antioxidant defense --- climate change --- hydrogen peroxide --- lipid peroxidation --- oxidative stress --- phytohormones --- stress signaling --- mulberry --- TMT proteomics --- phenylpropanoid metabolism --- apoplast --- functional screening --- Hordeum vulgare --- seedling --- halophyte species --- NADPH oxidases --- NOX --- respiratory burst oxidase homolog RBOH gene expression --- saline adaptations --- C2H2 zinc finger protein --- heterologous expression --- Millettia pinnata --- thaumatin-like proteins (TLPs) --- bolTLP1 --- broccoli --- drought stress --- antioxidants --- carbohydrates --- carotenoids --- xanthophyll cycle --- osmoprotectants --- ROS-scavengers --- α-/γ-tocopherols --- quantitative trait locus (QTL) --- association analysis --- marker-assisted selection (MAS) --- rice (Oryza sativa L.) --- hydroxyindole-O-methyltransferase gene --- melatonin --- ROS --- ABA --- ion homeostasis --- amino acids --- Malus domestica --- calcium --- calcineurin B-like proteins --- Na+ accumulation --- n/a --- C3-CAM intermediate

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Aquaculture is an important economic activity for food production all around the world that has experienced an exponential growth during the last few decades. However, several weaknesses and bottlenecks still need to be addressed in order to improve the aquaculture productive system. The recent fast development of the omics technologies has provided scientists with meaningful tools to elucidate the molecular basis of their research interests. This reprint compiles different works about the use of transcriptomics and genomics technologies in different aspects of the aquaculture research, such as immunity, stress response, development, sexual dimorphism, among others, in a variety of fish and shellfish, and even in turtles. Different transcriptome (mRNAs and non-coding RNAs (ncRNAs)), genome (Single Nucleotide Polymorphisms (SNPs)), and metatranscriptome analyses were conducted to unravel those different aspects of interest.

Research & information: general --- Biology, life sciences --- Fisheries & related industries --- RNA-Seq --- lncRNAs --- Dicentrarchus labrax --- viral infection --- nodavirus --- immune response --- fish --- T lymphocytes --- infection --- malnutrition --- inflammation --- aquaculture --- histopathology --- immunohistochemistry --- enteromyxosis --- Philasterides dicentrarchi --- turbot --- transcriptomics --- Chinese mitten crab --- Eriocheir sinensis --- transportome --- transporters --- salinity --- osmoregulation --- transcriptome --- meta-analysis --- gills --- short pentraxins --- c-reactive protein --- zebrafish --- transcript expression --- antiviral --- SVCV --- rag1 mutants --- skin --- mucosal immunity --- hypoxia --- hypo-metabolic state --- growth --- swimming performance --- metabolic landmarks --- muscle transcriptome --- glycolysis --- lipid metabolism --- protein turnover --- gilthead sea bream --- hepatopancreas necrosis disease --- metatranscriptomics sequencing --- hepatopancreatic flora --- teleost --- B cells --- single cell transcriptomics --- immunoglobulins --- immune markers --- transcription factors --- long non-coding RNAs --- hepatic transcript expression --- salmon --- microarray --- omega-6/omega-3 ratio --- nutrigenomics --- fatty acids --- liver --- muscle --- Misgurnus anguillicaudatus --- sexual size dimorphism --- polyploid size dimorphism --- comparative transcriptome --- gene expression --- edible red sea urchin --- Loxechinus albus --- RNA-seq --- reference transcriptome --- Chinese soft-shelled turtle --- Aeromonas hydrophila --- hemorrhagic sepsis --- molecular immunopathogenesis --- tripartite motif proteins --- B30.2 domain --- antiviral immunity --- Ctenopharyngodon idella --- grass carp reovirus --- metamorphosis --- brain --- RNA --- sequencing --- intermuscular bone --- development --- Megalobrama amblycephala --- Oreochromis niloticus --- histological structure --- Atlantic salmon --- smoltification --- genome --- mRNAs --- miRNAs --- sox family genes --- Pelodiscus sinensis --- estradiol --- pseudo-female --- sex-related --- heterosis --- heterobeltiosis --- environment --- transgressive genes --- conserved miRNA --- high-throughput sequencing --- lumpfish --- novel miRNA --- RT-qPCR --- heat shock protein --- co-chaperon network --- salinity-alkalinity adaptation --- molecular evolution --- Lateolabrax maculatus --- genomics --- stress response --- HPI-axis --- neuroendocrine-immune interaction --- common carp --- poly-unsaturated fatty acid --- fatty acid elongase --- association study --- genomic selection --- bulked segregant analysis --- SNP --- association analysis --- joint effect --- seawater adaptation --- microRNAs --- small-RNA sequencing --- microarray transcriptome --- European seabass --- chronic inflammation --- opioid receptors --- immune status --- whole-transcriptome sequencing --- sex differentiation --- non-coding RNAs --- ceRNA --- red cusk-eel --- thermal stress --- liver transcriptome --- oxidative damage --- protein folding --- hepatic enzymes --- n/a