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Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.

Medicine --- amine nucleophiles --- alkynoic acids --- cascade reaction --- gold catalysis --- fused N-heterocycles --- solid-phase synthesis --- ketone --- traceless synthesis --- natural products --- enol ethers --- photocatalysis --- photoredox --- visible-light-induced catalysis --- photoredox cyclization --- organic dyes --- heterocycles --- dihydrocoumarins --- synthesis --- 3-trifluoroacetyl coumarins --- phenols --- antifungal activities --- terpyridines --- 3,2′:6′,3″-terpyridine --- cyclohexanol derivative --- condensation --- heterocyclic --- 1,2,3-triazol --- triazolylmethyl phosphinate --- triazolylmethyl phosphate --- copper-catalyzed azide-alkyne cycloaddition --- click reaction --- azides --- cinnolines --- triazoles --- CuAAC --- alkynes --- cycloalkynes --- Richter cyclization --- Suzuki coupling --- fluorescence --- cytotoxicity --- coumarin --- pyrazolo[3,4-b]pyridine --- silica sulfuric acid --- 2H-pyran --- valence isomerism --- 1-oxa-triene --- dienone --- oxa-electrocyclization --- Knoevenagel --- propargyl Claisen --- cycloisomerization --- asymmetric dimeric β-carboline --- acylhydrazone group --- cytotoxic --- antitumor --- structure–activity relationship --- γ-lactam --- pyrrolidones --- multicomponent reactions --- organocatalysis --- pyridine --- CF3CO-acetylenes --- 1,3-oxazines --- fluorinated heterocycles --- saturated oxygen heterocycles --- cyclic ethers --- total synthesis --- multicomponent reaction --- α-halohydrazones --- Staudinger reaction --- aza-Wittig --- 1H-imidazole-2(3H)-thione --- 2H-imidazo[2,1-b][1,3,4]thiadiazine --- purine --- nucleobase --- aromatic substitution --- arylation --- fluoroalcohol --- α-chloroglycinates --- 5-acylamino-1,3-thiazoles --- Hantzsch reaction --- TMSBr --- propargylic alcohols --- cascade cyclization --- 4-bromo quinolines --- synthesis of benzofurans --- intra-molecular approach --- inter-molecular approach --- n/a --- 3,2':6',3"-terpyridine --- structure-activity relationship

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A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds. Fully characterized inorganic and organic molecules including X-ray crystallographic analysis. Cyclization reactions, reactivity of aromatic compounds and improved synthetic methodologies of important intermediate compounds.

heterocycle --- piperazine --- pyrimidine --- DABCO --- nucleophilic displacement --- chlorination --- [1,3]-H shift --- aza-Michael addition --- DFT calculations --- dimethyl acetylenedicarboxylate --- isoxazolo[3,4-b]quinolin-3(1H)-one --- pyrazolines --- curcuminoids --- nitrogen heterocycles --- cytotoxic --- DNA binding --- MDR reversal --- oxygen-nitrogen heterocycles --- 11a,12-dihydrobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine --- disulfur dichloride --- o-aminophenol --- condensation --- 4-anilino-quin(az)olines --- hinge binder --- conformational flexibility --- kinase inhibitor design --- imine --- Schiff base --- X-ray crystallographic analysis --- Cu(II) complex --- gamma-amino acid --- ruthenium --- carbonyl complex --- azopyridine --- anion radical --- electronic structure --- magnetic properties --- chalcogenophene --- heterocycles --- ligands --- pyridine derivatives --- thiophene derivatives --- aminocyclopentitol --- bicyclic aziridine --- water chemistry --- nucleophilic substitution --- homopiperazine --- X-ray structure --- C–C bond length --- 15N-NMR --- catechol --- alkyne --- thiol-alkyne click reaction --- domino reactions --- bromination --- intramolecular SN displacement --- carbocyclic hydantoins --- N-1 substituted hydantoin --- spiro hydantoins --- imidazolidine-2,4-diones --- stereochemistry --- NMR --- HRMS --- GIAO --- ring closing --- Au-nanoparticles --- NaBH4 --- amino-substituted fused oxazolocoumarin --- fused oxazolocoumarins --- chemoselective reduction --- o-hydroxynitrocoumarins --- benzimidazole --- nucleophilic aromatic substitution --- thiosemicarbazone --- n/a --- C-C bond length

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A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds. Fully characterized inorganic and organic molecules including X-ray crystallographic analysis. Cyclization reactions, reactivity of aromatic compounds and improved synthetic methodologies of important intermediate compounds.

Research & information: general --- heterocycle --- piperazine --- pyrimidine --- DABCO --- nucleophilic displacement --- chlorination --- [1,3]-H shift --- aza-Michael addition --- DFT calculations --- dimethyl acetylenedicarboxylate --- isoxazolo[3,4-b]quinolin-3(1H)-one --- pyrazolines --- curcuminoids --- nitrogen heterocycles --- cytotoxic --- DNA binding --- MDR reversal --- oxygen-nitrogen heterocycles --- 11a,12-dihydrobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine --- disulfur dichloride --- o-aminophenol --- condensation --- 4-anilino-quin(az)olines --- hinge binder --- conformational flexibility --- kinase inhibitor design --- imine --- Schiff base --- X-ray crystallographic analysis --- Cu(II) complex --- gamma-amino acid --- ruthenium --- carbonyl complex --- azopyridine --- anion radical --- electronic structure --- magnetic properties --- chalcogenophene --- heterocycles --- ligands --- pyridine derivatives --- thiophene derivatives --- aminocyclopentitol --- bicyclic aziridine --- water chemistry --- nucleophilic substitution --- homopiperazine --- X-ray structure --- C-C bond length --- 15N-NMR --- catechol --- alkyne --- thiol-alkyne click reaction --- domino reactions --- bromination --- intramolecular SN displacement --- carbocyclic hydantoins --- N-1 substituted hydantoin --- spiro hydantoins --- imidazolidine-2,4-diones --- stereochemistry --- NMR --- HRMS --- GIAO --- ring closing --- Au-nanoparticles --- NaBH4 --- amino-substituted fused oxazolocoumarin --- fused oxazolocoumarins --- chemoselective reduction --- o-hydroxynitrocoumarins --- benzimidazole --- nucleophilic aromatic substitution --- thiosemicarbazone