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This is collection of original and review articles selected in recognition of the contribution of Instituto Butantan to the field of toxinology and its continued and relevant role in this field in the 120 years since its foundation. Congratulations to the Butantan Institute, its house scientists, and collaborators on its 120th anniversary!

Research & information: general --- Biology, life sciences --- mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial-mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins --- mass spectrometry --- proteome --- snake venom --- Bothrops jararaca --- breast cancer --- HF3 --- human plasma --- proteolysis --- snake venom metalloproteinase --- Bothrops atrox --- blister --- local damage --- DAMPs --- antivenom --- snakebite --- Bothrops --- metalloproteases --- inflammation --- microcirculation --- adhesion molecules --- leukocyte-endothelium interactions --- individual variability --- venom heterogeneity --- STEC --- Stx2 --- antibody fragment --- monoclonal antibody --- neurodegenerative disease --- neurodegeneration --- IL-17 --- glial cells --- crotoxin --- epithelial-mesenchymal transition --- spheroid model --- tumor stroma --- Lonomia --- envenoming --- innovation --- Tityus serrulatus --- venom components --- hypotensins --- NEP inhibition --- cytokines --- toxins --- venoms --- skin secretion --- drug discovery --- scorpion accidents --- lactation --- maternal care --- seizure threshold --- leech --- Haementeria vizottoi --- cysteine proteases inhibitor --- recombinant cystatin --- cathepsin L --- Cryptops iheringi --- centipede --- venom --- toxin --- transcriptome --- recombinant protein --- venomics --- chilopoda --- oral tolerance --- ELISA --- Bothrops phospholipases A2 --- lipid mediators --- signaling pathways --- fish venoms --- cytolysins --- multifunctionality --- pore formation --- Bitis arietans venom (BaV) --- Kn-Ba --- cytokines and chemokines --- PGE2 --- THP-1 macrophages --- analgesic peptide --- protein kinase C --- hyperalgesia --- cell-signaling --- Hyalomma dromedarii --- salivary glands --- serpin --- anticoagulants --- thrombin inhibitor --- β-defensins --- snakes --- antimicrobial activity --- bioisosterism --- peptides --- Thalassophryne --- nattectin --- reverse-phase HPLC --- MALDI-ToF --- hemagglutinating activity --- antibacterial activity --- toxinology --- animal toxins