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book (4)


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2022 (3)

2019 (1)

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Book
Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges
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ISBN: 3039217070 3039217062 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.

Keywords

bleomycin --- n/a --- regeneration --- antitumor efficacy --- lung cancer --- SOX2 --- leiomyosarcoma --- lung cancer (LC) --- nanoparticles --- cytokines --- hepatocellular carcinoma --- metabolic reprogramming --- hepatic stellate cells --- angiogenesis --- transforming growth factor-? --- anaplastic lymphoma kinase --- idiopathic pulmonary fibrosis --- growth factor --- pathogenesis --- cancer-associated fibroblasts --- fibrosis --- lipopolysaccharide --- DHA --- lncRNA --- SREBP-1 --- YAP --- protein S --- non-small cell lung cancer (NSCLC) --- omega-3 fatty acid --- inflammation --- metastasis --- clinical symptoms --- miRNA --- smooth muscle tumor of uncertain malignant potential --- Wnt --- interstitial fluid pressure --- heterogeneity --- hepatocytes --- myometrium --- tumor necrosis factor ? --- tumor --- tumor microenvironment --- extracellular matrix --- TAZ --- carcinogenesis --- cystic formation --- pulmonary fibrosis --- HBV --- cytokine --- genetic instability --- diagnosis --- EMT --- crizotinib --- Hippo pathway --- GPR120 --- marker --- HCV --- non-alcoholic steatohepatitis --- pathology --- common pathways --- apoptosis --- type I collagen --- GPR40 --- acute lung injury --- uterine fibroid --- renal injury --- pathophysiology --- reactive oxygen species --- immunohistochemistry --- SMAD --- butylidenephthalide --- leiomyoma --- cirrhosis --- Erk1/2 --- targeted therapy --- TGF-? --- mechanotransduction --- therapy --- breast cancer --- hepatocellular carcinoma (HCC) --- hepatic stellate cells (HSCs) --- idiopathic pulmonary fibrosis (IPF) --- cancer-associated fibroblasts (CAFs) --- cancer --- signal pathway --- tumor stiffness


Book
Advanced Polymers for Biomedical Applications
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

Keywords

Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine


Book
Advanced Polymers for Biomedical Applications
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

Keywords

biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine


Book
Advanced Polymers for Biomedical Applications
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

Keywords

Technology: general issues --- Biotechnology --- biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine

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