Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Medical microbiology & virology --- Microbiology (non-medical) --- non-ribosomal peptide --- bacterial toxin --- anticancer activity --- antimicrobial activity --- antibiotic --- bacteriocin --- bacterial enzyme --- non-ribosomal peptide --- bacterial toxin --- anticancer activity --- antimicrobial activity --- antibiotic --- bacteriocin --- bacterial enzyme

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.

Medicine --- saffron --- affron® --- depression --- anxiety --- antioxidant --- crocins --- glucose --- β-pancreatic cells --- insulin --- pck1 --- neuroprotective activity --- P2X7 receptor --- fraction --- flumazenil --- rat --- Crocus sativus --- cancer --- anticancer activity --- chemoprevention --- clinical trials --- patents --- anesthetic ketamine --- memory --- Crocus sativus L. --- schizophrenia --- crocetin --- pubertal testis --- X-rays --- radiotherapy --- fertility preservation --- SIRT1 --- HuR --- oxidative stress --- autophagy --- crocin --- picrocrocin --- safranal --- dietary supplement --- nutraceutical --- Crocus sativus L. (Iridaceae) --- reversed-phase UPLC --- metabolomics --- HR MS --- inflammatory bowel disease --- gut microbiota --- colitis --- cytokines --- colorectal cancer --- HCT116 --- MLH1 --- MSH3 --- DNA damage and repair --- apoptosis --- saffron --- affron® --- depression --- anxiety --- antioxidant --- crocins --- glucose --- β-pancreatic cells --- insulin --- pck1 --- neuroprotective activity --- P2X7 receptor --- fraction --- flumazenil --- rat --- Crocus sativus --- cancer --- anticancer activity --- chemoprevention --- clinical trials --- patents --- anesthetic ketamine --- memory --- Crocus sativus L. --- schizophrenia --- crocetin --- pubertal testis --- X-rays --- radiotherapy --- fertility preservation --- SIRT1 --- HuR --- oxidative stress --- autophagy --- crocin --- picrocrocin --- safranal --- dietary supplement --- nutraceutical --- Crocus sativus L. (Iridaceae) --- reversed-phase UPLC --- metabolomics --- HR MS --- inflammatory bowel disease --- gut microbiota --- colitis --- cytokines --- colorectal cancer --- HCT116 --- MLH1 --- MSH3 --- DNA damage and repair --- apoptosis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.

Medicine --- saffron --- affron® --- depression --- anxiety --- antioxidant --- crocins --- glucose --- β-pancreatic cells --- insulin --- pck1 --- neuroprotective activity --- P2X7 receptor --- fraction --- flumazenil --- rat --- Crocus sativus --- cancer --- anticancer activity --- chemoprevention --- clinical trials --- patents --- anesthetic ketamine --- memory --- Crocus sativus L. --- schizophrenia --- crocetin --- pubertal testis --- X-rays --- radiotherapy --- fertility preservation --- SIRT1 --- HuR --- oxidative stress --- autophagy --- crocin --- picrocrocin --- safranal --- dietary supplement --- nutraceutical --- Crocus sativus L. (Iridaceae) --- reversed-phase UPLC --- metabolomics --- HR MS --- inflammatory bowel disease --- gut microbiota --- colitis --- cytokines --- colorectal cancer --- HCT116 --- MLH1 --- MSH3 --- DNA damage and repair --- apoptosis --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The search for bioactive secondary metabolites from marine organisms has been an active area of research since the 1950s. The distinct biodiversity of the marine environment has afforded a vast array of unique secondary metabolites, many of which possess potent biological activities. This Special Issue of Marine Drugs will highlight recent bioactive marine natural product studies conducted by southern hemisphere scientists on an array of marine organisms.

Sinularia --- Alcyoniidae --- anticancer activity --- lobane --- cembrane --- diterpene --- conotoxins --- ShK toxin --- ion channels --- docking --- molecular dynamics --- potential of mean force --- free energy perturbation --- bioactivity --- biosynthesis --- brominated secondary metabolites --- choline ester --- indole --- sea cucumber --- viscera --- saponins --- mass spectrometry --- MALDI --- ESI --- HPCPC --- triterpene glycosides --- structure elucidation --- bioactive compounds --- marine invertebrate --- Echinodermata --- holothurian --- Cnemidocarpa stolonifera --- taurine amide --- PC3 cell line --- immunofluorescence assay --- thiaplidiaquinone --- Aplidium --- ascidian --- thiazinoquinone --- apoptosis --- Jurkat --- cytotoxicity --- malaria --- farnesyltransferase --- synthesis --- thiaplakortone --- regioisomer --- tricyclic --- natural product scaffold --- X-ray --- crystal --- Plasmodium falciparum --- antiplasmodial --- cephalostatin --- mandelalide --- methicillin resistant Staphylococcus aureus --- MRSA PK --- bisindole alkaloids --- salternamide A (SA) --- HIF-1α --- PI3K/Akt/mTOR --- p42/p44 MAPK --- STAT3 --- cell death

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.

Research & information: general --- Chemistry --- fluorinated pyrazole aldehydes --- tyrosinase inhibition --- phosphodiesterase inhibition --- antibacterial activity --- molecular docking --- periodontitis --- SRP --- LDD --- gelcide --- cancer --- phytocomponents --- Tiospora cardifolia --- silica --- silver oxynitrate --- stability --- core-shell --- antibiofilm --- antimicrobial --- sesquiterpene --- inflammatory pathologies --- nutraceuticals --- triclosan --- surgical site infection --- suture --- abdominal surgery --- cost-analysis --- budget impact analysis --- spirooxindole --- 1,3-dipolar cycloaddition --- eco-friendly chemistry --- ROCS --- shape alignment --- lipophilicity --- anticancer activity --- sol-gel coating --- medical textiles --- antioxidant --- anti-inflammatory --- PEA derivative --- drug release --- imidazole --- antiproliferative --- antioxidant activities --- docking --- DPPH --- ABTS --- acetylcholinesterase --- xanthine oxidase --- pyrimidine-trione --- barbituric --- thiobarbituric --- urease inhibitors --- DFT --- N-benzylisatin-aryl hydrazones --- gefitinib --- A549 cell lines --- pomegranate --- Punica granatum L. --- pomegranate skin extract --- pomegranate fruit extract --- nutraceutical properties --- biological properties --- cladodes --- Opuntia --- antioxidants --- polyphenols --- SFE-CO2 --- rutin --- iso-quercitrin --- nicotiflorin --- narcissin --- fluorinated pyrazole aldehydes --- tyrosinase inhibition --- phosphodiesterase inhibition --- antibacterial activity --- molecular docking --- periodontitis --- SRP --- LDD --- gelcide --- cancer --- phytocomponents --- Tiospora cardifolia --- silica --- silver oxynitrate --- stability --- core-shell --- antibiofilm --- antimicrobial --- sesquiterpene --- inflammatory pathologies --- nutraceuticals --- triclosan --- surgical site infection --- suture --- abdominal surgery --- cost-analysis --- budget impact analysis --- spirooxindole --- 1,3-dipolar cycloaddition --- eco-friendly chemistry --- ROCS --- shape alignment --- lipophilicity --- anticancer activity --- sol-gel coating --- medical textiles --- antioxidant --- anti-inflammatory --- PEA derivative --- drug release --- imidazole --- antiproliferative --- antioxidant activities --- docking --- DPPH --- ABTS --- acetylcholinesterase --- xanthine oxidase --- pyrimidine-trione --- barbituric --- thiobarbituric --- urease inhibitors --- DFT --- N-benzylisatin-aryl hydrazones --- gefitinib --- A549 cell lines --- pomegranate --- Punica granatum L. --- pomegranate skin extract --- pomegranate fruit extract --- nutraceutical properties --- biological properties --- cladodes --- Opuntia --- antioxidants --- polyphenols --- SFE-CO2 --- rutin --- iso-quercitrin --- nicotiflorin --- narcissin