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Biology --- Free Radicals --- Medicine --- Oxidation-Reduction --- Oxidative Stress --- Peroxidases --- Free radicals (Chemistry) --- Oxidation, Physiological --- Radicaux libres (Chimie) --- Oxydation biologique --- Periodicals. --- periodicals. --- Pathophysiology --- Periodicals --- Physiopathologie --- Périodiques --- Biology. --- Free Radicals. --- Medicine. --- Oxidation-Reduction. --- Oxidative Stress. --- Peroxidases. --- Oxidation, Physiological. --- Pathophysiology. --- Health Sciences --- Life Sciences --- Pathology --- free radicals --- oxidative stress --- activated oxygen --- redox processes --- perioxidative processes --- Ovoperoxidase --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Redox --- Oxidation Reduction --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Radicals, Free --- Free Radical Scavengers --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Radicals (Chemistry) --- Free radical reactions --- Health Workforce --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative --- Free Radical --- Radical, Free

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This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.

Cytology --- Biology --- Health & Biological Sciences --- Toxicology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemicals --- Toxicology --- Life sciences. --- Apoptosis. --- Oxidative stress. --- Environmental health. --- Life Sciences. --- Oxidative Stress. --- Pharmacology/Toxicology. --- Environmental Health. --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Physiological effect --- Cytology. --- Environmental Medicine. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Toxicological Phenomena. --- Pharmacological Phenomena. --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Toxicologic Phenomena --- Toxicologic Phenomenon --- Toxicological Concepts --- Toxicological Phenomenon --- Concept, Toxicological --- Concepts, Toxicological --- Phenomena, Toxicologic --- Phenomena, Toxicological --- Phenomenon, Toxicologic --- Phenomenon, Toxicological --- Toxicological Concept --- Environmental quality --- Health --- Health ecology --- Public health --- Environmental engineering --- Health risk assessment --- Cell death --- Oxidation-reduction reaction --- Stress (Physiology) --- Health aspects --- Environmental aspects --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative

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Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges.

Tropical Eastern Pacific --- Zoanthus pulchellus --- critical illness --- zoanthamine --- SPR analysis --- dendritic cells --- endothelial cell death --- T cell differentiation --- seafood waste --- microalgae --- pyrogallol-phloroglucinol-6 --- NRLP3 --- THP-1 macrophages --- fucoxanthin --- photo-protection --- cytokine --- thromboxane --- Isochrysis galbana --- fish oil --- photoprotection --- functional ingredients --- rosmarinic acid --- MAPK --- marine invertebrates --- poor blood circulation --- anti-inflammatory activity --- eicosapentaenoic acid --- anti-oxidative --- macroalgae --- colon inflammation --- MGDG --- TLR4 --- 6-bieckol --- polyunsaturated fatty acid --- matrix metalloproteinases-9 (MMP-9) --- acute sickness behavior --- UVB --- eicosanoid --- clavulones --- carotenoids --- denervation --- polyunsaturated fatty acids --- skin --- epidermal hyperplasia --- Geodia barretti --- omega-3 --- parenteral nutrition --- inflammation --- ultraviolet B --- docosahexaenoic acid --- signal transducer and activator of transcription 3 (STAT3) --- anti-inflammatory --- zoantharia --- vascular smooth muscle cell proliferation and migration --- bioactive molecules --- polysaccharides --- lipopolysaccharide (LPS) --- glycolipids --- DSS colitis --- punaglandins --- marine nutraceuticals --- marine vertebrates --- phlorotannins --- acute lung injury (ALI) --- NF-?B --- diatoms --- interleukin (IL) --- inflammasome --- Frondanol --- Cucumaria frondosa --- prostaglandins --- Ecklonia cava --- 6-bromoindole --- NO inhibition --- surgery

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Carotenoids represent a large group of isoprenoid structures with many different structural characteristics and biological activities. They are the most important of the naturally occurring pigments and are responsible for the various colors of different fruits, vegetables, and plant parts. Marine carotenoids and their unique structures are responsible for the color of many fish, shellfish, and algae. However, while there have been many papers and reviews on carotenoids of terrestrial origin, there has been relatively little research conducted on the impact of marine carotenoids on human health. Recent research efforts have revealed that marine carotenoids have strong biological activity affecting human health and are candidates for nutraceuticals. This Topical Collection of Marine Drugs is dedicated to marine carotenoids, and will focus on the benefits of carotenoids for human beings. For a better understanding of the physiological effects of marine carotenoids, this collection should include the most recent developments in the presence, analysis, chemistry, and biochemistry of marine carotenoids.

Research & information: general --- Biology, life sciences --- fucoxanthin --- scopolamine --- acetylcholinesterase --- Alzheimer’s disease --- cognitive impairments --- mytiloxanthin --- anti-oxidative activity --- singlet oxygen --- hydroxyl radical --- lipid peroxidation --- astaxanthin production --- carotenoids --- genome-reduced Corynebacterium glutamicum --- systematic approach --- metabolic engineering --- marine microalgae --- seaweeds --- nonconventional extraction --- electrotechnologies --- pulsed electric field-assisted extraction --- supercritical fluid extraction --- green processing --- microwave-assisted extraction --- marine drugs --- Bangia fuscopurpurea --- red algae --- lycopene cyclase --- carotenoid --- metabolism --- astaxanthin --- Escherichia coli --- β-carotene ketolase --- β-carotene hydroxylase --- Haematococcus pluvialis --- PII signaling protein --- nitrogen starvation --- gene cloning --- mRNA expression --- microalgae --- anti-angiogenic --- cardioprotective activity --- anti-cancer --- anti-diabetic --- anti-inflammatory --- anti-obesity --- anti-oxidant --- beauty --- Phaeodactylum tricornutum --- spectrophotometry --- high through-put screening --- antioxidants --- bioactive compounds --- blue biotechnology --- marine microorganisms --- ozonolysis --- apo-fucoxanthinone --- Caco-2 --- antiproliferative effect --- Pyropia yezoensis --- α-cryptoxanthin --- zeinoxanthin --- lutein-5,6-epoxide --- antheraxanthin --- carotenoid synthesis pathway --- red seaweed --- human papillomavirus 16 (HPV16) --- astaxanthin (Asta) --- acrosome reaction --- cholera toxin subunit B (CTB) --- L1 protein --- cigarette smoke exposure --- p38 MAPK --- antioxidant inflammatory --- synaptic-associated plasticity --- comparative transcriptome analyses --- alcoholic liver disease --- bioinformatic analysis --- phytoene --- fluridone --- cosmeceuticals --- anti-obesity effect --- Phaeodactylum extract --- Coelastrum --- canthaxanthin --- lutein --- nanoemulsion --- sublingual delivery --- ascorbyl palmitate --- Franz cell --- alcoholic liver injury --- oxidative stress --- Nrf2 --- TLR4 --- chronic obstructive pulmonary disease --- nuclear factor erythroid 2-related factor 2 --- heme oxygenase-1 --- siphonaxanthin --- dehydro-metabolite --- white adipose tissue --- metabolic pathway in vivo --- stereochemistry --- Tigriopus --- copepod --- meso-zeaxanthin --- zeaxanthin --- reactive oxygen species --- immune system --- antioxidant --- antibiotics --- thermal stress --- disease --- halocynthiaxanthin --- intestinal absorption --- functional food --- apoptosis --- inflammation --- lipid metabolism --- high-fat diet

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Carotenoids represent a large group of isoprenoid structures with many different structural characteristics and biological activities. They are the most important of the naturally occurring pigments and are responsible for the various colors of different fruits, vegetables, and plant parts. Marine carotenoids and their unique structures are responsible for the color of many fish, shellfish, and algae. However, while there have been many papers and reviews on carotenoids of terrestrial origin, there has been relatively little research conducted on the impact of marine carotenoids on human health. Recent research efforts have revealed that marine carotenoids have strong biological activity affecting human health and are candidates for nutraceuticals. This Topical Collection of Marine Drugs is dedicated to marine carotenoids, and will focus on the benefits of carotenoids for human beings. For a better understanding of the physiological effects of marine carotenoids, this collection should include the most recent developments in the presence, analysis, chemistry, and biochemistry of marine carotenoids.

Research & information: general --- Biology, life sciences --- fucoxanthin --- scopolamine --- acetylcholinesterase --- Alzheimer’s disease --- cognitive impairments --- mytiloxanthin --- anti-oxidative activity --- singlet oxygen --- hydroxyl radical --- lipid peroxidation --- astaxanthin production --- carotenoids --- genome-reduced Corynebacterium glutamicum --- systematic approach --- metabolic engineering --- marine microalgae --- seaweeds --- nonconventional extraction --- electrotechnologies --- pulsed electric field-assisted extraction --- supercritical fluid extraction --- green processing --- microwave-assisted extraction --- marine drugs --- Bangia fuscopurpurea --- red algae --- lycopene cyclase --- carotenoid --- metabolism --- astaxanthin --- Escherichia coli --- β-carotene ketolase --- β-carotene hydroxylase --- Haematococcus pluvialis --- PII signaling protein --- nitrogen starvation --- gene cloning --- mRNA expression --- microalgae --- anti-angiogenic --- cardioprotective activity --- anti-cancer --- anti-diabetic --- anti-inflammatory --- anti-obesity --- anti-oxidant --- beauty --- Phaeodactylum tricornutum --- spectrophotometry --- high through-put screening --- antioxidants --- bioactive compounds --- blue biotechnology --- marine microorganisms --- ozonolysis --- apo-fucoxanthinone --- Caco-2 --- antiproliferative effect --- Pyropia yezoensis --- α-cryptoxanthin --- zeinoxanthin --- lutein-5,6-epoxide --- antheraxanthin --- carotenoid synthesis pathway --- red seaweed --- human papillomavirus 16 (HPV16) --- astaxanthin (Asta) --- acrosome reaction --- cholera toxin subunit B (CTB) --- L1 protein --- cigarette smoke exposure --- p38 MAPK --- antioxidant inflammatory --- synaptic-associated plasticity --- comparative transcriptome analyses --- alcoholic liver disease --- bioinformatic analysis --- phytoene --- fluridone --- cosmeceuticals --- anti-obesity effect --- Phaeodactylum extract --- Coelastrum --- canthaxanthin --- lutein --- nanoemulsion --- sublingual delivery --- ascorbyl palmitate --- Franz cell --- alcoholic liver injury --- oxidative stress --- Nrf2 --- TLR4 --- chronic obstructive pulmonary disease --- nuclear factor erythroid 2-related factor 2 --- heme oxygenase-1 --- siphonaxanthin --- dehydro-metabolite --- white adipose tissue --- metabolic pathway in vivo --- stereochemistry --- Tigriopus --- copepod --- meso-zeaxanthin --- zeaxanthin --- reactive oxygen species --- immune system --- antioxidant --- antibiotics --- thermal stress --- disease --- halocynthiaxanthin --- intestinal absorption --- functional food --- apoptosis --- inflammation --- lipid metabolism --- high-fat diet --- fucoxanthin --- scopolamine --- acetylcholinesterase --- Alzheimer’s disease --- cognitive impairments --- mytiloxanthin --- anti-oxidative activity --- singlet oxygen --- hydroxyl radical --- lipid peroxidation --- astaxanthin production --- carotenoids --- genome-reduced Corynebacterium glutamicum --- systematic approach --- metabolic engineering --- marine microalgae --- seaweeds --- nonconventional extraction --- electrotechnologies --- pulsed electric field-assisted extraction --- supercritical fluid extraction --- green processing --- microwave-assisted extraction --- marine drugs --- Bangia fuscopurpurea --- red algae --- lycopene cyclase --- carotenoid --- metabolism --- astaxanthin --- Escherichia coli --- β-carotene ketolase --- β-carotene hydroxylase --- Haematococcus pluvialis --- PII signaling protein --- nitrogen starvation --- gene cloning --- mRNA expression --- microalgae --- anti-angiogenic --- cardioprotective activity --- anti-cancer --- anti-diabetic --- anti-inflammatory --- anti-obesity --- anti-oxidant --- beauty --- Phaeodactylum tricornutum --- spectrophotometry --- high through-put screening --- antioxidants --- bioactive compounds --- blue biotechnology --- marine microorganisms --- ozonolysis --- apo-fucoxanthinone --- Caco-2 --- antiproliferative effect --- Pyropia yezoensis --- α-cryptoxanthin --- zeinoxanthin --- lutein-5,6-epoxide --- antheraxanthin --- carotenoid synthesis pathway --- red seaweed --- human papillomavirus 16 (HPV16) --- astaxanthin (Asta) --- acrosome reaction --- cholera toxin subunit B (CTB) --- L1 protein --- cigarette smoke exposure --- p38 MAPK --- antioxidant inflammatory --- synaptic-associated plasticity --- comparative transcriptome analyses --- alcoholic liver disease --- bioinformatic analysis --- phytoene --- fluridone --- cosmeceuticals --- anti-obesity effect --- Phaeodactylum extract --- Coelastrum --- canthaxanthin --- lutein --- nanoemulsion --- sublingual delivery --- ascorbyl palmitate --- Franz cell --- alcoholic liver injury --- oxidative stress --- Nrf2 --- TLR4 --- chronic obstructive pulmonary disease --- nuclear factor erythroid 2-related factor 2 --- heme oxygenase-1 --- siphonaxanthin --- dehydro-metabolite --- white adipose tissue --- metabolic pathway in vivo --- stereochemistry --- Tigriopus --- copepod --- meso-zeaxanthin --- zeaxanthin --- reactive oxygen species --- immune system --- antioxidant --- antibiotics --- thermal stress --- disease --- halocynthiaxanthin --- intestinal absorption --- functional food --- apoptosis --- inflammation --- lipid metabolism --- high-fat diet