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COM Compositae --- Artemisia --- Compositae --- anthelmintic --- artemisia caerulescens --- ethnobotany & economic botany --- experiments --- medicinal plants --- santonin --- treatment strategies

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Infectious & contagious diseases --- antimicrobial peptides --- phages --- anti-tumoral --- anti-virulence --- drug libraries --- antiprotozoal --- anthelmintic

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Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection.Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large.This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.

Communicable Diseases --- Public Health --- Health & Biological Sciences --- Schistosomiasis --- Schistosoma mansoni --- S japonicum --- neglected tropical diseases --- infection induced cancer --- Anthelmintic drugs --- S haematobium --- Blood fluke --- Vaccines --- Helminthiasis

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This volume contains monographs prepared at the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met in Rome, Italy, from 21 to 27 February 2002. The toxicological monographs in this volume summarize the safety data on the veterinary drug residues that were evaluated toxicologically by the Committee, which included two anthelminthic agents (doramectin and tiabendazole) and one antimicrobial agent (cefuroxime). The data summarized in these monographs served as the basis for the evaluations performed by the Committee. This volume and others in the WHO F

Feed additive residues -- Analysis -- Congresses. --- Feed additive residues -- Toxicology -- Congresses. --- Food contamination -- Analysis -- Congresses. --- Veterinary drug residues -- Analysis -- Congresses. --- Veterinary drug residues -- Toxicology -- Congresses. --- Antiparasitic Agents --- Body Burden --- Pharmaceutical Preparations --- Food Safety --- Cefotaxime --- Environmental Pollution --- Evaluation Studies as Topic --- Cephacetrile --- Investigative Techniques --- Public Health --- Anti-Infective Agents --- Chemicals and Drugs --- Therapeutic Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cephalosporins --- Environment and Public Health --- Health Care --- beta-Lactams --- Pharmacologic Actions --- Thiazines --- Lactams --- Sulfur Compounds --- Azabicyclo Compounds --- Chemical Actions and Uses --- Organic Chemicals --- Bicyclo Compounds, Heterocyclic --- Amides --- Bicyclo Compounds --- Bridged Compounds --- Polycyclic Compounds --- Cefuroxime --- Food Contamination --- Drug Evaluation --- Anthelmintics --- Drug Residues --- Veterinary Drugs --- Bridged Bicyclo Compounds, Heterocyclic --- Bridged Bicyclo Compounds --- Bridged-Ring Compounds --- Lactims --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Critique --- Evaluation --- Evaluation Indexes --- Evaluation Methodology --- Evaluation Report --- Evaluation Research --- Methodology, Evaluation --- Pre-Post Tests --- Qualitative Evaluation --- Quantitative Evaluation --- Theoretical Effectiveness --- Use-Effectiveness --- Critiques --- Effectiveness, Theoretical --- Evaluation Methodologies --- Evaluation Reports --- Evaluation, Qualitative --- Evaluation, Quantitative --- Evaluations --- Evaluations, Qualitative --- Evaluations, Quantitative --- Indexes, Evaluation --- Methodologies, Evaluation --- Pre Post Tests --- Pre-Post Test --- Qualitative Evaluations --- Quantitative Evaluations --- Report, Evaluation --- Reports, Evaluation --- Research, Evaluation --- Test, Pre-Post --- Tests, Pre-Post --- Use Effectiveness --- Pollution, Environmental --- Soil Pollution --- Pollution, Soil --- Aventis Brand of Cefotaxime Sodium --- Aventis Pharma Brand of Cefotaxime Sodium --- Benaxima --- Biosint --- Cefotaxim --- Cefotaxime Sodium --- Cefradil --- Cephotaxim --- Claforan --- Fotexina --- Fustery Brand of Cefotaxime Sodium --- Galen Brand of Cefotaxime Sodium --- HR-756 --- Hoechst Brand of Cefotaxime Sodium --- Kendrick --- Klaforan --- Liomont Brand of Cefotaxime Sodium --- Merck Brand of Cefotaxime Sodium --- Pisa Brand of Cefotaxime Sodium --- Primafen --- Ru-24756 --- Taporin --- Viken Brand of Cefotaxime Sodium --- HR 756 --- HR756 --- Ru 24756 --- Ru24756 --- Sodium, Cefotaxime --- Safety, Food --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Drugs --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Body Burdens --- Burden, Body --- Burdens, Body --- Antiparasitic Drugs --- Antiparasitics --- Parasiticides --- Agents, Antiparasitic --- Drugs, Antiparasitic --- Cephalosporanic Acids --- Antibiotics, Cephalosporin --- Acids, Cephalosporanic --- Cephalosporin Antibiotics --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Drug, Veterinary --- Pharmaceuticals, Veterinary --- Veterinary Drug --- Veterinary Pharmaceuticals --- Drugs, Veterinary --- Drug Residue --- Residue, Drug --- Residues, Drug --- Antihelmintics --- Vermifuges --- Drug Evaluation Studies --- Evaluation Studies, Drug --- Drug Evaluation Study --- Drug Evaluations --- Evaluation Study, Drug --- Evaluation, Drug --- Evaluations, Drug --- Studies, Drug Evaluation --- Study, Drug Evaluation --- Food Adulteration --- Adulteration, Food --- Adulterations, Food --- Contamination, Food --- Contaminations, Food --- Food Adulterations --- Food Contaminations --- Compounds, Polycyclic --- Chemicals, Organic --- Azabicyclo(1.1.0)Butanes --- Azabicyclo(2.2.2)Octanes --- Azabicyclo(3.3.1)Nonanes --- Azabicyclo(4.3.0)Nonanes --- Azabicyclo(5.2.2)Undecanes --- Compounds, Sulfur --- 4-Thia-1-Azabicyclo(3.2.0)Heptanes --- 4-Thia-1-Azabicyclo(4.2.0)Octanes --- beta Lactams --- C-36278-Ba --- Celospor --- Cephacetrile Sodium --- Cefacetrile --- C 36278 Ba --- C36278Ba --- Sodium, Cephacetrile --- Cephuroxime --- Ketocef --- Zinacef --- Bridged Ring Compounds --- Bicyclo Compounds, Bridged --- Bicyclic Heterocyclic Compounds --- Heterocyclic Bicyclo Compounds --- Heterocyclic Cpds, Bicyclic --- Bicyclic Heterocyclic Cpds --- Heterocyclic Compounds, Bicyclic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Environmental Pollutants --- Dietary Exposure --- Hazard Analysis and Critical Control Points --- Pharmacology --- Drug Dosage Calculations --- In Vivo Dosimetry --- Infection --- Parasites --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Helminthiasis --- Drugs, Investigational --- Hydrocarbons, Cyclic --- Pharmaceuticals --- Infections --- Sulfur Compound --- Compound, Sulfur --- Lactam --- Lactim --- beta-Lactam --- beta Lactam --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical --- Antiparasitic --- Cephalosporanic Acid --- Cephalosporin --- Cephalosporin Antibiotic --- Acid, Cephalosporanic --- Antibiotic, Cephalosporin --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Use, Therapeutic --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Anti Infective Agent --- Anti Microbial Agent --- Anthelmintic --- Antihelmintic --- Vermifuge --- Amide --- Organic Chemical --- Chemical, Organic --- analysis. --- veterinary. --- toxicity.