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Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membranes, over the years, the biennial “Annexin” conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into clinical settings. Research on annexins involves a global network of researchers and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan, and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes — the role of annexins in cellular organization and health and disease. The articles published in this Special Issue cover these two main themes discussed at the conference, offering a glimpse into some of the notable findings in the field of annexin biology

Research & information: general --- inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer --- inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer