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Anesthesiology --- Analgesia --- Anesthesia. --- Analgesics. --- Analgesia. --- Anesthesiology. --- Anaesthesiology --- Pain relief --- Analgesic Agents --- Analgesic Drugs --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Surgery --- Pain medicine --- Anesthesia --- Pain --- Anesthetics --- Analgesics --- Analgesic --- Agents, Antinociceptive
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Anesthesia & Analgesia includes peer-reviewed, original clinical and research articles, providing up-to-date information for practicing physicians, researchers, and allied medical personnel in anesthesiology and related fields.
Anesthesiology --- Anesthésiologie --- Periodicals --- Périodiques --- Anesthesia. --- Anesthesiology. --- Analgesia. --- Analgesics. --- Health Sciences --- General and Others --- Surgery --- Health Sciences. --- General and Others. --- Anesthésiologie --- Périodiques --- EJMEDEC EPUB-ALPHA-A EPUB-PER-FT MDANESTH OVID-E --- Analgesic Agents --- Analgesic Drugs --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Analgesias --- Anaesthesiology --- Analgesia --- Anesthesia --- Anesthetics --- Pain --- Analgesic --- Agents, Antinociceptive --- Anesthesiology - Periodicals --- Anesthésie. --- Anesthésiologie. --- Analgésie. --- Analgésiques.
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Pain --- Analgesics --- Analgesics. --- Pain. --- Anesthesia. --- Aches --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Analgesia --- Suffering --- Analgetics --- Anodynes --- Pain-killing drugs --- Pain relievers --- Painkillers --- Central nervous system depressants --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Pain Insensitivity, Congenital --- Hyperalgesia --- Palliative Care --- Anesthetics --- Analgesic Agents --- Analgesic Drugs --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Analgesic --- Agents, Antinociceptive
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Pain --- Analgesia --- Palliative treatment --- Analgesics --- Palliative Care. --- Treatment --- Therapeutic use --- drug therapy. --- prevention & control. --- therapeutic use. --- Palliative Care --- drug therapy --- prevention & control --- therapeutic use --- Analgesic Agents --- Analgesic Drugs --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Palliative Surgery --- Palliative Therapy --- Surgery, Palliative --- Therapy, Palliative --- Palliative Treatment --- Care, Palliative --- Palliative Treatments --- Treatment, Palliative --- Treatments, Palliative --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Analgetics --- Pain-killing drugs --- Pain relievers --- Painkillers --- Palliation (Medical care) --- Palliative care --- Palliative medicine --- Pain relief --- Analgesia. --- Palliative treatment. --- Treatment. --- Pain management --- Therapeutics --- Pain medicine --- Anesthesia --- Terminal Care --- Hospice and Palliative Care Nursing --- Palliative Medicine --- Pain Insensitivity, Congenital --- Hyperalgesia --- Anesthetics --- Central nervous system depressants --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Suffering --- Palliative Supportive Care --- Supportive Care, Palliative --- Analgesic --- Agents, Antinociceptive
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Carprofen inhibits certain pro-inflammatory genes and stimulates the in vitro production of glycosaminoglycans. However, it has chondrotoxicity that depends on its intra-articular concentration. Hyaluronic acid increases intra-articular viscosity and has anti-inflammatory and immunomodulatory effects. It preserves arthritic chondrocytes without affecting healthy ones. Intra-articular injection of hyaluronic acid is more effective at reducing pain and lameness than carprofen, although guidelines on viscosupplementation are unclear. Nonetheless, carprofen remains preferred for treating osteoarthritis due to its rare side effects and analgesic efficacy. The administration of intra-articular hyaluronic acid requires anesthesia for each injection and is not commercially available for dogs in Belgium, although the therapeutic cascade can be applied. In conclusion, while both treatments alleviate osteoarthritis pain, it is important to consider their respective advantages and disadvantages.
Carprofen --- osteoarthritis --- pharmacodynamic --- analgesic --- cartilage --- chondrocyte --- chondrotoxicity --- mechanism --- pain --- lameness --- hyaluronic --- acid --- carprofène --- arthrose --- pharmacodynamie --- analgésie --- cartilage --- chondrocyte --- chondrotoxicité --- mécanisme --- douleur --- boiterie --- hyaluronique --- acide --- Sciences du vivant > Médecine vétérinaire & santé animale
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Analgesia --- Pain --- Analgesics --- Drug Design. --- Analgesia. --- Analgesics. --- Chemotherapy --- therapeutic use. --- drug therapy. --- prevention & control. --- Chemotherapy. --- Drug Design --- therapeutic use --- drug therapy --- prevention & control --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Analgesic Agents --- Analgesic Drugs --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Drugs, Analgesic --- Pain relief --- Analgetics --- Pain-killing drugs --- Pain relievers --- Painkillers --- Pain Insensitivity, Congenital --- Hyperalgesia --- Palliative Care --- Anesthetics --- Pain medicine --- Anesthesia --- Central nervous system depressants --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Suffering --- Computer-Aided Drug Design --- Computerized Drug Design --- Pharmaceutical Design --- Computer Aided Drug Design --- Computer-Aided Drug Designs --- Computerized Drug Designs --- Design, Computer-Aided Drug --- Design, Computerized Drug --- Design, Pharmaceutical --- Designs, Computer-Aided Drug --- Designs, Computerized Drug --- Designs, Pharmaceutical --- Drug Design, Computer-Aided --- Drug Design, Computerized --- Drug Designs, Computer-Aided --- Drug Designs, Computerized --- Pharmaceutical Designs --- Analgesic --- Agents, Antinociceptive
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Anesthesia --- Critical care medicine --- Pain --- Anesthesia. --- Analgesia. --- Pain Management. --- Critical care medicine. --- Treatment --- Treatment. --- Health Sciences --- Anesthesiology --- Clinical Medicine --- Emergency Medicine and Critical Care --- Neurology --- Surgery --- Aches --- Anaesthesia --- Pain management --- Intensive care --- Intensive medicine --- Management, Pain --- Managements, Pain --- Pain Managements --- Analgesias --- therapy --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Analgesia --- Suffering --- Pain medicine --- Medicine --- Emergency medicine --- Intensive care units --- Chronic Disease --- Anesthetics --- anesthesia. --- analgesia. --- pain relief --- therapeutics --- analgesic effect --- analgesics --- anesthesia --- animal use refinement --- pain --- anaesthesia --- anesthesia reversal --- depth of anesthesia --- electronarcosis --- preanesthetic medication --- analgesia --- anesthetics --- muscle relaxants --- Pain Management
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Animal husbandry --- Anesthesia and Analgesia --- Sensory System Agents --- Neurologic Manifestations --- Sensation --- Central Nervous System Agents --- Signs and Symptoms --- Nervous System Physiological Processes --- Peripheral Nervous System Agents --- Psychophysiology --- Pathological Conditions, Signs and Symptoms --- Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutic Uses --- Physiological Effects of Drugs --- Diseases --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Pharmacologic Actions --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Actions and Uses --- Psychiatry and Psychology --- Phenomena and Processes --- Chemicals and Drugs --- Analgesics --- Analgesia --- Pain --- Health & Biological Sciences --- Veterinary Medicine --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Pain Insensitivity, Congenital --- Hyperalgesia --- Palliative Care --- Analgesias --- Analgesic Agents --- Analgesic Drugs --- Analgesic --- Anodynes --- Antinociceptive Agents --- Agents, Analgesic --- Agents, Antinociceptive --- Drugs, Analgesic --- Anesthetics --- Peripheral Nervous System Drugs --- Peripheral Nervous System Effect --- Peripheral Nervous System Effects --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Drug Effects on Physiology --- Drug Physiological Effects --- Effects, Drug Physiological --- Physiological Effects, Drug --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Symptoms and General Pathology --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Symptoms and Signs --- Central Nervous System Drugs --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Sensory System Drugs --- Agents, Sensory System --- Drugs, Sensory System --- System Agents, Sensory --- System Drugs, Sensory --- Analgesia and Anesthesia --- physiology --- PAIN --- PAIN MEASUREMENT --- PAIN, POSTOPERATIVE --- VETERINARY --- DRUG THERAPY
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Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.
Research & information: general --- Chemistry --- thiazole --- piperazine --- tail-clip --- hot-plate --- acetic acid-induced writhing test --- opioid --- prodynorphin --- epigenetics --- transcription --- human brain --- morphine dosing --- behavior --- locomotor activity --- tolerance --- µ-opioid receptor --- DAMGO --- SR-17018 --- buprenorphine --- nalbuphine --- kappa opioid receptor agonist --- pruritis --- scratching --- mice --- TAT-HIV --- cholestasis --- chloroquine --- deoxycholic acid --- analgesic --- δ opioid receptor --- G-protein-biased agonist --- opioid peptide --- rubiscolins --- µ-opioid analgesics --- angiotensin receptors --- chronic pain --- neuropathic pain --- delta opioid receptor --- inverse agonist --- irreversible antagonist --- non-competitive antagonist --- molecular pharmacology --- free fatty acid receptors --- lipids --- opioid receptor --- colitis --- chemotype --- high-throughput screen --- allosteric modulation --- beta-arrestin --- molecular dynamics --- opioid receptors --- β-amino acids --- peptide synthesis --- receptor binding studies --- functional assay --- nociceptin/orphanin FQ receptor --- NOP receptor --- ligands --- nociceptin --- N/OFQ --- analgesia --- GPCR --- HS-731 --- peripheral opioid agonist --- binding --- selectivity --- molecular docking --- molecular dynamics simulations --- n/a --- fluorescence cross-correlation spectroscopy (FCCS) --- G protein-coupled receptor (GPCR) --- serotonin
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