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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

thermodynamic modeling --- molecular dynamics simulation --- poorly soluble drugs --- amorphous solid dispersions --- dissolution enhancement --- crystallization tendency --- continuous processing --- stability --- milling --- granulation --- thermal analysis --- amorphous --- ball milling --- pharmaceutical glass --- dissolution --- rebamipide --- poloxamer --- classification --- polyelectrolytes --- amorphisation --- self-assembly --- dissolution rate --- miscibility --- bioavailability --- solubility --- evaporation --- mesoporous --- polyelectrolyte excipient matrix --- polymer --- bicaludamide --- phase diagram --- Weibull dissolution model --- spectroscopic techniques --- anticancer drugs --- manufacturing methods --- nucleation --- molecular complex --- nanoaggregates --- enrofloxacin --- accelerated stability test --- solubility enhancement --- amorphous solid dispersion --- tadalafil --- process development --- amorphous polymeric salt --- Wood’s apparatus --- hot melt extrusion --- solid dispersions --- intrinsic dissolution rate --- solid dispersion --- interaction --- crystallization --- spray drying --- characterization --- ciprofloxacin

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This book gathers several manuscripts dealing with powder metallurgy processing. Both powders production and their processing to reach a final product can be found. In particular, the extraction of Ta and Ti powders from their oxides by the action of Mg is studied. Moreover, the synthesis of ball-milled Mn-Bi powder for magnetic uses is also presented in the book. Regarding powders processing, sintering of Fe-Co-Cu powder mixtures for their use as diamond impregnated tools, electrical resistance sintering of mechanically alloyed amorphous Al-Ti powders, cold pressed Fe-Si-B alloys with magnetic uses, hot extruded functionally graded Al-based materials, space holder sintering of Ti for medical implants, sintering of hard Co-based material, and electrical resistance sintering of Fe-WC hardmetals can be found in this book.

History of engineering & technology --- electrical resistance sintering --- hardmetal --- ultrafine grain --- titanium powder --- self-propagating high-temperature synthesis --- acid leaching --- magnesium --- magnesium oxide --- tantalum powder --- magnesium reduction --- Ta2O5 powder --- MgO --- HCl solution --- functionally graded materials (FGMs) --- aluminum alloy --- hot extrusion --- Hall–Petch equation --- Kelly–Tyson equation --- amorphous powders --- amorphous magnetic powder cores --- soft magnetic properties --- permeability --- direct current (DC) bias performance --- Mn55Bi45 powders --- low-energy ball milling --- surfactant --- particle size --- coercivity --- microstructure --- magnetic properties --- cobalt-based alloy --- mechanical alloying --- hot pressed sintering --- bone implant --- porous titanium --- cellular adhesion --- bacteria colonization --- osseointegration --- amorphisation --- crystallisation --- Al-Ti powders --- porosity --- hardness --- pre-alloyed agglomerates --- mechanical properties --- cutting performance --- diamond impregnated tools --- stone machining --- tool wear --- n/a --- Hall-Petch equation --- Kelly-Tyson equation --- Engineering --- Technology --- History.