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The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.


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Information Theory in Molecular Evolution: From Models to Structures and Dynamics
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue collects novel contributions from scientists in the interdisciplinary field of biomolecular evolution. Works listed here use information theoretical concepts as a core but are tightly integrated with the study of molecular processes. Applications include the analysis of phylogenetic signals to elucidate biomolecular structure and function, the study and quantification of structural dynamics and allostery, as well as models of molecular interaction specificity inspired by evolutionary cues.

Keywords

Research & information: general --- Biology, life sciences --- power law --- Brownian process --- Kolmogorov complexity --- entropy --- chaos --- monofractal --- non-linear --- cumulative sum --- sequence analysis --- protein engineering --- direct coupling analysis --- evolutionary coupling analysis --- contact prediction --- phylogenetic bias --- phylogeny --- co-evolution --- coevolutionary analysis --- direct-coupling analysis --- specificity determining contacts --- sequence reweighting --- maximum entropy models --- protein contact predictions --- TEM-1 --- TOHO-1 --- PBP-A --- DD-transpeptidase --- conformational changes --- catalytic mechanism --- evolution --- epistasis --- allostery --- elastic network model --- protein conformational dynamics --- statistical inference --- mutational phenotypes --- interaction specificity --- phosphorylation --- fitness landscape --- bacterial signaling --- power law --- Brownian process --- Kolmogorov complexity --- entropy --- chaos --- monofractal --- non-linear --- cumulative sum --- sequence analysis --- protein engineering --- direct coupling analysis --- evolutionary coupling analysis --- contact prediction --- phylogenetic bias --- phylogeny --- co-evolution --- coevolutionary analysis --- direct-coupling analysis --- specificity determining contacts --- sequence reweighting --- maximum entropy models --- protein contact predictions --- TEM-1 --- TOHO-1 --- PBP-A --- DD-transpeptidase --- conformational changes --- catalytic mechanism --- evolution --- epistasis --- allostery --- elastic network model --- protein conformational dynamics --- statistical inference --- mutational phenotypes --- interaction specificity --- phosphorylation --- fitness landscape --- bacterial signaling


Book
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria
Authors: --- --- ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Bookmark

Abstract

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.

General microbiology
Authors: ---
ISBN: 052127270X 0521252776 9780521252775 9780521272704 Year: 1986 Publisher: Cambridge : Cambridge University Press,


Book
Information Theory in Molecular Evolution: From Models to Structures and Dynamics
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue collects novel contributions from scientists in the interdisciplinary field of biomolecular evolution. Works listed here use information theoretical concepts as a core but are tightly integrated with the study of molecular processes. Applications include the analysis of phylogenetic signals to elucidate biomolecular structure and function, the study and quantification of structural dynamics and allostery, as well as models of molecular interaction specificity inspired by evolutionary cues.


Book
Information Theory in Molecular Evolution: From Models to Structures and Dynamics
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue collects novel contributions from scientists in the interdisciplinary field of biomolecular evolution. Works listed here use information theoretical concepts as a core but are tightly integrated with the study of molecular processes. Applications include the analysis of phylogenetic signals to elucidate biomolecular structure and function, the study and quantification of structural dynamics and allostery, as well as models of molecular interaction specificity inspired by evolutionary cues.


Book
Matters of Life and Death : Perspectives on Public Health, Molecular Biology, Cancer, and the Prospects for the Human Race
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ISBN: 0691002509 Year: 1998 Publisher: Princeton, NJ : Princeton Univ. Press,

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Cancer has become the scourge of the twentieth century. It was always part of the human condition, but until recently it was not a common cause of death because most people died from the infectious diseases. Now that so many of us will live long enough to develop cancer, we need to learn as much about it as we can. This requires some understanding of molecular biology. John Cairns has made significant contributions to cancer research, molecular biology, and virology. He believes that it is possible to explain what is known about cancer and about molecular biology in terms that are easily understood by people with little or no scientific training. In this fascinating book, he explores the revolution in public health, the origins and principles of molecular biology, and our emerging understanding of the causes of cancer. Finally, he discusses how these developments are likely to affect future generations. As Cairns points out, the last two hundred years have altered our life expectations beyond all recognition. Even in the less developed nations of the world, people are starting to believe that everyone ought to be able to live into old age and be protected from the major causes of premature death. This change in our expectations is one of the major benefits of technology and the biological sciences. But the resulting explosion in the human population ultimately threatens everything we have gained by scientific progress.

The evolution of complexity : by means of natural selection
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ISBN: 0691084947 Year: 1988 Publisher: Princeton : Princeton University Press,

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John Tyler Bonner makes a new attack on an old problem: the question of how progressive increase in the size and complexity of animals and plants has occurred. "How is it," he inquires, "that an egg turns into an elaborate adult? How is it that a bacterium, given many millions of years, could have evolved into an elephant?" The author argues that we can understand this progression in terms of natural selection, but that in order to do so we must consider the role of development--or more precisely the role of life cycles--in evolutionary change. In a lively writing style that will be familiar to readers of his work The Evolution of Culture in Animals (Princeton, 1980), Bonner addresses a general audience interested in biology, as well as specialists in all areas of evolutionary biology. What is novel in the approach used here is the comparison of complexity inside the organism (especially cell differentiation) with the complexity outside (that is, within an ecological community). Matters of size at both these levels are closely related to complexity. The book shows how an understanding of the grand course of evolution can come from combining our knowledge of genetics, development, ecology, and even behavior.

Keywords

Biological Evolution. --- Models, Genetic. --- Population Dynamics. --- 575.8 --- Demographic Aging --- Demographic Transition --- Optimum Population --- Population Decrease --- Population Pressure --- Population Replacement --- Population Theory --- Residential Mobility --- Rural-Urban Migration --- Stable Population --- Stationary Population --- Malthusianism --- Neomalthusianism --- Aging, Demographic --- Decrease, Population --- Decreases, Population --- Demographic Transitions --- Dynamics, Population --- Migration, Rural-Urban --- Migrations, Rural-Urban --- Mobilities, Residential --- Mobility, Residential --- Optimum Populations --- Population Decreases --- Population Pressures --- Population Replacements --- Population Theories --- Population, Optimum --- Population, Stable --- Population, Stationary --- Populations, Optimum --- Populations, Stable --- Populations, Stationary --- Pressure, Population --- Pressures, Population --- Replacement, Population --- Replacements, Population --- Residential Mobilities --- Rural Urban Migration --- Rural-Urban Migrations --- Stable Populations --- Stationary Populations --- Theories, Population --- Theory, Population --- Transition, Demographic --- Transitions, Demographic --- Genetics, Population --- Genetic Models --- Genetic Model --- Model, Genetic --- Evolution, Biological --- Sociobiology --- Evolution. Origin of species. Phylogeny --- Evolution (Biology) --- Natural selection. --- Evolution --- Models --- Population dynamics --- genetic --- Life History Traits --- Evolution (Biology). --- Evolution. --- Population dynamics. --- genetic. --- 575.8 Evolution. Origin of species. Phylogeny --- Natural selection --- Biological Evolution --- Models, Genetic --- Population Dynamics --- Darwinism --- Selection, Natural --- Genetics --- Variation (Biology) --- Biological invasions --- Heredity --- Animal evolution --- Animals --- Biological evolution --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Biological fitness --- Homoplasy --- Phylogeny --- Genetic. --- razvojna biologija --- evolucija --- anatomija --- gostota naseljenosti --- razporeditev naseljenosti --- etologija. --- darwinizem --- fosili --- kompleksnost --- velikost telesa --- združbe --- populacije. --- Darwinian evolution. --- Dictyostelium. --- Hutchinson ratio. --- Kirschner, M. --- Lamarckism. --- aclonal organisms. --- acrasids. --- allostery. --- apical meristem. --- behavior. --- cambium. --- cell competition. --- conquest of land. --- convergent evolution. --- developmental constraints. --- dictyostelids. --- dominance hierarchy. --- earthworms. --- ecology. --- elastic similarity. --- endoskeleton. --- energid. --- food chains. --- gene net. --- genetic drift. --- habituation, in Stentor. --- heterochrony. --- heterocysts. --- inductors, in development. --- integrating mechanisms. --- isolating mechanisms. --- jellyfish. --- kelp. --- lichens. --- liverworts. --- macronucleus. --- mammals. --- metamorphosis. --- mosaic development. --- natural selection. --- nematocytes. --- neurotransmitter. --- notochord. --- pattern formation. --- pioneering. --- population biology. --- punctuated equilibria. --- regulative development. --- scavengers. --- siphonophores. --- species formation.

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