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"Analyzes the deliberations and impact of the South African Truth and Reconciliation Commission (TRC). Argues that while it failed to realize its idealistic goals, its very failure generated valuable contestation within and beyond the TRC process"--Provided by publisher.

Rhetoric --- Deliberative democracy --- Post-apartheid era --- Apartheid --- Reconciliation --- Social aspects --- South Africa. --- Rhetoric agonism truth reconciliation. --- deliberation. --- justice accountability speech silence.

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Leslie Thiele presents an original and accessible essay on the great thinker's attempt to lead a heroic life as a philosopher, artist, saint, educator, and solitary. He takes as his point of departure Nietzsche's conception of the soul as a multiplicity of conflicting drives and personae, and focuses on the task Nietzsche allotted himself "to make a cosmos out of his chaotic inheritance." This struggle to "become what you are" by way of a spiritual politics is demonstrated to be Nietzsche's foremost concern, which fused his philosophy with his life.

Nietzsche, Friedrich. --- Nietzsche, Friedrich Wilhelm, --- Nietzsche, Friedrich --- Achilles. --- Aeschylus. --- Apollonian. --- Aristotle. --- Asclepius. --- Beyond Good and Evil. --- Birth of Tragedy, The. --- Brombert, Victor. --- Calypso. --- Crito. --- Cyclops. --- Daedalus. --- Daybreak. --- Dionysian man. --- Dionysian. --- Dionysus. --- Ecce Homo. --- Eckermann. --- Epicurus. --- Euripides. --- German philosophy. --- Glaucon. --- Hamlet. --- Hector. --- Hecuba. --- Heraclitus. --- Homer. --- Medusa. --- Odysseus. --- Pascal. --- agonism, agonal. --- apotheosis. --- artist. --- asceticism. --- atheism. --- consciousness. --- decadence. --- democracy. --- determinism. --- dualism. --- education. --- egoism. --- eternal recurrence. --- fame. --- fatalism. --- heroic individualism. --- individual, as multiplicity. --- instincts. --- laughter. --- laws of nature. --- ontology. --- perspectivism. --- rationalism.

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The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

opioid receptors --- neurokinin-1 receptor --- peptide synthesis --- receptor binding studies --- functional assay --- writhing test --- tolerance --- Leu-enkephalin --- beta-arrestin --- mu opioid receptor --- delta opioid receptor --- biased signaling --- DADLE --- ischemia --- plasma stability --- morphinan --- BNTX --- δ opioid receptor antagonist --- 1H-NMR experiments --- mechanism elucidation --- peripheral antinociception --- 14-methoxycodeine-6-O-sulfate --- codeine-6-O-sulfate --- opioid peptides and peptidomimetics --- DAMGO --- DALDA --- [Dmt1]DALDA --- KGOP01 --- binding --- molecular docking --- structure-activity relationships --- β2-amino acids --- β2-Homo-amino acids --- µ-opioid receptor --- opioid peptides --- TAPP --- racemic synthesis of β2-amino acids --- peripheral µ-opioid receptors --- analgesia --- peripheral analgesic tolerance --- dysbiosis --- opioid --- bifunctional ligands --- (−)-N-phenethylnorhydromorphone analogs --- [35S]GTPgammaS assay --- forskolin-induced cAMP accumulation assays --- β-arrestin recruitment assays --- MOR and DOR agonists --- respiratory depression --- bias factor --- molecular modeling &amp --- simulation --- δ opioid receptor --- NTI derivative --- sulfonamide --- inverse agonist --- neutral antagonist --- agonist --- opioids --- mu receptor --- opioid side effects --- biased agonism --- partial agonism --- zerumbone --- chronic constriction injury (CCI) --- allodynia --- hyperalgesia --- potassium channels --- over-the-counter drugs --- misuse --- abuse --- opioid drugs --- pharmacology --- codeine --- dihydrocodeine --- loperamide --- opioid peptide --- macrocyclic tetrapeptide --- multifunctional ligands --- kappa opioid receptor --- analgesics --- opioid liabilities --- μ opioid receptor --- receptor model --- biased ligands --- dependence --- pain therapy --- neonatal opioid withdrawal syndrome --- naltrexone --- 6β-naltrexol --- buprenorphine --- G-protein bias --- arrestin recruitment --- respiration --- mitragynine --- heteromer --- internalization --- primary hippocampal culture --- lysosomes --- µ opioid receptor --- molecular dynamics --- docking --- interaction fingerprints --- biased agonists --- SR-17018 --- PZM21 --- morphine --- fentanyl --- diphenethylamines --- design and synthesis --- structure–activity relationships --- partial agonist --- biased agonist --- antagonist --- binding affinity --- selectivity --- n/a

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Modern information communication technology eradicates barriers of geographic distances, making the world globally interdependent, but this spatial globalization has not eliminated cultural fragmentation. The Two Cultures of C.P. Snow (that of science–technology and that of humanities) are drifting apart even faster than before, and they themselves crumble into increasingly specialized domains. Disintegrated knowledge has become subservient to the competition in technological and economic race leading in the direction chosen not by the reason, intellect, and shared value-based judgement, but rather by the whims of autocratic leaders or fashion controlled by marketers for the purposes of political or economic dominance. If we want to restore the authority of our best available knowledge and democratic values in guiding humanity, first we have to reintegrate scattered domains of human knowledge and values and offer an evolving and diverse vision of common reality unified by sound methodology. This collection of articles responds to the call from the journal Philosophies to build a new, networked world of knowledge with domain specialists from different disciplines interacting and connecting with other knowledge-and-values-producing and knowledge-and-values-consuming communities in an inclusive, extended, contemporary natural–philosophic manner. In this process of synthesis, scientific and philosophical investigations enrich each other—with sciences informing philosophies about the best current knowledge of the world, both natural and human-made—while philosophies scrutinize the ontological, epistemological, and methodological foundations of sciences, providing scientists with questions and conceptual analyses. This is all directed at extending and deepening our existing comprehension of the world, including ourselves, both as humans and as societies, and humankind.

pessimistic induction --- n/a --- qualitative ontology --- dissipative structures --- physicalism --- agent-based reasoning --- thermodynamics --- the logic of nature --- reverse mathematics --- theoretical unity --- state-space approach --- common good --- naturalization of logic --- monad --- metaphysics --- reflexive psychology --- knowledge --- neurodynamics --- consciousness --- third-way reasoning --- induction and discovery of laws --- mind-matter relations --- exoplanet --- Second Law of thermodynamics --- unitarity --- philosophical foundations --- in the name of nature --- big crunch --- epistemology --- eco-cognitive model --- active imagination --- aesthetics in science --- science --- second-person description --- subsumptive hierarchy --- 1st-person and 3rd-person perspectives --- discursive space --- space flight --- complexity --- cybernetics --- cosmology --- matter --- realism --- eco-cognitive openness --- hylomorphism --- measurement --- fallacies --- induction --- vacuum --- physics --- mental representation --- embodiment --- problem of induction --- contradiction --- internalism --- Jungian psychology --- synthesis --- exceptional experiences --- mind --- relational biology --- symmetry breaking --- emergence --- phenomenological psychology --- Aristotle’s four causes --- humanistic management --- real computing --- A.N. Whitehead --- final cause --- naturalism --- induction and concept formation --- temporality --- dispositions --- dark energy --- heterogeneity --- Naturphilosophie --- computation --- causality --- memory evolutive system --- natural philosophy --- quantum computing --- philosophy of information --- self --- information --- analytical psychology --- logic --- indeterminacy --- scientific method --- dialectics --- computability --- language --- ethics --- perception --- philosophy of nature --- agonism --- errors of reasoning --- everyday lifeworld --- emptiness --- awareness --- unity of knowledge --- digitization --- fitness --- depth psychology --- info-computational model --- creativity --- ontology --- philosophy as a way of life --- development --- void --- big freeze --- signal transduction --- abduction --- retrocausality --- dual-aspect monism --- quantum information --- theoretical biology --- acategoriality --- epistemic norms --- evolutionary psychology --- apophasis --- differentiation --- memory --- centripetality --- mathematics --- Leibniz --- Ivor Leclerc --- spatial representation --- subjective experience --- intentionality --- evidence and justification --- internal quantum state --- scientific progress --- holographic encoding --- information-theory --- qualia --- anticipation --- naturalization --- F.W.J. Schelling --- L. Smolin --- R.M. Unger --- Aristotle --- dual aspects --- process --- theory of everything --- philosophy of science --- cognition --- compositional hierarchy --- autocatalysis --- discourse --- emergentist reductionism --- form --- regulation --- contingency --- endogenous selection --- category theory --- Science --- Philosophy of nature. --- Philosophy. --- Nature --- Nature, Philosophy of --- Natural theology --- Normal science --- Philosophy of science --- Philosophy --- Aristotle's four causes