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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Biology, life sciences --- Mitochondria --- Aging --- age-related disease --- Lysosome --- Endoplasmic Reticulum

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This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners.

IGF-I --- IGF-II --- insulin --- IGF-IR --- IRs --- tyrosine kinase receptor --- GPCRs --- hybrids --- phosphorylation --- G-proteins --- β-arrestins --- functional RTK/GPCR hybrid --- nuclear translocation --- IGF-I receptor --- signaling --- targeted therapeutics --- IGF-Trap --- IGF system --- IGFBP-3 --- IGFBP-3R --- TMEM219 --- anti-tumor --- anti-metastatic --- agonists --- mAb therapy --- IGF-1 --- IGFBP-1 --- older adults --- longevity --- health-span --- age-related disease --- cognitive impairment --- diabetes --- mitochondria --- growth hormone --- insulin-like growth factor-1 --- aging --- oxidative stress --- senescence --- longitudinal study --- IGFBP --- mouse models --- skeletal muscle --- MSCs --- myogenesis --- glucose regulated protein (GRP) 94 --- insulin-like growth factor --- obligate chaperone --- hypertrophy --- atrophy --- cachexia --- muscle regeneration --- autophagy --- IGF-1R --- insulin receptor --- IR-A --- structural studies --- receptor activation --- n/a

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This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners.

Research & information: general --- Biology, life sciences --- IGF-I --- IGF-II --- insulin --- IGF-IR --- IRs --- tyrosine kinase receptor --- GPCRs --- hybrids --- phosphorylation --- G-proteins --- β-arrestins --- functional RTK/GPCR hybrid --- nuclear translocation --- IGF-I receptor --- signaling --- targeted therapeutics --- IGF-Trap --- IGF system --- IGFBP-3 --- IGFBP-3R --- TMEM219 --- anti-tumor --- anti-metastatic --- agonists --- mAb therapy --- IGF-1 --- IGFBP-1 --- older adults --- longevity --- health-span --- age-related disease --- cognitive impairment --- diabetes --- mitochondria --- growth hormone --- insulin-like growth factor-1 --- aging --- oxidative stress --- senescence --- longitudinal study --- IGFBP --- mouse models --- skeletal muscle --- MSCs --- myogenesis --- glucose regulated protein (GRP) 94 --- insulin-like growth factor --- obligate chaperone --- hypertrophy --- atrophy --- cachexia --- muscle regeneration --- autophagy --- IGF-1R --- insulin receptor --- IR-A --- structural studies --- receptor activation