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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

haploidentical transplantation --- T-cell depleted grafts --- T-cell-replete grafts --- post-transplantation cyclophosphamide --- immune reconstitution --- adoptive cell therapy --- regulatory T cells --- immune evasion

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Treating cancer has always been a major challenge. Although great strides in treatment have taken place in recent years, all too often current treatments are less than effective, or patients relapse. Newer methods of cancer treatment, namely targeted therapy and immunotherapy have generated great excitement in the scientific community. These newer methods of cancer treatment hold promise for patients who otherwise may have few options. Using the principles of health literacy, this updated edition includes many new therapies and describes the essential features of cancer treatments available to the general public in an engaging and stimulating manner. A simple, question/answer format and the use of illustrations, tables, charts, and boxes that highlight definitions, facts, and website links provide more detailed information.Features:Provides questions and answers about the characteristics of cancer, diagnosis, classifications, surgery, chemotherapy, radiation therapy, targeted therapy, adoptive cell therapy, new developments, and moreCites many new therapies and includes numerous in-text Web links to information at the National Institutes of Health, the National Cancer Institute, journals, and other online sourcesUses animations, practical tips, charts and tables, figures, and photos to explain topics under discussion.

Cancer --- Immunotherapy. --- Treatment. --- adoptive cell therapy. --- cancer. --- chemotherapy. --- hormone therapy. --- immune system. --- immunotherapy. --- radiation. --- surgery. --- targeted therapy. --- treatment. --- HEALTH & FITNESS / Diseases / Cancer.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- cellular therapy --- chimeric antigen receptor-T cell therapy --- chimeric antigen receptor-natural killer cell therapy --- adoptive cell therapy --- T cells --- natural killer cells --- immune effector cells --- cancer

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Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.

Medicine --- immunotoxin --- ribotoxin --- α-sarcin --- RNase T1 --- furin --- intracellular trafficking --- colorectal cancer --- botulinum toxin --- botulinum neurotoxin --- cancer --- cancer cells --- neuropathic pain --- post-surgical pain --- parotid gland --- submaxillary gland --- gustatory hyperhidrosis --- sialocele --- parotid fistula --- immunotherapy --- vaccine --- immune checkpoint inhibitors --- adoptive cell therapy --- cytokine therapy --- Coley’s Toxins --- glioblastoma --- drug discovery --- cytotoxic necrotizing factor type 1 --- protein purification --- recombinant protein production --- shiga toxins --- Gb3/CD77 --- apoptosis --- ER stress --- autophagy --- Burkitt lymphoma --- n/a --- Coley's Toxins

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Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.

Medicine --- immunotoxin --- ribotoxin --- α-sarcin --- RNase T1 --- furin --- intracellular trafficking --- colorectal cancer --- botulinum toxin --- botulinum neurotoxin --- cancer --- cancer cells --- neuropathic pain --- post-surgical pain --- parotid gland --- submaxillary gland --- gustatory hyperhidrosis --- sialocele --- parotid fistula --- immunotherapy --- vaccine --- immune checkpoint inhibitors --- adoptive cell therapy --- cytokine therapy --- Coley's Toxins --- glioblastoma --- drug discovery --- cytotoxic necrotizing factor type 1 --- protein purification --- recombinant protein production --- shiga toxins --- Gb3/CD77 --- apoptosis --- ER stress --- autophagy --- Burkitt lymphoma