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This book in the emerging research field of biomaterials covers biodegradable metals for biomedical applications. The book contains two main parts where each of them consists of three chapters. The first part introduces the readers to the field of metallic biomaterials, exposes the state of the art of biodegradable metals, and reveals its application for cardiovascular implants. Some fundamental aspects to give basic understanding on metals for further review on the degradable ones is covered in chapter one. The second chapter introduces the concept of biodegradable metals, it's state of the art and discuses a shifted paradigm from inert to bioactive, from corrosion resistant to corrodible metals. The third chapter focuses on the challenges and opportunities of using biodegradable metals for cardiovascular applications. The second part exposes an example of biodegradable metals from its concept to applications where a complete study on metallic biodegradable stent is detailed from materials design, development, testing till the implant fabrication. The forth chapter reveals new alloys development devoted for metallic biodegradable stent based on required criteria derived from clinical needs and current nondegradable stents properties. Degradation of the alloys in simulated arterial conditions and its effect to cells are exposed in chapter five. The both chapters are concluded with a benchmarking of some more recent researches on materials development and testing for biodegradable stents. Chapter six reveals the transformation process of the materials into stent prototypes where a standard process for making 316L stainless steel stents was followed. The book is completed by a perspective on the use of biodegradable metals for biomedical applications in the era of tissue engineering.

Biochemistry. --- Biomaterials. --- Biomedical engineering. --- Biomedical materials -- Biodegradation. --- Metals -- Biodegradation. --- Metals --- Biomedical materials --- Prostheses and Implants --- Myocardial Ischemia --- Biomedical and Dental Materials --- Investigative Techniques --- Inorganic Chemicals --- Vascular Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Specialty Uses of Chemicals --- Equipment and Supplies --- Heart Diseases --- Chemicals and Drugs --- Manufactured Materials --- Chemical Actions and Uses --- Technology, Industry, and Agriculture --- Cardiovascular Diseases --- Diseases --- Technology, Industry, Agriculture --- Coronary Disease --- Materials Testing --- Stents --- Biocompatible Materials --- Absorbable Implants --- Health & Biological Sciences --- Biology --- Microbiology & Immunology --- Biomedical Engineering --- Biodegradation --- Biodegradation. --- Materials science. --- Medical biochemistry. --- Metals. --- Materials Science. --- Biomedical Engineering. --- Medical Biochemistry. --- Metallic Materials. --- Materials. --- Biomedical Engineering and Bioengineering. --- Engineering --- Engineering materials --- Industrial materials --- Engineering design --- Manufacturing processes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Medicine --- Biocompatible materials --- Biomaterials --- Medical materials --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Composition --- Bioartificial materials --- Hemocompatible materials --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Metallic elements --- Chemical elements --- Ores --- Metallurgy --- Biomaterials (Biomedical materials)

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Absorbable metals have shown significant clinical potential for temporary implant applications, where the material is eventually replaced by healthy, functioning tissue. However, several challenges remain before these metals can be used in humans. Innovations and further improvements are required. This book collects scientific contributions dealing with the development of absorbable metals with improved and unique corrosion and mechanical properties for applications in highly loaded implants or cardiovascular and urethral stents.

surface treatments --- roughness --- Mg-alloys --- degradation behavior --- absorbable --- corrosion --- degradation --- magnesium --- ureteral stent --- zinc --- mandibular condylar fracture --- unsintered hydroxyapatite/poly-l-lactide composite plate --- bioactive resorbable plate --- biomechanical loading evaluation --- fracture fixation --- WE43/HA composite --- friction stir processing --- microstructure --- mechanical properties --- corrosion behavior --- absorbable metal --- cytotoxicity --- stent --- ureteral --- urothelial cells --- zinc alloy --- poly-L-lactide --- uncalcined and unsintered hydroxyapatite --- biocompatibility --- osteoconductivity --- mesenchymal stem cell --- iron foam --- polyethyleneimine (PEI) --- biodegradation --- powder metallurgy --- coating --- biodegradable magnesium implants --- bioceramics --- bioactivity --- orthopedic implant --- bone surgery --- absorbable implants --- magnesium (Mg) --- oral and maxillofacial --- orthopedic --- titanium (Ti) --- biomaterials --- electrochemistry --- hydrogen evolution --- microscopy --- Mg-Zn-Sn alloy --- osteoinductive activity --- sirolimus --- rabbit coronary artery endothelial cells --- smooth muscle cells --- bioabsorbable metals --- in-vivo biocompatibility --- strontium --- toxicity --- systemic reactions --- alloy accumulation --- internal organs --- iron --- corrosion rate --- biodegradable material --- n/a

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Active implants are drug or protein-eluting implants that induce healing effects, in addition to their regular task, for example support. This effect is achieved by controlled release of bioactive agents to the surrounding tissue. This book presents a broad overview of biomaterial platforms used in internal and external drug-eluting implants. The book is divided into four parts: 1. Drug-eluting implants 2. Scaffolds for bone regeneration 3. Scaffolds based on natural polymers 4. New polymeric systems for active implants The 18 reviews describe active implants in terms of matrix formats, incorporated drugs and their release profiles from the implants, as well as cell-implant interactions and functions. The effect of the process parameters on the micro or nano-structure and on the resulting drug release profiles, mechanical and physical properties, and other relevant properties, are emphasized.  It is the first book to describe a broad range of active implants and present the frontier of knowledge in this field. The new biomaterial approaches for active implants described in this book enhance the tools available for clinically important biomedical applications.

Tissue engineering. --- Biomedical and Dental Materials --- Culture Media --- Reconstructive Surgical Procedures --- Prostheses and Implants --- Culture Techniques --- Equipment and Supplies --- Clinical Laboratory Techniques --- Manufactured Materials --- Chemicals and Drugs --- Specialty Uses of Chemicals --- Surgical Procedures, Operative --- Technology, Industry, and Agriculture --- Investigative Techniques --- Chemical Actions and Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Technology, Industry, Agriculture --- Guided Tissue Regeneration --- Biocompatible Materials --- Absorbable Implants --- Tissue Scaffolds --- Tissue Engineering --- Surgery & Anesthesiology --- Health & Biological Sciences --- Biomedical Engineering --- Prosthesis & Artificial Organs --- Guided tissue regeneration --- Tissue scaffolds. --- Tissue-integrated prostheses. --- Equipment and supplies. --- Tissue-integrated implants --- Tissue-integrated prosthesis --- Scaffolding, Tissue --- Scaffolds, Tissue --- Tissue scaffolding --- Engineering. --- Molecular biology. --- Medicinal chemistry. --- Medical biochemistry. --- Biomedical engineering. --- Biomaterials. --- Biomedical Engineering. --- Molecular Medicine. --- Medical Biochemistry. --- Medicinal Chemistry. --- Prosthesis --- Osseointegration --- Tissue engineering --- Equipment and supplies --- Medicine. --- Biochemistry. --- Biomedical Engineering and Bioengineering. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Composition --- Health Workforce --- Bioartificial materials --- Hemocompatible materials --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology --- Biomaterials (Biomedical materials)