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In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om various viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.

Zinc-finger proteins. --- Zinc proteins. --- Metalloproteins --- Zinc fingers --- Zinc proteins --- Biochemistry. --- Cytology. --- Oncology. --- Protein Science. --- Cell Biology. --- Biochemistry, general. --- Cancer Research. --- Tumors --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition

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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Zinc-finger proteins. --- Zinc-finger proteins --- Gold compounds. --- Inhibitors. --- Auric compounds --- Aurous compounds --- Chemicals --- Zinc fingers --- Zinc proteins --- Chemistry, inorganic. --- Chemistry, Organic. --- RNA-ligand interactions. --- Mass spectrometry. --- Bioorganic chemistry. --- Immunology. --- Inorganic Chemistry. --- Organometallic Chemistry. --- Protein-Ligand Interactions. --- Mass Spectrometry. --- Bioorganic Chemistry. --- Immunobiology --- Life sciences --- Serology --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Organic chemistry --- Chemistry --- Inorganic chemistry --- Inorganic compounds --- Inorganic chemistry. --- Organometallic chemistry . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Chemistry, Organometallic --- Metallo-organic chemistry

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Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.

DNA-binding proteins. --- Genetic regulation. --- Genomics. --- Medical genetics. --- Transcription factors. --- Genomics --- DNA-binding proteins --- Transcription factors --- Gene regulatory networks --- Medical genetics --- Kruppel-Like Transcription Factors --- Gene Regulatory Networks --- Physiology --- Genetics --- Zinc Fingers --- Biology --- Amino Acid Motifs --- Biological Science Disciplines --- DNA-Binding Proteins --- Regulatory Sequences, Nucleic Acid --- Transcription Factors --- Base Sequence --- Proteins --- Protein Structure, Secondary --- Natural Science Disciplines --- Disciplines and Occupations --- Protein Conformation --- Genetic Structures --- Amino Acids, Peptides, and Proteins --- Genetic Phenomena --- Molecular Conformation --- Chemicals and Drugs --- Phenomena and Processes --- Molecular Structure --- Biochemical Phenomena --- Chemical Phenomena --- Cytology --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cells --- Cytology. --- Molecular biology. --- Growth. --- Molecular biochemistry --- Molecular biophysics --- Cell biology --- Cellular biology --- Cell growth --- Life sciences. --- Cancer research. --- Cell biology. --- Developmental biology. --- Animal genetics. --- Animal physiology. --- Life Sciences. --- Cell Biology. --- Animal Genetics and Genomics. --- Animal Physiology. --- Cancer Research. --- Developmental Biology. --- Molecular Medicine. --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cytologists --- Cell proliferation --- Oncology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Development (Biology) --- Growth --- Ontogeny --- Tumors --- Animal physiology --- Animals --- Anatomy --- Health Workforce --- Cancer research