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This academic thesis by Zaheer Ali investigates the mechanisms of angiogenesis, the growth of blood vessels from preexisting vasculature, using zebrafish models. The research focuses on both developmental and pathological angiogenesis, particularly in the context of age-related macular degeneration (AMD), corneal angiogenesis, melanoma, and ischemic diseases. Key findings include the identification of choroidal neovascularization mechanisms, the role of VEGF and NF-kB signaling pathways in angiogenesis, and the potential therapeutic applications of biocompatible polymers for drug delivery. The work aims to enhance understanding of angiogenic processes to inform the development of more effective treatments for various diseases. The intended audience includes medical researchers, clinicians, and students in the field of medical and health sciences.

Blood-vessels. --- Zebra danios as laboratory animals. --- Blood-vessels --- Zebra danios as laboratory animals

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The zebrafish (Danio rerio) is one of the best animal models to understand biological mechanisms and develop new methods for treating some human diseases. In this framework, the zebrafish is a versatile animal model organism for many research fields because of its many advantages, including rapid embriyonic development, easy maintenance and transparency of its embryos. Zebrafish in Biomedical Research describes the current understanding of zebrafish as a model organism in biomedical science. Written by experts in the field, this volume discusses the potential use of zebrafish in neurological diseases such as Alzheimer's and Parkinson's, in respiratory and kidney diseases, and in developing new drugs.

Zebra danio. --- Zebrafish --- Animals, Laboratory --- Disease Models, Animal --- Biomedical Research --- Biology --- Zebra danios as laboratory animals. --- Medical toxicology --- Research. --- Zebrafish. --- Animals, Laboratory. --- Disease Models, Animal. --- Biomedical Research.

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Animal embryology and growth --- Fishes --- Zebra danios as laboratory animals. --- Danio zébré (Animal de laboratoire) --- Modèles animaux dans la recherche --- Danio zébré (Animal de laboratoire) --- Modèles animaux dans la recherche --- Animal models in research

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The zebrafish (Danio rerio) is one of the best animal models to understand biological mechanisms and develop new methods for treating some human diseases. In this framework, the zebrafish is a versatile animal model organism for many research fields because of its many advantages, including rapid embriyonic development, easy maintenance and transparency of its embryos. Zebrafish in Biomedical Research describes the current understanding of zebrafish as a model organism in biomedical science. Written by experts in the field, this volume discusses the potential use of zebrafish in neurological diseases such as Alzheimer's and Parkinson's, in respiratory and kidney diseases, and in developing new drugs.

Zebra danio. --- Zebrafish --- Animals, Laboratory --- Disease Models, Animal --- Biomedical Research --- Experimental Medicine --- Investigational Medicine --- Investigative Medicine --- Research, Biomedical --- Research, Medical --- Medical Research --- Medicine, Experimental --- Medicine, Investigational --- Medicine, Investigative --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Models, Biological --- Laboratory Animals --- Animal, Laboratory --- Laboratory Animal --- B. rerio --- D. rerio --- Zebra Fish --- Zebra Fishes --- Zebra danio --- Zebrafishes --- Brachydanio rerio --- Danio rerio --- D. rerios --- Fishes, Zebra --- Zebra danios --- danio, Zebra --- Zebrafish Proteins --- Barilius rerio --- Brachydanio frankei --- Cyprinus chapalio --- Cyprinus rerio --- Danio frankei --- Danio lineatus --- Indian danio --- Indian zebra fish --- Leopard danio --- Nuria rerio --- Perilampus striatus --- Rerio --- Striped danio --- Zebra fish (Danio) --- Zebrafish (Zebra danio) --- Danio --- Biology --- Zebra danios as laboratory animals. --- Research. --- Medical toxicology --- Laboratory animals --- Biological research --- Biomedical research