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New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it p

Viruses --- Viral genetics. --- Evolution. --- Virus genetics --- Microbial genetics --- Viral evolution --- Evolution (Biology) --- Genetics

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This practical book is part of the new Artech House Methods in Bioengineering series - volumes designed to offer detailed guidance on authoritative methods for addressing specific bioengineering challenges. Written and edited by recognized experts in the field, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This volume focuses on the design of state-of-the art methods for investigating complex biological systems and the development of complex models to analyze the data. Professionals find how-to guidance on experimental approaches for investigating cellular behavior in health and disease.

Bacterial genetics. --- Cytology --- Viral genetics. --- Virus genetics --- Viruses --- Microbial genetics --- Bacteria --- Bacteriology --- Technique. --- Genetics

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578 <08> --- Viral genetics --- Virus genetics --- Viruses --- Microbial genetics --- Virology--Verzamelwerken. Reeksen --- Genetics --- DNA viruses. --- Viral genetics. --- 578 <08> Virology--Verzamelwerken. Reeksen

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While the study of viral evolution has developed rapidly, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book fills this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.

RNA viruses. --- Viruses --- Viral genetics. --- Virus diseases. --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Virus genetics --- Microbial genetics --- Viral evolution --- Evolution (Biology) --- Riboviruses --- Viruses, RNA --- Evolution. --- Genetics

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Coronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.

Coronaviruses. --- Viral genetics. --- Virus genetics --- Viruses --- Microbial genetics --- Common cold viruses --- Coronaviridae --- Nidoviruses --- Genetics --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Coronavirus --- Virus Replication. --- genetics. --- Replication, Virus --- Replications, Virus --- Virus Replications --- DNA Replication --- Viral Replication --- Replication, Viral --- Replications, Viral --- Viral Replications --- Viral Replication Compartments --- Microbiology