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"Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories."--Publisher's description.

RNA viruses. --- Host-virus relationships. --- RNA editing. --- Virus inhibitors --- Antiviral agents. --- Virology --- Virus à ARN --- Relations hôte-virus --- ARN --- Virus --- Antiviraux --- Virologie --- Research --- Edition --- Inhibiteurs --- Recherche --- RNA viruses --- Host-virus relationships --- RNA editing --- Antiviral agents --- Basic Sciences. Molecular Biology --- Basic Sciences. Genetics --- Genetic Engineering --- Molecular Genetics --- Genetic Engineering. --- Molecular Genetics. --- Virus à ARN --- Relations hôte-virus --- Virology - Research

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Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses.

RNA viruses. --- Natural immunity. --- Cellular signal transduction. --- Virus diseases --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Riboviruses --- Viruses, RNA --- Viruses --- Immunological aspects. --- RNA Viruses --- Immunity, Innate --- Signal Transduction --- Virus à ARN --- Immunité naturelle --- Transduction du signal cellulaire --- Maladies à virus --- immunology. --- Immunologie