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Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.  .

Immunogenetics. --- Molecular immunology. --- Organisms --- Gene Silencing --- Viral Proteins --- Proteins --- Epigenesis, Genetic --- Amino Acids, Peptides, and Proteins --- Gene Expression Regulation --- Genetic Processes --- Chemicals and Drugs --- Genetic Phenomena --- Phenomena and Processes --- Viral Regulatory and Accessory Proteins --- Viruses --- RNA Interference --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immunity. --- Medicine. --- Immunology. --- Molecular biology. --- Virology. --- Microbial genetics. --- Microbial genomics. --- Plant pathology. --- Invertebrates. --- Biomedicine. --- Microbial Genetics and Genomics. --- Molecular Medicine. --- Plant Pathology. --- Invertebrata --- Animals --- Botany --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Plants --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Genomics --- Microbial genetics --- Microorganisms --- Genetics --- Microbiology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Diseases and pests --- Diseases --- Wounds and injuries --- Immunology --- Medical virology. --- Plant diseases. --- Medical microbiology --- Virology --- Virus diseases --- Health Workforce --- Medicine --- Microbial Genetics. --- Biomedical Research. --- Experimental Organisms. --- Research. --- Technique. --- Biological research --- Biomedical research