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Cells --- Transport Vesicles. --- Cell mechanics --- Cellular mechanics --- Biomechanics --- Endocytic Vesicles --- Endocytic Vesicle --- Transport Vesicle --- Vesicle, Endocytic --- Vesicle, Transport --- Vesicles, Endocytic --- Vesicles, Transport --- Vesicular Transport Proteins --- Mechanical properties. --- Histology. Cytology --- immunology --- neurobiology --- stem cells --- signal transduction --- membrane trafficking
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Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
Cellular signal transduction. --- Membrane proteins. --- Biochemical Processes --- Coated Pits, Cell-Membrane --- Vesicular Transport Proteins --- Cell Physiological Processes --- Biological Science Disciplines --- Coated Vesicles --- Membrane Microdomains --- Medicine --- Cell Physiological Phenomena --- Health Occupations --- Cell Membrane Structures --- Transport Vesicles --- Natural Science Disciplines --- Biochemical Phenomena --- Chemical Processes --- Membrane Proteins --- Disciplines and Occupations --- Chemical Phenomena --- Cell Membrane --- Cytoplasmic Vesicles --- Phenomena and Processes --- Proteins --- Amino Acids, Peptides, and Proteins --- Organelles --- Cellular Structures --- Cells --- Chemicals and Drugs --- Cytoplasmic Structures --- Anatomy --- Cytoplasm --- Intracellular Space --- Caveolins --- Caveolae --- Pathology --- Signal Transduction --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Biomedicine, general. --- Health Workforce
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For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning “little caves” in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interesting new perspectives on future advancement and therapeutic possibilities involving caveolins in cancer. This work brings together highly respected and experienced scientists in the field of caveolins who wrote informative chapters on the role of caveolin-1 in cancer in a format that conveys its role as both a tumor suppressor and tumor promoter. We invite you to read, enjoy and be part of these new promising discoveries that are rapidly advancing the field of cancer research.
Carcinogenesis. --- Carcinogenesis --- Adaptor Proteins, Signal Transducing --- Diseases --- Phosphoproteins --- Biological Markers --- Coated Pits, Cell-Membrane --- Membrane Microdomains --- Metabolic Phenomena --- Biological Science Disciplines --- Caveolins --- Biochemical Processes --- Medicine --- Coated Vesicles --- Cell Physiological Processes --- Health Occupations --- Intracellular Signaling Peptides and Proteins --- Carrier Proteins --- Phenomena and Processes --- Transport Vesicles --- Chemical Processes --- Biological Factors --- Cell Membrane Structures --- Vesicular Transport Proteins --- Cell Physiological Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Proteins --- Chemical Phenomena --- Amino Acids, Peptides, and Proteins --- Disciplines and Occupations --- Chemicals and Drugs --- Cytoplasmic Vesicles --- Cell Membrane --- Membrane Proteins --- Peptides --- Cellular Structures --- Organelles --- Cells --- Cytoplasmic Structures --- Anatomy --- Cytoplasm --- Intracellular Space --- Caveolin 1 --- Caveolae --- Metabolism --- Physiology --- Signal Transduction --- Neoplasms --- Tumor Markers, Biological --- Pathology --- Health & Biological Sciences --- Oncology --- Cancer --- Prevention. --- Treatment. --- Cancer therapy --- Cancer treatment --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Therapy --- Pathogenesis --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Genetic toxicology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect
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Comprehensively covers protein subcellular localization from single-label prediction to multi-label prediction, and includes prediction strategies for virus, plant, and eukaryote species. Three machine learning tools are introduced to improve classification refinement, feature extraction, and dimensionality reduction.
Artificial intelligence. --- Probability. --- Protein transport. --- Statistics as Topic --- Computing Methodologies --- Biological Transport --- Mathematical Concepts --- Phenomena and Processes --- Health Care Evaluation Mechanisms --- Information Science --- Epidemiologic Methods --- Metabolism --- Public Health --- Investigative Techniques --- Metabolic Phenomena --- Quality of Health Care --- Health Care Quality, Access, and Evaluation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Environment and Public Health --- Health Care --- Probability --- Protein Transport --- Artificial Intelligence --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Computational Intelligence --- AI (Artificial Intelligence) --- Computer Reasoning --- Computer Vision Systems --- Knowledge Acquisition (Computer) --- Knowledge Representation (Computer) --- Machine Intelligence --- Acquisition, Knowledge (Computer) --- Computer Vision System --- Intelligence, Artificial --- Intelligence, Computational --- Intelligence, Machine --- Knowledge Representations (Computer) --- Reasoning, Computer --- Representation, Knowledge (Computer) --- System, Computer Vision --- Systems, Computer Vision --- Vision System, Computer --- Vision Systems, Computer --- Heuristics --- Protein Localization Processes, Cellular --- Protein Sorting --- Protein Trafficking --- Cellular Protein Targeting --- Gated Protein Transport --- Protein Targeting, Cellular --- Protein Translocation --- Transmembrane Protein Transport --- Vesicular Protein Transport --- Protein Transport, Gated --- Protein Transport, Transmembrane --- Protein Transport, Vesicular --- Traffickings, Protein --- Protein Sorting Signals --- Vesicular Transport Proteins --- Probabilities --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Healthcare Quality, Access, and Evaluation --- Pharmacy Audit --- Quality of Care --- Quality of Healthcare --- Audit, Pharmacy --- Care Quality --- Health Care Quality --- Healthcare Quality --- Pharmacy Audits --- Metabolic Phenomenon --- Metabolic Process --- Metabolism Concepts --- Metabolism Phenomena --- Process, Metabolic --- Processes, Metabolic --- Anabolism --- Catabolism --- Metabolic Concepts --- Metabolic Processes --- Concept, Metabolic --- Concept, Metabolism --- Concepts, Metabolic --- Concepts, Metabolism --- Metabolic Concept --- Metabolism Concept --- Phenomena, Metabolic --- Phenomena, Metabolism --- Phenomenon, Metabolic --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Preventive Medicine --- Education, Public Health Professional --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- Information Sciences --- Science, Information --- Sciences, Information --- Healthcare Evaluation Mechanisms --- Evaluation Mechanism, Healthcare --- Evaluation Mechanisms, Healthcare --- Healthcare Evaluation Mechanism --- Mechanism, Healthcare Evaluation --- Mechanisms, Healthcare Evaluation --- Concept, Mathematical --- Concepts, Mathematical --- Mathematical Concept --- Biologic Transport --- Transport, Biological --- Transport, Biologic --- Transport Vesicles --- Membrane Transport Proteins --- High Performance Computing --- Methodologies, Computing --- Computing Methodology --- Computing, High Performance --- Methodology, Computing --- Performance Computing, High --- Area Analysis --- Estimation Technics --- Estimation Techniques --- Indirect Estimation Technics --- Indirect Estimation Techniques --- Multiple Classification Analysis --- Service Statistics --- Statistical Study --- Statistics, Service --- Tables and Charts as Topic --- Analyses, Area --- Analyses, Multiple Classification --- Area Analyses --- Classification Analyses, Multiple --- Classification Analysis, Multiple --- Estimation Technic, Indirect --- Estimation Technics, Indirect --- Estimation Technique --- Estimation Technique, Indirect --- Estimation Techniques, Indirect --- Indirect Estimation Technic --- Indirect Estimation Technique --- Multiple Classification Analyses --- Statistical Studies --- Studies, Statistical --- Study, Statistical --- Technic, Indirect Estimation --- Technics, Estimation --- Technics, Indirect Estimation --- Technique, Estimation --- Technique, Indirect Estimation --- Techniques, Estimation --- Techniques, Indirect Estimation --- methods --- Proteins --- Machine learning. --- Physiological transport --- Data processing. --- Learning, Machine --- Artificial intelligence --- Machine theory --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Bioinformatics. --- Computer Science. --- Proteomics.
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