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Escherichia coli --- Verocytotoxins --- Conferences - Meetings

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Shiga toxin-producing Escherichia coli (STEC) and its isolated cytotoxin (Stx), also known as "hamburger E. coli" are continuing sources of significant-and sometime fatal-human and animal infections. In E. coli: Shiga Toxin Methods and Protocols, a multidisciplinary panel of leading experimentalists details the key protocols for the diagnosis and study of STEC and Stx pathogenesis. Described in step-by-step detail, these readily reproducible techniques range from those for the diagnosis and detection of STEC bacteria in patient and animal samples, to those for studying the cellular microbiology of STEC infections, especially host-pathogen interactions and the hemolysin of STEC. There are also protocols for studying the details of Shiga toxin (Stx) biology-from the purification of the toxin to the effects of Stx on various host cell functions-and for exploring STEC-mediated disease in various animal models. Each protocol has been thoroughly tested and optimized to produce robust and successful experimental results, and includes troubleshooting tips, advice on avoiding pitfalls, and alternate methods. Comprehensive and up-to-date, E. coli: Shiga Toxin Methods and Protocols offers bacteriologists and medical microbiologists today's most powerful tools for illuminating the molecular and cellular microbiology of STEC's bacterial pathogenesis, as well as the mechanisms of its toxicity.

Escherichia coli infections --- Verocytotoxins --- Escherichia coli Infections --- Shiga Toxin --- pathology --- analysis --- Shiga-like toxins --- SLT (Bacterial toxin) --- VT (Bacterial toxin) --- Colibacillosis --- Enterotoxins --- Gram-negative bacterial infections --- Microbiology. --- Microbial biology --- Biology --- Microorganisms

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The intent of this volume of Current Topics in Microbiology and Immunology was to bring together a collection of in-depth and cutting edge reviews that highlight our current understanding of the biology of ricin and Shiga toxin (Stx), with the long term goal of advancing the development of countermeasures against these toxic agents.  In May of 2011, Western Europe experienced a severe outbreak of Stx-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths.  While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS).  At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection.  Nor are there any preventatives or therapeutics for ricin toxin.  Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat.  It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. As the title of this volume indicates, the chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.   .

Antigens and antibodies. --- Chemical agents (Munitions) -- Toxicology. --- Ricin. --- Toxins. --- Verocytotoxins. --- Ricin --- Verocytotoxins --- Chemical agents (Munitions) --- Immunoglobulins --- Ribosome Inactivating Proteins, Type 2 --- Enterotoxins --- Plant Lectins --- Bacterial Toxins --- Albumins --- Ribosome Inactivating Proteins --- Proteins --- Toxins, Biological --- Lectins --- Biological Factors --- N-Glycosyl Hydrolases --- Amino Acids, Peptides, and Proteins --- Plant Proteins --- Glycoside Hydrolases --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Shiga Toxins --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Pharmacy, Therapeutics, & Pharmacology --- Toxicology --- Immunotherapy. --- Vaccines. --- Therapeutic immunology --- Natural toxicants --- Toxicants, Natural --- Toxins and antitoxins --- Castor bean lectin --- Ricinus lectin --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Biologicals --- Clinical immunology --- Therapeutics --- Antigens --- Metabolites --- Poisons --- Antitoxins --- Detoxification (Health) --- Plant lectins --- Plant toxins --- Toxalbumins --- Toxicology. --- Medicine --- Pharmacology --- Poisoning